Karolinska Institutet

Patient-identified barriers and facilitators to maternal health care in lmics: a qualitative study in Argentina and Ethiopia

Abstract Background Ninety-nine percent of global maternity deaths occur in low-and-middle-income countries (LMICs), despite availability of high quality evidence-based guidelines for common causes of maternal mortality. An understanding of barriers and facilitators (BFs) to acce...

Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function

PAX6 encodes a dosage-sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality. Her...

High sensitivity C-reactive protein and the risk of cardio-kidney outcomes in adults with moderate to severe chronic kidney disease: a nationwide study

BACKGROUND AND HYPOTHESIS: The burden and prognostic significance of inflammation in chronic kidney disease (CKD) remains poorly characterized, with prior studies yielding conflicting estimates of the association between elevated high-sensitivity C-reactive protein (hsCRP) and ca...

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

Effects of dietary quality on type 2 diabetes risk and the mediating role of inflammatory markers

Abstract This study aimed to explore the association between multiple dietary quality indices and diabetes risk and investigate the potential role of systemic inflammatory markers in such relationships. Data were obtained from 21 476 participants in the Fuqing Cohort Study who co...

Lifestyle risk factors for cervical glandular and squamous cell neoplasia: insights from a prospective cohort study of over 117,000 women

Abstract Background While cervical cancer screening has successfully reduced squamous cell carcinoma (SCC) rates, adenocarcinoma (AC) incidence is rising, particularly among younger women. Although SCC and AC differ in genomics and treatment responses, evidence regarding their di...

Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex

Importance Obesity is associated with elevated risks for multiple cancers. How bariatric surgery influences these risks across age and sex is insufficiently understood. Objective To evaluate the association between bariatric surgery and obesity-related cancer (breast, endometrial...

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Autonomic function and signal complexity reflect level and severity of traumatic spinal cord injury

Abstract Study design Observational single-centre cohort study. Objectives To investigate heart rate variability (HRV), baroreflex sensitivity (BRS), and signal complexity (SC) and their relationships with neurological injury level and severity, as well as their prognostic value...

Estimating the Starling equation parameters in living humans by using volume kinetic analysis

Abstract The transcapillary filtration of fluid is governed by the Starling forces. The purpose of the present study was to simultaneously estimate all Starling parameters in living humans by using likelihood mathematics. First, the capillary filtration was estimated by volume ki...

Trajectories of physical activity following digital education and exercise therapy—a longitudinal registry study among 15,197 persons with knee or hip osteoarthritis

Abstract Objective This study examined trajectories of physical activity (PA) and associated factors among individuals with knee or hip osteoarthritis (OA) participating in a digital education and exercise therapy program. We additionally compared patterns of patient-reported out...

ADHD symptoms and learning difficulties: co‐occurrence and directionality from Grades 1 to 9

Background Children with attention‐deficit/hyperactivity disorder (ADHD) are at increased risk of learning difficulties. This association may reflect shared risk factors, ADHD symptoms hindering learning, or learning difficulties increasing ADHD symptoms. We aimed to map rates of...

Addressing Parental Mental Health Problems in Swedish Child Welfare Services: A National Study of Current Practices

Abstract Parental mental health problems can co-occur with child abuse, repeated child protection reports, and adverse child outcomes. Still, limited knowledge exists regarding how child welfare services (CWS) identify and respond to such problems in caregivers . This study exami...

Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11c+ atypical memory B-cells after malaria infection

Abstract Atypical B-cells (ABCs) are observed across infections, yet their ontogeny and differentiation remain unclear. Using high-dimensional flow cytometry, single-cell transcriptomics, V(D)J sequencing, and functional assays in samples from individuals with malaria and healthy...

Validation of diagnostic artificial intelligence models for prostate pathology in a Middle Eastern cohort

Abstract Artificial intelligence (AI) for pathology is accelerating cancer diagnostics. For global adoption, studies in currently under-represented populations – where the potential gains from AI may also be greatest – are needed. We present the first external validation study in...

Invasive Cervical Cancers After an HPV ‐Negative Test: Insights From HPV Testing Histories

ABSTRACT Human papillomavirus (HPV) testing is the primary method for cervical screening, and a negative HPV test is associated with a very low subsequent risk of invasive cancer. Nevertheless, some cervical cancers are diagnosed following an HPV‐negative test. Using Swedish regi...

Long‐COVID Associated With Incident Hypertension: A Population‐Based Cohort Study

Background Long COVID has been linked to persistent autonomic and vascular abnormalities, but its impact on hypertension among non‐hospitalized COVID‐19 convalescents remains unclear. Given the link between blood pressure and cardiovascular morbidity, understanding how long COVID...

Here it is everything at once: a qualitative study of district nurses’ experiences caring for older individuals with multiple chronic health problems in primary care

Abstract Background Over the next 10-year period in Sweden, the number of people aged 80 and older is will increase by about 50%. The care needs of the population are changing as more people live at home longer with chronic conditions. District nurses in primary care often have t...

Meeting lifestyle recommendations among cancer survivors – a cross-sectional descriptive analysis from the Swedish CArdioPulmonary BioImage study (SCAPIS)

PURPOSE: This study aimed to describe lifestyle patterns in relation to recommendations -including physical activity, diet, smoking, alcohol consumption, and sleep quality-among Swedish cancer survivors, stratified by sex and age. METHOD: A descriptive cross-sectional study was p...

Sustainable Assistive-Technology Procurement in Swedish Public Healthcare: Tensions and Paradoxes in Managers’ Decision-Making

Assistive technology (AT) supports participation, independence, and well-being but also presents sustainability challenges for public healthcare organisations. This qualitative study explored sustainability tensions and paradoxes arising in AT decision-making. Semi-structured int...