Karolinska Institutet

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated genes, biological pathways, and potential etiologic factors. Methods We performed a cross-populatio...

Fibrinoid-associated neutrophils promote invasive placentation and neutrophil reprogramming at the maternal-fetal interface

Successful early pregnancy depends on coordinated interactions between the placenta and maternal immune cells, but the mechanisms underlying this interplay remain incompletely understood. Placenta-derived extravillous trophoblasts (EVTs) invade the decidua basalis and remodel mat...

Ergothioneine-Associated Transcription Opposes Conserved Mitochondrial Injury Programs in Proximal Tubules

Acute kidney injury (AKI) is characterized by tubular epithelial stress, inflammation, and metabolic dysfunction, yet the transcriptional programs associated with effective metabolic recovery remain poorly defined. Ergothioneine (EGT) has demonstrated renal and mitochondrial prot...

The 2026 ESC heart failure guidelines: advancing science while facilitating clinical implementation

The 2026 European Society of Cardiology (ESC) guidelines for the management of heart failure introduce a series of important changes intended to simplify classification, accelerate implementation of effective therapies, and shift care toward earlier prevention and intervention. A...

Skeletal muscle dedifferentiation requires centrosomes

Multinucleated skeletal muscle cells are stably withdrawn from the cell cycle in most vertebrates. Muscle dedifferentiation, however, naturally occurs during limb regeneration in newts and can be experimentally induced in mammalian myotubes. Here we addressed the dynamics of cent...

Frailty and longitudinal pulmonary function trajectories in lung transplant recipients

Abstract Background Frailty is increasingly recognized as a marker of biological vulnerability associated with adverse clinical outcomes. Lung transplant recipients may be particularly susceptible to frailty, yet its impact on longitudinal pulmonary function improvement after tra...

Difficulties falling asleep and psychosocial factors among Swedish adolescents aged 11–15 years: A population-based study

Aim: To investigate the associations of difficulties falling asleep with problematic social media use, cyberbullying, and mental well-being among Swedish adolescents aged 11–15 years and to explore age-related differences while adjusting for gender and perceived family financial...

The NorthMom study: population-based follow-up of women in a birth cohort to assess pregnancy exposures and effects on breast cancer risk factors

Abstract Background The NorthMom Study (NorthMom) is an observational, population-based cohort designed to determine how the environment during pregnancy affects later health risks among women. The specific focus of NorthMom is breast cancer risk, evaluated through intermediate m...

Effect of pea protein-enriched snacks and vitamin D supplementation on the progression of sarcopenia in elderly subjects: study protocol of the SARC-PEA randomised controlled trial

The progressive ageing of the population (age > 65 years) underscores the urgent need for effective strategies for the prevention of sarcopenia, a condition characterised by the gradual loss of muscle mass and muscle strength and a decline in physical performance. Adequate intake...

Trait Sport Anxiety as the Only Consistent Predictor Across Injury Mechanisms in Young Taekwondo Athletes: A 6- to 10-Month Prospective Cohort Study

Background: Injury prevention in combat sports has focused primarily on physical and biomechanical factors, whereas psychological determinants remain understudied. Because taekwondo involves both contact and noncontact injury mechanisms, a biopsychosocial approach may better expl...

Atlas of cell types and regulatory elements underlying human facial diversity

Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we create...

Quantifying uncertainty: a practical comparison of Bayesian and frequentist meta-analytic frameworks applied to lead exposure and children’s IQ

Abstract Background Uncertainty quantification is central to evidence synthesis for risk assessment and policy-making. Frequentist meta-analysis - currently predominant in epidemiology - quantifies uncertainty through confidence intervals, while Bayesian meta-analysis provides po...

Indirect derivative fast Padé transform applied to magnetic resonance spectroscopy

Abstract This article is on lineshape profiles by indirect derivatives of spectra reconstructed from time signals or free induction decay (FID) data encoded by magnetic resonance spectroscopy (MRS). Only the nonparametric reconstructions (shape estimations) are performed using fo...

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

Importance Probiotics are reported to benefit preterm infants, but population-based clinical evidence is limited. In 2020, the Swedish Neonatal Society issued a national recommendation to supplement very preterm infants (28 weeks 0 days’ to 31 weeks 6 days’ gestation) with probio...

Socioeconomic Status and Working Life Expectancy: A Swedish Cohort Study

Abstract Longer life expectancy and fertility decline raise several potential challenges for national economies and the security of welfare systems. Raising retirement ages, or ages of eligibility for state pension, is one strategy to offset rising costs. Yet, considerable subgro...

An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts

Abstract Cancer-associated fibroblasts (CAFs) promote tumorigenesis and represent potential therapeutic targets, highlighting the need for precise understanding of CAF heterogeneity. In colorectal cancer (CRC), CAF subsets and nomenclature vary widely, and many studies overlook t...

How I do it: microsurgical extraforaminal sequestrectomy through a midline intertransverse approach

Abstract Background Several surgical approaches exist for extraforaminal (far lateral) lumbar disc herniations, including paraspinal Wiltse-type, interlaminar, lateral intertransverse, and combined medial–lateral techniques. Method We present microsurgical extraforaminal sequestr...

Lifetime substance use disorder and suicidal behaviour: a population-based familial co-aggregation register study

Abstract Substance use disorders (SUD) are associated with suicidal behaviour, but less is known regarding the extent to which familial factors influence these associations across different types of SUD. We performed a national register study including 4,209,615 individuals born...

Household consumer purchases and chronic disease

Chronic disease risk stratification remains costly and often provides limited insight into modifiable exposures. Consumer purchases are routinely generated, low-burden measures of household lifestyle that can be linked to health outcomes with consent. In this Danish cohort study,...

Efficacy of HER2-targeted therapy in early breast cancer 2008–2020 in Sweden in the real-world setting

Abstract Large-scale real-world evidence on outcomes in HER2-positive (HER2 +) early breast cancer (EBC) remains limited. We investigated overall survival (OS) and its prognostic factors in patients with HER2+ EBC. We here analyzed data from 4,638 patients with HER2 + EBC diagnos...