Sichuan University

ESG Gains Without Financial Returns? Assessing the Impact of Circular Economy Business Models

ABSTRACT This study examines the effects of circular economy business model adoption on ESG (environmental, social, and governance) and financial performance using panel data from 646 listed Chinese manufacturing firms (2016–2022). The results show that circular supply and resour...

Multiphase Flow Simulation in Hydrocarbon Reservoir: Balancing Computational Efficiency and Prediction Accuracy

ABSTRACT High‑fidelity reservoir simulations remain indispensable for predicting multiphase flow in porous media, yet their computational cost impedes real‑time decision‑making. Recent advances have demonstrated that deep‑learning proxies—such as convolutional and recurrent neura...

Maternal gestational diabetes mellitus and mental disorders, neurodevelopmental disorders, and neurodevelopmental scale outcomes in offspring: a systematic review and meta-analysis

The association between maternal gestational diabetes mellitus (GDM) and neuropsychiatric outcomes in offspring has not been fully systematically synthesized. We aimed to evaluate the association between maternal GDM and neuropsychiatric outcomes in offspring, including mental di...

Impact of inoculation of inactivated COVID-19 vaccine on the outcomes of frozen-thawed embryo transfer

Abstract To assess the impact of inoculation of inactivated corona virus disease 2019 (COVID-19) vaccine on the outcome of frozen-thawed embryo transfer (FET). From January 2022 to November 2023, patients aged 20 ~ 45 years old undergoing FET at the Reproductive Medicine Center o...

Cholesterol sulfate as a novel theranostic target for sepsis-induced liver injury through Beclin1-mediated autophagy enhancement and pyroptosis suppression

Sepsis remains a life-threatening syndrome, and septic liver injury is a frequent and critical complication for which no specific pharmacological therapy exists. Current biomarkers lack sufficient specificity for early diagnosis and severity assessment, highlighting an urgent nee...

Between embodiment and imagination: Developing perceived therapeutic attributes of rural tourism

This study advances embodied cognition theory by introducing a dual-pathway model, where healing experiences in rural settings arise from the interplay of mirror simulation and mental imagery. Perceived therapeutic attributes of rural tourism are defined as those interactive qual...

Machine learning identifies plasma-derived exosomal miRNAs associated with low muscle mass in Tibetan patients with rheumatoid arthritis

Sarcopenia poses a significant health burden in aging populations, particularly among patients with rheumatoid arthritis (RA), but current diagnostic approaches face limitations in early detection. This study aims to identify plasma-derived exosomal miRNA features associated with...

Extensive melorheostosis of the upper extremity: Evaluation of disease activity with 99mTc-MDP bone scintigraphy.

Tc-MDP) bone scintigraphy demonstrated intense tracer uptake, indicating high metabolic activity despite the long-term disease course. Three-dimensional computed tomography (CT) reconstruction visualized extensive hyperostosis crossing multiple joints, while magnetic resonance im...

18F-FDG PET/CT of primary malignant melanoma arising from the Eustachian tube region.

F-FDG uptake with a maximum standardized uptake value (SUVmax) of 10.59. Postoperative pathology confirmed malignant melanoma of the right torus tubarius.

Climate extremes are associated with crime dynamics in China

While the societal implications of climate extremes have received considerable attention, the specific associations with crime dynamics remain unclear. Leveraging a unique nationwide crime panel dataset (over 8.6 million) parsed via large-scale textual analysis, we capture detail...

Development and validation of a nursing-oriented triage decision tool for prehospital trauma patients in China: a retrospective cohort study

In China, prehospital emergency medical services (EMS) frequently employ nurses as frontline triage personnel, a practice that differs from EMS systems in many Western countries where paramedics typically fulfill this role. However, existing triage tools such as ATLS and CRAMS we...

Comparative efficacy and safety of neoadjuvant and perioperative systemic therapies for resectable locally advanced gastric and gastroesophageal junction adenocarcinoma: a network meta analysis of randomized controlled trials

The optimal neoadjuvant or perioperative systemic strategy for resectable locally advanced gastric cancer (LAGC) and gastroesophageal junction adenocarcinoma (GEJA) remains uncertain. This study compared clinically defined treatment classes rather than individual regimens. PubMed...

Metabolic engineering and deep learning-driven protein engineering for N-Acetylneuraminic acid biosynthesis in Escherichia coli

N-Acetylneuraminic acid (NeuAc) is a sialic acid valued in pharmaceuticals and infant nutrition, and microbial synthesis offers a scalable route once the pathway’s catalytic bottlenecks are relieved. We combine deep learning with metabolic engineering to build a high-titer NeuAc-...

The Efficacy of Adjuvant EGFR-TKI Therapy for Stage IA Lung Adenocarcinoma with EGFR Mutations: A Retrospective Cohort Study

Abstract Introduction Surgical resection is the standard for early-stage lung adenocarcinoma (LUAD), but recurrence remains a risk for patients with epidermal growth factor receptor (EGFR) mutations. The efficacy of adjuvant EGFR tyrosine kinase inhibitors (EGFR-TKIs) in stage IA...

Tertiary lymphoid structures in cancer: their development, composition, clinical prognosis, and the drivers of the anti-tumor responses

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates formed under chronic inflammatory tumor microenvironments. Clinical cohorts across solid cancers demonstrate that mature TLS with intact germinal centers serve as independent favorable prognostic biomarkers and pr...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Comparative efficacy of various wound dressings on scar formation following thyroidectomy: a systematic review and meta-analysis

Background: Visible cervical scarring remains a common concern following conventional thyroidectomy and may adversely affect cosmetic satisfaction and quality of life. Although several postoperative wound interventions have been introduced to improve scar healing, their comparati...

Imidazole-Mediated Size-Tunable ZIF(Cu) Particles Enhance the CO2 Separation Performance of Pebax-Based MMMs

Abstract The particle size of ZIFs has a significant effect on the CO2 separation performance of mixed matrix membranes (MMMs). Herein, an imidazole-mediated protonation strategy was developed to regulate the particle size of ZIF(Cu), achieving tunable sizes spanning more than on...

Controllable Reconstruction of the Ni/MgAl2O4 Catalyst by In Situ Liquid-Phase Reduction Combined with an Adsorption-Impregnation Strategy to Enhance Reaction Performance for MCH Steam Reforming

Abstract Hydrogen production via catalytic steam reforming of high-carbon hydrocarbons, with low cost, strong adaptability, and easy industrialization, is one of the core technologies for addressing the hydrogen supply bottleneck of fuel cells. However, traditional synthesis meth...

Absolute and Amplified Virus Detection by Isotope Dilution after Catalytic Hairpin Assembly

Abstract The detection of viruses is of great significance for the diagnosis of related diseases. However, current virus detection often faces two challenges: first, due to the complex matrix of physiological samples, detection methods often fail to provide accurate quantitative...