Karolinska Institutet

MUC5AC in pancreatic cancer and precursors: a systematic review and meta-analysis

Abstract Background Mucin5AC (MUC5AC) is a secretory glycoprotein that is highly expressed in pancreatic cancer and precursors. We assessed its diagnostic accuracy in differentiating pancreatic cancer and precursors from normal pancreas and benign pancreatic diseases. Methods Sys...

Exploring individual, interpersonal, community, and environmental correlates of active commuting to school among Spanish adolescents: the PACO study

Objectives To identify and analyze the individual, interpersonal, community, and environmental factors associated with active commuting to school (ACS) among Spanish adolescents, and to examine the contribution of correlates from multiple ecological domains to ACS. Methods A tota...

Platelet-Rich plasma for adhesive capsulitis: An umbrella review of effects on pain, function, and range of motion

Background Adhesive capsulitis is a common and disabling shoulder condition with substantial impact on pain and function, yet the role of platelet-rich plasma (PRP) injections remains uncertain. Objective This umbrella review aimed to synthesize the evidence on the effects of PRP...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Efficacy of HER2-targeted therapy in early breast cancer 2008–2020 in Sweden in the real-world setting

Abstract Large-scale real-world evidence on outcomes in HER2-positive (HER2 +) early breast cancer (EBC) remains limited. We investigated overall survival (OS) and its prognostic factors in patients with HER2+ EBC. We here analyzed data from 4,638 patients with HER2 + EBC diagnos...

Exploring dietary patterns during school hours in Swedish adolescent student population, focusing on out-of-school eating and snacking: a repeated cross-sectional study

Abstract Background Establishing healthy dietary habits during childhood and adolescence is essential, as these patterns often persist into adulthood and influence long-term health. In Sweden, school lunches play an important role in overall nutritional intake. However, among ado...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

A coherent family support model (Co-Fam) for preventing and treating childhood overweight and obesity: protocol for a randomized hybrid type 2 effectiveness-implementation trial

Abstract Background Swedish child healthcare involves school health services, primary healthcare, and pediatric clinics. Family-based programs addressing child diet, eating behavior, parental feeding practices and physical activity show promise for preventing and treating overwei...

Congenital TORCH Infections and Neurodevelopmental Outcomes

Importance Congenital TORCH (toxoplasmosis, syphilis, rubella, cytomegalovirus, or herpes simplex) infections are established causes of severe fetal injury, yet their population-level contribution to neurodevelopmental and psychiatric outcomes, independent of familial confounding...

Risk of psoriasis in patients treated with dupilumab for bullous pemphigoid: A cohort study

The data underlying this article were provided by TriNetX under licence and by permission. Data sharing upon request to TriNetX via the corresponding author.

Design, Synthesis, and Antimicrobial Activity of Novel Cyt- bd Inhibitors Targeting Energy Compensation in Mycobacterium tuberculosis

Abstract Drug-resistant Mycobacterium tuberculosis (Mtb) poses a growing threat, necessitating new therapeutic strategies. The cytochrome bcc-aa3 oxidase (Cyt-bcc) is an attractive target, yet single-agent inhibition fails owing to compensation by the alternative cytochrome bd te...

DARE to wear: digital health promotion and disease prevention using wearable devices

Global healthcare systems are under increasing strain to ensure long-term sustainability, necessitating a transition towards proactive, preventive healthcare strategies. Wearable sensor technologies are uniquely positioned to facilitate this paradigm shift by allowing continuous...

Chief operating officers: Exploring a new managerial role in healthcare

Background The rise of Chief Operating Officers (COO) in healthcare is filled with the expectation to improve demand and capacity management practices from a system perspective. Given the absence of empirical studies on the role of COOs in healthcare, this study explores the esta...

Satisfaction with treatment decision-making and long-term experiences of life-prolonging treatments for metastatic castration-resistant prostate cancer

BACKGROUND: Treatments in the phase of metastatic castration-resistant prostate cancer (mCRPC) aim to prolong survival and reduce the symptom burden. The fast development of life-prolonging therapies makes treatment decision-making (TDM) complex, weighting survival against possib...

Identifying drug‐resistant epilepsy using Swedish National Patient Registry data

Abstract Background Approximately 30% of individuals with epilepsy are drug‐resistant, suffering low quality of life and should be evaluated for other treatment modalities. Drug‐resistant epilepsy has no specific diagnostic code, making identification in national healthcare regis...

A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol

Background Adoptive T cell therapy is a promising alternative to conventional therapies for certain solid tumours. Personalized tumour-trained lymphocytes (pTTL) is an autologous T cell therapy derived from tumour-draining regional lymph nodes (RLNs), trained to target patient-sp...

MonoXtract: A Deep Learning Framework for Extracting Transmembrane Protein Dynamics from Single-Color Single-Molecule Imaging

Abstract Single-color fluorescence-based single-molecule techniques enable label-efficient probing of membrane-associated biomolecular dynamics. However, extracting reliable kinetic information is challenging due to signal heterogeneity, noise and the absence of reference channel...

Health co-benefits of sustainable dietary transitions to reduced red and processed meat intake in the United Kingdom: a modelling study

Abstract Purpose Reducing meat intake and increasing plant-based food consumption are priorities for chronic disease prevention and environmental sustainability across Europe. Previous modelling has outlined how policy interventions could shift dietary patterns to align with meat...

Documentation-related diagnostic safety concerns in primary care: a structured medical record review of 1116 patient records

Background Diagnostic safety concerns are among the most consequential yet least visible threats to patient safety in primary care. Non-specific symptoms potentially associated with cancer represent a high-risk context, where delayed diagnosis may have serious consequences despit...

Actualizing the implementation of the underutilized low-cost, life-saving intervention of skin-to-skin contact immediately after birth in a regional referral hospital in Uganda

As a low-resource opportunity to decrease neonatal mortality, skin-to-skin contact during the first hour after birth is an evidence-based best practice which is implemented inconsistently world-wide. As described in the 2023 international research and practice guideline, skin-to-...