Karolinska Institutet

Hospital at home enables safe and efficient outpatient management of intensively treated acute myeloid leukemia

Abstract Purpose Patients with acute myeloid leukemia (AML) spend a substantial amount of time in hospital while receiving intensive chemotherapy, affecting their quality of life and healthcare costs. This study evaluated the safety of outpatient management of febrile neutropenia...

A qualitative examination of the content validity and acceptability of the EQ-5D-Y-3L and EQ-5D-Y-5L in adolescents with type 1 diabetes mellitus in Ethiopia

Abstract Background The EQ-5D-Y-3L and EQ-5D-Y-5L are widely used generic measures of health-related quality of life (HRQoL), including among children and adolescents with Type 1 Diabetes Mellitus (T1DM). However, evidence on the measures’ content validity and acceptability in lo...

Immune-checkpoint inhibitor-induced bullous pemphigoid in patients with metastatic renal cell carcinoma: two case reports and systematic review of the literature

BACKGROUND AND PURPOSE: Immune-checkpoint inhibitors (ICIs) improve outcomes in renal cell carcinoma (RCC) but may cause immune-related adverse events (irAEs), including cutaneous toxicity. Bullous pemphigoid (BP) is a rare but clinically significant irAE that can require ICI dis...

Plasma membrane order maps functional diversity in immune cells

Abstract Cell membranes undergo biophysical remodeling as an adaptation to the surroundings and to perform specific biological functions. However, the extent and relevance of such changes in human immune cells remain unknown, largely because of the lack of single-cell and multidi...

Comparison of High‐Sensitivity Troponin T Versus N‐Terminal Pro‐B‐Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery

Background Preoperative hs‐TnT (high‐sensitivity cardiac troponin T) and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) are used for risk prediction in noncardiac surgery. While the European Society of Cardiology recommends hs‐TnT, American Cardiology and European anesthes...

Effect of Construction Restrictions on Future Landslide Exposure Under Land-Use Simulation in Southwest China

Natural hazards significantly influence landscape patterns and ecological processes, yet their integration into land-use simulation remains limited. This study incorporates landslide susceptibility into the Patch-generating Land Use Simulation (PLUS) model to evaluate the effect...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Respiratory symptoms up to 18 months after COVID-19 – a longitudinal observational study

Abstract Background This study aimed to identify, analyse and compare adults with and without respiratory symptoms over time after COVID-19 and identify predictors of persistent respiratory symptoms, in hospitalised and non-hospitalised patients. Methods Participants were recruit...

Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using in utero transduction

How diverse cell lineages emerge and are genetically regulated during organogenesis are central questions in understanding the developmental origins of disease. However, the mouse gut, including its intrinsic enteric nervous system (ENS) derived from migratory neural crest, has r...

Tales of destruction and repair: the changing view of MYC proteins in tumorigenesis

MYC proteins are classically viewed as oncoproteins because they act as DNA-bound transcription factors that drive characteristic gene expression programs. Building on this view, recent work has shown that MYC proteins engage in multiple protein complexes that resolve transcripti...

Impact of guidewire caliber on biliary cannulation outcomes: a prospective randomized comparison of 0.025-inch and 0.035-inch guidewires

Background and aim Guidewire-assisted biliary cannulation is the standard technique for endoscopic retrograde cholangiopancreatography (ERCP). Whether guidewire caliber influences cannulation success or post-ERCP pancreatitis (PEP) remains uncertain. We evaluated whether the 0.02...

Interpreter use in Nordic paediatric oncology care – a multicentre cross-sectional study

BACKGROUND AND PURPOSE: Tailored, language-appropriate information is fundamental for children and their families in paediatric oncology, influencing both the quality of care and clinical outcomes. Yet, for families who speak another language, interpreter services are not used to...

A multi-site study of implementing a school-based health promotion intervention in Sweden – changes in readiness and implementation outcomes

Abstract Background : Effective implementation of evidence-based interventions is essential to reducing the disease burden. Contextual barriers can hinder implementation and reduce effectiveness. Assessing readiness early in the process may identify challenges and improve outcome...

Predicting Radioiodine Therapy Response in Advanced and Recurrent Thyroid Cancer

Radioiodine therapy of differentiated thyroid cancer is effective and possibly curative in patients with metastatic lesions that retain iodine avidity. However, in clinical practice, iodine avidity in any metastatic site is usually unknown at the point of initial treatment. Avidi...

Assessing ethical competence and ethical climate: development and psychometric testing of the Clinical Ethics Support Measurement Instrument (CES-MI)

Abstract Background Clinical ethics support (CES) is increasingly recognised as essential in healthcare, yet its evaluation remains challenging due to the complexity of CES practices and the latent, psychosocial nature of relevant outcomes. The European Moral Case Deliberation Ou...

Impact of Single‐Cell RNA Reference Selection for the Deconvolution of Breast Cancer Spatial Transcriptomics Datasets

Spot-based spatial transcriptomics (ST) allows for unbiased gene expression analysis within tissue architecture, overcoming the limitations of single-cell RNA sequencing (scRNA-seq) by preserving spatial context. However, the high spatial resolution in ST leads to cellular hetero...

The impact of the COVID-19 pandemic on emergency department visits in region Stockholm: a population-based study between 2018-2021

BACKGROUND: As COVID-19 cases increased, organizational changes were implemented in Emergency Departments (EDs) to manage the expected demand. However, the impact of these changes on ED utilization is not understood. This study aims to examine the pattern of hospital-based all-ca...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Childhood inductive reasoning, cardiovascular and cardiometabolic morbidity and dementia risk – a population representative cohort study across six decades

Abstract Background Higher cognitive ability in late adolescence and young adulthood associate with reduced risk of dementia, but such assessments are influenced by educational selection. Whether specific cognitive abilities earlier in childhood associate with later dementia risk...

Optimising Human Papillomavirus Vaccination Strategies for Faster Cervical Cancer Elimination

ABSTRACT Aim Cervical cancer elimination is a global public health goal, with vaccination against Human Papillomavirus (HPV) and HPV screening being two major prevention pillars. This review focuses on how vaccinations can be used in order to reach the timepoint of cervical cance...