Karolinska Institutet

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence

BACKGROUND: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study compared adherence, healthcare resource utilization (HCRU),...

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid or...

The tumour microenvironment influences long-term tamoxifen benefit in postmenopausal ER+/HER2− breast cancer patients: a secondary analysis of the randomised Stockholm Tamoxifen (STO-3) trial

Abstract Background The tumour microenvironment (TME) influences breast cancer progression and treatment response. We investigated whether TME composition predicts tamoxifen benefit in postmenopausal women with oestrogen receptor-positive, HER2-negative (ER+HER2-) breast cancer....

Loneliness trajectories surrounding mobility loss: The role of disability duration

Abstract Objectives Mobility limitations in later life can disrupt social engagement and increase loneliness, but trajectories may differ depending on whether limitations remain or individuals recover. This study examines loneliness trajectories around the onset of mobility limit...

The mirrored burden and accountable handovers in cancer survivorship: co‑designing a post‑treatment transition standard

Post-treatment transitions after active cancer care often lack clear ownership, timelines and closure rules, shifting coordination work onto survivors and staff. We aimed to identify how these failures arise and to co-design a handover standard for post-treatment survivorship car...

Comparison between the blood urea nitrogen (BUN)-to-creatinine ratio and four urinary biomarkers of dehydration; a cross-sectional study in fasting patients awaiting surgery

The blood urea nitrogen (BUN)-to-plasma creatinine ratio is a conventional method for diagnosing dehydration. We examined the relationship between this method and the more recently promoted urine biomarkers of dehydration. Blood and urine sampling was performed in 921 patients wh...

Outcomes of hospitalized children in rural Malawi: investigating the association between inpatient mortality and referral

<ns5:p>Background The under-five mortality rate counted 71 deaths per 1000 live births for children under five in Sub Saharan Africa in 2022, far above the SDG under five-mortality goal of 25 deaths per live 1000 birth. Referral issues are major challenges to child health and the...

The success of dental implants in patients with systemic conditions. A retrospective clinical study

Background Systemic alterations are highly prevalent in the population and may interfere with peri-implant repair. Purpose The aim of this study was to investigate the association between systemic conditions with the loss of dental implants. Materials and methods This is a retros...

Health4Life: a digital intervention to promote healthy diet and movement behaviours from the start of life: protocol for a hybrid effectiveness-implementation study

Abstract Background Globally and in Sweden childhood overweight and obesity remain major public health issues. The first 1000 days (i.e., conception-24 months) has been identified as the period of greatest developmental plasticity, with the maximum capacity to influence health th...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Impact of intraoperative CT on implant accuracy and reoperation rates in orbital floor reconstruction

BACKGROUND: Implant malposition is a leading cause of reoperation after orbital floor reconstruction. Intraoperative computed tomography (CT) enables immediate assessment and correction, however its impact on implant positioning accuracy and outcomes remains insufficiently studie...

α ‐Hydroxybutyrate Association With Incident Type 2 Diabetes Over 10 Years Across Different Glycemic States

ABSTRACT Aim To investigate the association between baseline plasma α‐hydroxybutyrate (α‐HB), an organic acid derived from aminoacid catabolism and glutathione anabolism, and the 10‐year incidence of Type 2 diabetes (T2DM). Materials and Methods This prospective study analysed 13...

Beyond Amyloid: Systemic and Brain Frailty as Determinants of Response to Anti-Amyloid Therapy in Alzheimer’s Disease—A Conceptual Review

Anti-amyloid therapy (AAT) with monoclonal antibodies (mAbs) modestly slow cognitive and functional decline in early Alzheimer’s disease (AD). However, both the magnitude of clinical benefit and the risk of treatment-related complications vary substantially even among patients wi...

Navigating the Role of Radiotherapy for Extremity Soft Tissue Sarcomas

Background/Objectives: The basis for treatment of sarcoma is surgical resection. However, since the introduction of limb salvage surgery, guidelines recommend radiation as a complement to surgery for high-grade sarcomas. The aim of the present narrative review was to provide a co...

Beyond the 90 Reserved Days for Each Parent: Associations Between Fathers' Parental Leave Duration and Depression Symptoms in a Swedish National Cohort Study.

. 2026;116(8):1121-1129. https://doi.org/10.2105/AJPH.2026.308589).

Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring

Abstract Liquid biopsy has emerged as a transformative development in oncology, enabling the minimally invasive detection and monitoring of cancer through the analysis of tumor-derived material in blood. Moving beyond single-variable analysis, multifeature sequencing-based liquid...

Hepatic encephalopathy associated with extensive hepatic diaphragmatic herniation in an adult horse

Abstract Background Diaphragmatic hernia in horses is a rare condition, most commonly presenting with signs of colic and, less frequently, respiratory compromise. Hepatic herniation through a diaphragmatic defect with secondary hepatic failure and encephalopathy has rarely been d...

Assessment of Trophoblast cell surface antigen 2 (Trop-2) expression and its clinical significance in breast cancer: a multi-level analysis of protein and gene expression

Abstract Background Trophoblast cell surface antigen 2 (Trop-2) is a targetable transmembrane glycoprotein commonly overexpressed in breast cancer (BC). This study combines a systematic review and meta-analysis with a retrospective analysis of an independent early BC patient coho...

Antibiotic Prescribing Among Inpatients with Ophthalmic Diagnoses: A Decade of Evidence from Two Private-Sector Indian Hospitals

Objectives: To describe and compare decadal antibiotic prescribing patterns and trends by diagnosis groups among ophthalmology inpatients at two private-sector hospitals in Central India. Methods: This observational surveillance study was conducted prospectively for a decade in t...