Karolinska Institutet

How are biomechanical and psychosocial factors associated with injuries across one season in Swedish elite and sub-elite female soccer players?

Abstract Background Soccer is a high-intensity contact sport, and the patterns and burden of injuries can vary based on age, sex, and player level. To better understand injury occurrence, it is important to identify biopsychosocial factors that are associated with injuries. Our s...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated cal...

Documentation-related diagnostic safety concerns in primary care: a structured medical record review of 1116 patient records

Background Diagnostic safety concerns are among the most consequential yet least visible threats to patient safety in primary care. Non-specific symptoms potentially associated with cancer represent a high-risk context, where delayed diagnosis may have serious consequences despit...

Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the death of motor neurons leading to paralysis and death generally 3–5 years post-symptom onset. ALS is a cell- and non-cell-autonomous disease, with glia such as astrocytes influencing disease p...

Research Staff's Experiences of Applying the UNCRC in Clinical Research Involving Young Children—An Ongoing Process of Ethical Judgement

AIM: An estimated five million children under the age of five die each year, largely from preventable causes. Clinical research involving young children is essential for improving child health, but is ethically complex. The United Nations Convention on the Rights of the Child (UN...

Whole-blood transcriptomics identifies a distinct metabolic and inflammatory signature in lupus arthritis compared with rheumatoid arthritis

BACKGROUND: Lupus arthritis (LA) is a major determinant of clinical outcomes and treat-to-target strategies in systemic lupus erythematosus (SLE), yet its molecular basis remains elusive. METHODS: Whole-blood RNA sequencing from 170 SLE [67 with active arthritis but quiescent dis...

Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins

Abstract Both host genetics and environmental exposures shape the salivary microbiota; however, the relative contributions of these factors from early life to adulthood remain unclear. To address this, we profiled the salivary microbiota of 3387 twin pairs: 939 infant pairs (9–12...

Evidence-Based Insights for the Development and Talent Promotion of Young Athletes in a National Sports Context

Abstract The development of young athletes continues to be a key concern for sports organizations, coaches and policy makers. In Sweden, the public debate on the balance between early talent promotion programs and more inclusive, long-term athlete development models has recently...

Longitudinal plasma neurofilament light chain and patient-reported outcomes as complementary markers of vincristine-associated peripheral neuropathy in adults with lymphoma: a cohort study

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxicity of cancer treatment with limited diagnostic, monitoring, and treatment options. Neurofilament light chain (NfL) is an axonal cytoskeletal protein released during neuroaxonal injury and a promisin...

Effects of heat exposure on self-reported heat strain symptoms among pregnant and postpartum women in South Africa

Abstract Heat exposure can harm pregnant and postpartum women, yet heat strain symptoms in this population remain underexplored. This study implemented a novel mobile application and assessed the environmental context of five self-reported heat strain symptoms: skin rashes, sleep...

Bimekizumab as an Effective Treatment in Darier Disease: Clinical Outcomes of a Single-Center Retrospective Analysis of Patients Treated with Biologics

Darier disease (DD) is a rare autosomal dominant genodermatosis with limited systemic therapeutic options. Retinoids are the gold standard therapy, but long-term application is frequently limited by adverse events. Case reports suggest that biologicals approved for psoriasis vulg...

Contraceptive and condom use among women from key populations in Myanmar

Abstract Background Contraceptive and condom use remain low among women in marginalized communities, including those who sell sex, use or inject drugs, or are sexual partners of people who use or inject drugs (key populations). This study examines how selling sex and drug use rel...

Trends in early-onset cancer incidence rates in the Nordic countries (2003–2022): a population-based study

Background Increasing incidence rates of early-onset cancer at ages 20–49 years have been reported in several countries, especially for colorectal, kidney and breast cancer. We examined recent incidence trends of early-onset cancer in Denmark, Finland, Iceland, Norway, Sweden, Gr...

Diagnosis of urinary tract infection in the emergency department – a real infection or an alarming indication for comprehensive geriatric assessment? A retrospective follow-up study

Purpose To investigate whether urinary tract infection (UTI) diagnoses assigned in the emergency department (ED) were true UTI infections, characterize hospitalized UTI patients, and analyze the 12-month mortality and institutionalization rates. Methods A retrospective study amon...

Hospital at home enables safe and efficient outpatient management of intensively treated acute myeloid leukemia

Abstract Purpose Patients with acute myeloid leukemia (AML) spend a substantial amount of time in hospital while receiving intensive chemotherapy, affecting their quality of life and healthcare costs. This study evaluated the safety of outpatient management of febrile neutropenia...

Pelvic injuries in elderly trauma patients: epidemiology, injury characteristics, in-hospital care and factors influencing mortality

Abstract Background Pelvic and acetabular fractures are increasing in incidence in elderly patients. Whether the fracture contributes independently to mortality, or merely accompanies the factors that drive it, remains contested, and large national data on elderly trauma patients...

Effectiveness of a digi-physical tool and working method for paediatric obesity treatment in Abu Dhabi: a non-inferiority intervention study using an external historical comparator

Abstract Background Effective paediatric obesity treatment requires high intensity, scalable interventions. A digi-physical tool for paediatric obesity treatment has shown positive results in Stockholm, Sweden. This study evaluates whether the same treatment method is effective i...

Machine Learning in Traumatic Brain Injury: Dynamic Prediction from Continuous Physiological Monitoring and ICU Data

BACKGROUND: Continuous physiological monitoring in neurocritical care generates large volumes of high-frequency time-series data that remain underutilized in routine traumatic brain injury (TBI) management. Machine learning (ML) approaches applied to these data have emerged as a...

Prevalence and Determinants of Never Treatment During Mass Drug Administration for Lymphatic Filariasis: A Systematic Review and Meta-Analysis

Objectives: The term “never treated” refers to individuals who self-report having never ingested tablets during any round of Mass Drug Administration (MDA) against Lymphatic Filariasis (LF). This study estimated the pooled prevalence of never-treated individuals with MDA for LF a...