Karolinska Institutet

Meeting lifestyle recommendations among cancer survivors – a cross-sectional descriptive analysis from the Swedish CArdioPulmonary BioImage study (SCAPIS)

PURPOSE: This study aimed to describe lifestyle patterns in relation to recommendations -including physical activity, diet, smoking, alcohol consumption, and sleep quality-among Swedish cancer survivors, stratified by sex and age. METHOD: A descriptive cross-sectional study was p...

Here it is everything at once: a qualitative study of district nurses’ experiences caring for older individuals with multiple chronic health problems in primary care

Abstract Background Over the next 10-year period in Sweden, the number of people aged 80 and older is will increase by about 50%. The care needs of the population are changing as more people live at home longer with chronic conditions. District nurses in primary care often have t...

Socioeconomic status and longitudinal neurocognitive outcomes following childhood brain tumour diagnosis: a Swedish national population-based cohort study

Abstract Background Lower socioeconomic status (SES) is linked to poorer neurocognitive development in the general population, but these effects in paediatric brain tumour survivors are underexplored. We examined the relationship between parental SES, clinical factors, and neuroc...

Sustainable Assistive-Technology Procurement in Swedish Public Healthcare: Tensions and Paradoxes in Managers’ Decision-Making

Assistive technology (AT) supports participation, independence, and well-being but also presents sustainability challenges for public healthcare organisations. This qualitative study explored sustainability tensions and paradoxes arising in AT decision-making. Semi-structured int...

Gut microbial metabolism of peanuts generates immunoregulatory metabolites

Background. Complementary feeding practices and timing are thought to significantly influence early life immune development, with the early introduction of allergenic foods being especially important for prevention of food allergy. We hypothesized that allergen-containing foods s...

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

Abstract G protein–coupled receptors (GPCRs) rely on dynamic conformational ensembles to coordinate G protein activation and recruitment of regulatory transducers such as GPCR kinases and β-arrestins. The oxysterol receptor GPR183 has been implicated in hematological malignancies...

Using dapagliflozin to reduce symptoms in transthyretin cardiac amyloidosis: An n-of-1 trial series pilot study

Background The role of guideline-directed medical therapy for heart failure (HF) is unclear in transthyretin amyloid cardiomyopathy (ATTR-CM). Dapagliflozin has demonstrated beneficial effects across HF phenotypes, and retrospective studies suggest potential benefit in ATTR-CM; h...

Gender-Affirming Medical Treatment Prevalence, Decision Satisfaction, and Future Need Among Transgender Adults

This survey study documents the prevalence of gender-affirming treatment experiences among adults identifying as transgender in Sweden.

System-level design trade-offs in magnetic hyperthermia RF instrumentation: a power electronics and electromagnetic design review

Abstract Purpose Magnetic hyperthermia (MH) is a promising localized cancer therapy based on magnetic nanoparticle (MNP)-mediated heating. Although research has extensively focused on MNP development, therapeutic efficacy and safety also depend critically on the engineering of th...

Colonoscopy quality indicators among nurse endoscopists and physicians in population-based colorectal cancer screening in Sweden

Background In Sweden, a nationwide colorectal cancer (CRC) screening program for individuals aged 60–74 started in 2021; to meet the increasing demand for colonoscopy, nurse endoscopists may play a key role – provided they maintain high technical quality. This observational study...

Employment status and occupation are associated with liver cirrhosis: A nationwide Swedish case–control study

Abstract Background Liver cirrhosis is often diagnosed in working‐age adults and carries a poor prognosis. A better understanding of variation by employment status and occupation may support earlier and more targeted diagnostic evaluation. Objectives To assess the odds of liver c...

Low Parental Income During Childhood Is Associated With Coronary Atherosclerosis in Midlife

Background Socioeconomic status (SES) is a major risk factor for coronary heart disease, but the life‐course mechanisms and causal pathways remain poorly understood. Therefore, we investigated whether low childhood SES was associated with midlife coronary atherosclerosis and if a...

Latexin deletion in the bone marrow niche suppresses leukemia via LIFR downregulation and immune activation

Acute myeloid leukemia (AML) is the most common adult leukemia diagnosis. Bone marrow (BM) niche significantly influences the initiation and progression of AML. However, our knowledge about the effect of leukemic niche on leukemia stem cells (LSC) and leukemogenesis is limited. I...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Adiponectin-enriched liver-derived ECM attenuates fibrogenic features of activated hepatic stellate cells in a multicellular 3D model

Abstract Background Adiponectin (ADPN), an adipocytokine expressed in multiple tissues including the liver by quiescent hepatic stellate cells (HSCs) has recognized antifibrotic properties. However, most studies rely on simplified 2D systems that fail to capture the liver microen...

Beyond CD4 counts: Multi‐biomarker assessment of estimated time since HIV ‐1 infection and risk factors for late diagnosis

BACKGROUND: Late diagnosis (LD) of HIV, defined as CD4 count <350 cells/μL or AIDS at diagnosis, remains a substantial public health challenge, with half of individuals in Europe diagnosed late. How long these individuals have lived with HIV remains unclear. We applied a multi-bi...

Deep phenotyping of white matter tissue composition in dementia with Lewy bodies

Abstract Background White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue C...

Physiological determinants of endurance capacity in individuals with cerebral palsy: a narrative review

OBJECTIVE: To synthesize evidence on the physiological determinants of endurance capacity in individuals with cerebral palsy. DESIGN: Narrative review. SUBJECTS/PATIENTS: Children and adults with cerebral palsy across the spectrum of motor function (Gross Motor Function Classific...

Efficacy of Local Treatment in Patients With Rheumatic Diseases Affecting the Temporomandibular Joint—A Systematic Review

ABSTRACT Background Temporomandibular joint (TMJ) involvement in rheumatic inflammatory arthropathies (RIA) has been sparsely described, and evidence regarding local treatment options for affected TMJs remains limited. Objectives To perform a systematic review (SR) regarding loca...

Perceived Barriers to Help‐Seeking for Eating Disorders Among Adults With Self‐Reported Eating Disorder Symptoms in Sweden

ABSTRACT Objective Help‐seeking for eating disorders (EDs) remains low despite their burden and the importance of early intervention. This multimethod study examined perceived barriers to help‐seeking among adults with self‐reported ED symptoms in Sweden, a context underrepresent...