Karolinska Institutet

Resilience and adaptation of cancer screening programs to external crises

Objectives To examine how cancer screening programs resumed during the COVID-19 pandemic, focusing on their resilience in terms of coordination, communication, recovery, participation rates, catch-up efforts, inequities, and preparedness. Setting Cancer screening programs represe...

Association of salivary matrix metalloproteinase-8 with metabolic syndrome in women at high GDM risk

Abstract Background To assess associations between metabolic syndrome (MetS), insulin resistance, and periodontal diseases with salivary active matrix metalloproteinase-8 (aMMP-8) in metabolically high-risk women. Methods A total of 112 women with a history of high gestational di...

Extra-Endocrine Features in Infancy as Early Clues to MEN2B

Multiple endocrine neoplasia type 2B (MEN2B) is a rare autosomal-dominant cancer predisposition syndrome in which prognosis is strongly influenced by the stage of medullary thyroid carcinoma at diagnosis. Virtually all affected children exhibit 1 or more extra-endocrine features...

Sleep disturbances as early indicators of incident psychiatric disease

PURPOSE: Sleep disturbances are common in individuals with psychiatric diseases and may emerge years before diagnosis. It remains unclear whether they reflect modifiable risk factors or early manifestations of psychiatric illness. We aimed to investigate how different sleep dimen...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...

Occupational exposure to noise and depression incidence: a nationwide cohort study of workers in Denmark, 2000–2017

Objectives Research on the association between occupational noise and incident depression is limited. We investigated whether long-term occupational noise was associated with depression risk, both independently and in combination with other stress-related factors. Methods In a Da...

Universalism and its Others: Transcultural psychiatry and Swedish exceptionalism after 1945

This article traces the historical development of transcultural psychiatry in Sweden from the post-Second World War period to the early 21st century. It argues that the field emerged at the intersection of welfare universalism, humanitarian internationalism, and clinical encounte...

Treatment Preferences in Acute Allergic Reactions—How Can the Context Impact the Preference for a Corticosteroid Mouth Film Versus Conventional Tablets?

Background: The objective was to assess how preferences for a self-dissolving dexamethasone mouth film versus conventional tablets for acute allergic reactions may vary according to population characteristics and the level of outcome knowledge for the intervention (i.e., ex ante,...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Prognostic significance of isolated tumor cells and nodal tumor burden in endometrial cancer: a population-based cohort study

BACKGROUND AND PURPOSE: Since the introduction of sentinel lymph node biopsy, nodal assessment has expanded to nearly all women with endometrial cancer. However, evidence on the prognostic significance of isolated tumor cells (ITCs) and nodal tumor burden remains limited. We ther...

Problem gambling and affected others: health, relational and economic outcomes across longitudinal trajectories in a population-based Swedish study

Abstract Background Exposure to another person’s gambling problems has been linked to a range of adverse outcomes among affected others (AOs); however, most evidence is based on cross-sectional studies. Less is known about how such outcomes vary over time and across different pat...

Reexamining the Association of Cardiovascular Disease With Neurodevelopmental Disorders in Offspring—Reply

In Reply We thank Dr Karachaliou for her thoughtful comments regarding our study1 investigating whether parents of children with neurodevelopmental disorders (NDDs) have an increased risk of cardiovascular disease (CVD). We appreciate the opportunity to share our view on the poin...

Increased salivary levels of TNF-α and IL-10 in patients with Crohn's disease

Background and objective Salivary cytokines can provide information about oral health and systemic diseases. We aimed to assess the salivary concentration of inflammatory cytokines in outpatients with Crohn's disease (CD) and whether the levels are modified by the presence of per...

Human ticklishness is a widespread, culturally shared and bodily organized sensory experience

Abstract Human ticklishness is one of the oldest yet unresolved scientific puzzles. As early as the time of Aristotle and Socrates, scholars have speculated on its origins and function, but fundamental questions remain. Is ticklishness culturally shared or specific? Does it follo...

Difelikefalin Treatment in Chronic Kidney Disease-Associated Pruritus: Modelling Infection-Related Hospitalisation Cost Offsets Using Trial and Real-World Data Across Seven European Countries

INTRODUCTION: We estimated cost offsets from treating moderate-to-severe chronic kidney disease-associated pruritus (CKD-aP) with difelikefalin, through reduced infection-related hospitalisations (IRHs). METHODS: Using Stockholm CREAtinine Measurements study data, IRH rates were...

Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers

Abstract Background Despite the high prevalence and clinical significance of emphysema, few genetic risk loci have been consistently replicated. We conducted a genome-wide association study (GWAS) of CT-based emphysema, with a particular focus on non-smoking-related genetic deter...

Patients’ experiences of living with the risk of Alzheimer’s disease – a multicentre qualitative study

Aims and objectives To explore the experiences of receiving and living with a diagnosis of prodromal Alzheimer’s disease. Background Alzheimer’s disease is a progressive dementia disorder, with pathology potentially developing years before clinical symptoms. Evidence concerning p...

Exposure to workplace bullying and violence/threats of violence and subsequent working life expectancy among older workers: A Swedish prospective cohort study

OBJECTIVES: This study aimed to quantify possible associations between exposure to workplace bullying and violence, or threats thereof, and working life expectancy (WLE) among older workers in Sweden. METHODS: We conducted a prospective cohort study using data on 12 920 individua...

Social determinants of health and lifestyle in the progression of degenerative bone and joint diseases: a prospective multi-state analysis

Abstract Aims The role of social determinants of health (SDOH) in the progression of degenerative bone and joint diseases (DBJDs) - from initial onset to multimorbidity and mortality - remains unclear. We aimed to assess the associations of SDOH with DBJDs progression, examine th...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...