Sichuan University

Enzyme-mimicking peripheral substituents beyond the second coordination sphere tune single-atom catalysts for periodate activation

Abstract Single-atom catalysts (SACs) are promising enzyme-mimetic active centers, yet mimicking long-range regulation by distal binding pockets in natural metalloenzymes remains challenging. Here, we synthesize conjugated organic SACs bearing tunable peripheral substituents beyo...

Collagen Fibers-Derived Superhydrophobic Foams for High-Performance Separation of Stable Emulsions

Abstract Superwetting separation has emerged as a promising alternative to address the environmental problems associated with emulsion wastewater. However, a major challenge for superwetting separation materials is the formation of a rejected phase that inevitably leads to foulin...

Precision Medicine for Somatic Mutation-Driven Vascular Anomalies

Vascular anomalies, including proliferative vascular tumours and structural malformations, are largely driven by postzygotic somatic mutations that constitutively activate key signalling pathways, mainly the PI3K/AKT/mTOR and RAS/MAPK pathways. This molecular understanding has sh...

Dynamic coordination engineering of gallium biomaterials: A biological accessibility framework for therapeutic biofunction

Gallium (Ga)-based biomaterials have emerged as versatile therapeutic platforms owing to the iron-mimicking properties and broad biological activities of gallium. Coordination engineering regulates Ga speciation, stability, transport, and therapeutic activation; however, optimizi...

miR-892b targeting CTNNB1 regulates sepsis-induced myocardial dysfunction

Numerous sepsis patients experience myocardial damage, leading to a high mortality rate of sepsis. To investigate the clinical and functional role of miR-892b in sepsis-induced myocardial dysfunction (SMD). The expression of miR-892b and CTNNB1 in clinical subjects was measured b...

From Reproductive Biology to Woody Oil Utilization: An Integrated Review and Bibliometric Analysis of Idesia polycarpa

Idesia polycarpa Maxim. is a predominantly dioecious woody oil species valued for its oil-bearing fruits, bioactive metabolites, and distinctive reproductive biology. To provide an integrated understanding of its biological characteristics, resource utilization, and research evol...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Breaking Barriers Toward Practicality: Critical Materials and Strategies for High‐Energy‐Density Aqueous Zinc‐Ion Batteries

ABSTRACT Driven by the demands of grid‐scale energy storage and the electrification of transport, achieving superior energy density is pivotal to establishing a more sustainable and economically resilient battery ecosystem. However, aqueous zinc‐ion batteries (ZIBs), despite thei...

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

ABSTRACT Sepsis‐induced pediatric acute lung injury (ALI) and pediatric acute respiratory distress syndrome (PARDS) are life‐threatening conditions with high mortality rates and no current cure. Most ALI/ARDS studies focus on adults, albeit the pediatric population has unique cha...

IRA-YOLO: Inter-Class Relation Attention for PPE Detection in Industrial Scenes

Personal protective equipment (PPE) detection in industrial scenes is a joint classification-and-localization problem complicated by partial occlusion, scale variation, and background clutter. PPE categories also follow structured physical relations; for example, helmets are norm...

A Data-Driven Framework for Characterizing Nonlinear Responses of River Ice Growth and Decay in the Shisifenzi Reach of the Upper Yellow River

The Shisifenzi Reach, with its sharp curvature, serves as a prime observational target for river ice research in the Upper Yellow River. Using six winter seasons (2020–2026) of monitoring data, this study developed a Random Forest with SHAP and Accumulated Local Effects (ALE) to...

Head-up lateral positioning during emergence from anaesthesia after ambulatory adenotonsillectomy in children: protocol for a multicentre randomised controlled trial

Tonsillectomy and adenoidectomy are common paediatric surgeries, with > 50% of children experiencing postoperative respiratory adverse events (PRAEs). Existing mitigation strategies have limitations, and evidence on positional interventions (e.g. lateral/semi-reclined) specifical...

Fine-Scale Assessment of Inequalities in Emergency Shelter Accessibility Using the 3SFCA Method: A Focus on Distributional Balance and Lower-Tail Welfare

With climate change and urbanization accelerating, cities face increasing disaster risks. As critical facilities for safeguarding residents’ safety, emergency shelters have attracted growing attention due to spatial supply–demand mismatches. From the perspective of the 15-min com...

GSCA-UNet: a gated spatial-channel attention U-net for accurate skin lesion segmentation

Abstract Medical image segmentation is a fundamental component of computer-aided diagnosis, where automatic skin lesion segmentation serves as a critical upstream task by providing pixel-wise delineations for subsequent analysis. Deep encoder-decoder architectures, such as U-Net...

Dynamic association between gut microbiota succession and host metabolism: differential effects of antibiotic intervention duration on glucose and lipid metabolism in high-fat diet-induced obese mice

Abstract Background The gut microbiota plays a critical role in the onset and progression of obesity. Previous studies have indicated that antibiotic administration may influence host physiology and pathology by modulating the gut microbiota. However, whether different durations...

Development and performance of filler-free buckling-restrained shape memory alloy devices for self-centering seismic applications

This study proposes a novel filler-free buckling-restrained SMA device for self-centering seismic applications. The proposed device consists of an SMA core bar, a confining tube, two swaged sleeves, two restraining sleeves, and two connection parts. The SMA bar includes a fuse pa...

Preoperative platelet-to-lymphocyte ratio and post-hepatectomy hemorrhage risk after elective hepatectomy: a single-center cohort study with exploratory calendar-time assessment of a candidate cutoff

Post-hepatectomy hemorrhage (PHH) is clinically important after liver resection, yet simple preoperative bleeding risk markers remain limited. We assessed whether preoperative platelet-to-lymphocyte ratio (PLR) was associated with PHH and derived an ROC-based threshold. In this a...

Clinical outcomes of bivalirudin and heparin in pediatric extracorporeal membrane oxygenation: A systematic review and meta-analysis

Managing anticoagulation during pediatric extracorporeal membrane oxygenation (ECMO) remains a persistent clinical challenge due to the narrow margin between life-threatening hemorrhage and thrombotic occlusion. While bivalirudin has gained traction as a promising alternative to...

Intraoral dental caries detection based on mask-regularized vision transformer

Accurate detection of dental caries supports early intervention; however, many deep-learning approaches require dense pixel-level annotations for every image, which are costly to obtain and limit scalability. Models trained with limited supervision may also rely on spurious visua...

Mutual Optimization of Label Prediction and Node Representations for Multi-Label Node Classification

Multi-label node classification requires capturing complex label-co-occurrence patterns, which are critical for accurate predictions. However, traditional methods often treat label prediction as an independent task, overlooking the semantic relationships and dependencies between...