Karolinska Institutet

Longitudinal associations of objectively measured sedentary behaviour and physical activity intensities with urinary incontinence among middle-aged women: a cohort study

Abstract Background Urinary incontinence is a prevalent condition among middle-aged women, yet its relationship with activity behaviours remains underexplored. This study aimed to explore the longitudinal associations between objectively measured sedentary behaviour and physical...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making

Abstract Emotional reactions to norm violations influence how people trade-off selfish interests against social norms, but it remains unknown which brain regions contribute to integrating physiological (e.g., heart rate) responses to norm violations into the decision process. Her...

Humans: Intertwined with life and the basic elements in the Anthropocene biosphere

Abstract The notion of people and nature as intertwined and embedded in the biosphere is gaining traction in contemporary scientific discourses. But what does it mean for a human being to be intertwined? Here, we explore this question through two lenses: looking at the human body...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

Heavy-tail-aware representation learning and dynamic Bayesian state modelling to derive an operational proxy definition of problem gambling risk from routine online gambling data

Abstract Background: Problem gambling causes harm, but operational identification often relies on heuristic thresholds or sparse manual reviews. Routine online gambling logs are heavy-tailed and temporally structured, complicating risk definition and early detection. Methods: We...

Vaping and smoking in individuals with eating disorders: associations with diagnoses and behaviors

Abstract Background Smoking commonly co-occurs with eating disorders (EDs) but less is known about the relationship between EDs and vaping. We investigated associations of lifetime vaping and smoking as forms of nicotine use with lifetime ED diagnoses (i.e., anorexia nervosa [AN]...

Associations Between Genetic Variants in the 17q21 Locus, CDHR3 and Childhood Asthma

Background Previously identified asthma-susceptibility genes account for a small part of asthma heritability and their role in asthma pathogenesis is unclear. We explored associations between genetic variants in the 17q21 locus, CDHR3 (cadherin-related family member 3) , coding a...

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

Abstract Polycystic ovary syndrome (PCOS) is characterized by reproductive and metabolic disturbances and is associated with increased symptoms of anxiety and depression. Circulating adiponectin, an insulin-sensitizing adipokine, is reduced in women with PCOS, and low adiponectin...

The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-analysis

Abstract Introduction Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Social protection interventions can benefit TB-affected households. We conducted a systematic review and meta-analysis to quantify the effectiveness of social protection on...

Development and external validation of a machine-learning risk model for colorectal cancer triage in Sweden’s fast-track pathway

Abstract Background Fast-track colonoscopy pathways detect colorectal cancer (CRC) but strain endoscopy capacity. We developed and externally validated multivariable risk models combining faecal immunochemical test (FIT) with clinical data to triage Swedish fast-track referrals....

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using nationa...

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

OBJECTIVE: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (B...

Adherence to the Mediterranean Diet and Academic Performance in University Students: A Systematic Review and Meta-Analysis

Background/Objectives: Adherence to the Mediterranean diet (MedDiet) has been associated with numerous health benefits, yet it is often suboptimal among university students. Its relationship with academic performance (AP), an outcome with potential long-term implications, has not...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

The Impact of Out-of-Hours Liver Transplantation on Outcomes

Objectives: This national, multicenter retrospective study of 764 adult liver transplantations (LT) in Sweden (2019–2023) employed a data-driven approach to identify the out-of-hours (OOH) high-risk window and evaluate its impact on patient outcomes and health care costs. Summary...

Food choices and beliefs in adults with inflammatory bowel disease in Sweden

Abstract Objectives Diet is a recognised risk factor for inflammatory bowel disease (IBD) and a management strategy. Concerns persist regarding the adverse effects of restrictive diets, including nutritional deficiencies and selective eating. The impact of IBD on patients’ belief...

Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance training-induced hypertrophy

Skeletal muscle hypertrophy is a hallmark of resistance training that improves health and longevity. However, despite physiological differences between sexes and fiber types, the underlying proteome changes with resistance training have not been studied in a sex- and fiber type-s...

Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study

ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...

Women’s lived experiences of the built environment and maternal psychosocial well-being in urban slums and slum rehabilitation colonies: a qualitative study in Bhopal, India

BACKGROUND: Nearly half of India's urban population lives in informal settlements, facing substandard living conditions due to overcrowding, poor infrastructure, and limited access to basic amenities. These conditions critically affect the psychosocial well-being of mothers, yet...