Harvard University

The psychological impact of traumatic invalidation among U.S. Jewish adults after October 7, 2023

This study examined traumatic invalidation (TI), the extreme dismissal of an individual’s experiences, characteristics, or beliefs, specifically in the Jewish community. We investigated the prevalence and psychological impact of identity-based TI among 733 Jewish adults in the Un...

Five-Year Cost-Effectiveness Analysis of Endoscopic Third Ventriculostomy With Choroid Plexus Cauterization Versus Ventriculoperitoneal Shunting in Postinfectious Hydrocephalus in a Low-Income Setting

BACKGROUND AND OBJECTIVES: For over 2 decades, an emerging body of data has established endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) as a viable option in the treatment of postinfectious hydrocephalus (PIH) in low-resource settings with similar out...

Robust changes in brain function require high D2 receptor occupancy by prochlorperazine: an imaging correlate for the antipsychotic therapeutic window

Abstract The dopamine D 2 -receptor antagonist prochlorperazine is approved clinically as both an antipsychotic and an antiemetic. Classical antipsychotics like prochlorperazine have been shown to treat the positive symptoms of schizophrenia at occupancies higher than 60% with ex...

Gibbs state preparation for commuting Hamiltonian: Mapping to classical Gibbs sampling

Gibbs state preparation, or Gibbs sampling, is a key computational technique extensively used in physics, statistics, and other scientific fields. Recent efforts for designing fast mixing Gibbs samplers for quantum Hamiltonians have largely focused on commuting local Hamiltonians...

Federal Funding Cuts and the Future of Health Care in Schools

This Viewpoint discusses threats to and protections for school-based health services.

m6A mRNA methylation regulates pancreatic α-cell plasticity

Pancreatic α-cells are central regulators of glucose and amino acid homeostasis, yet the mechanisms that preserve α-cell identity and function remain incompletely understood. N6-methyladenosine (m6A) is a widespread mRNA modification that is essential for β-cell biology and pancr...

Secondary CNS Lymphoma Masquerading as Recurrent Basal Ganglia Stroke

The basal ganglia comprise a metabolically active group of nuclei implicated in refining movement and emotion. We present the case of a 52-year-old man with common variable immunodeficiency (CVID) who presented to the hospital with severe thrombocytopenia and concern for recurren...

Contribution of Adolescent Movement Behaviours to Socioeconomic Inequalities in Adult Cardiovascular Disease Risk: A Causal Decomposition in a Population-Based Cohort

Abstract Addressing unhealthy movement behaviours in adolescence could reduce socioeconomic inequalities in adult cardiovascular disease (CVD) risk. Among 6608 adolescents enrolled in the Add Health cohort (1994-1995) and followed into adulthood (2016-2018), movement behaviours (...

Optimizing Complete-Arch Implant Rehabilitations: Comprehensive Review of Restorative Protocols

Digital workflows for the restoration of implant supported complete arch prostheses have presented a range of distinct advantages over conventional impression techniques including decreased risk of distortion, enhanced patient experience, and streamlined operational efficiency. H...

Hedonic and eudaimonic pathways of self-forgiveness and suicide-related cognitions in trinidad and tobago: a quantile regression approach

Abstract Self-forgiveness is a multidimensional construct involving both hedonic processes, primarily related to fostering self-compassion and alleviating self-condemnation, and eudaimonic processes, focused on moral repair and value reorientation. While previous research has lin...

Lack of Knee Confidence Is Associated With Lower Functional Scores After Anterior Cruciate Ligament Reconstruction at 2‐Year Follow‐Up

Purpose To evaluate how patients rate their knee confidence after anterior cruciate ligament injury, when confidence in their knee returns after anterior cruciate ligament reconstruction (ACLR), and how knee confidence correlates with self‐reported outcomes related to return to s...

Time to diagnosis of acute kidney injury and its predictors among outborn neonates in India: a competing-risk analysis of tele-ICU network data (2022–2024)

Background There is limited data on neonatal acute kidney injury (AKI) from resource-constrained settings. In this study, we describe time to AKI diagnosis and its predictors among neonates born outside the treating hospital (outborn) in India, accounting for competing events lik...

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activ...

Establishment, Implementation, and Sustainability of Digital Dentistry in Dental Schools

ABSTRACT Digital dentistry technology and its workflows offer important benefits, including advancements in patient care and diagnostic capabilities. Dental schools have been adopting and integrating these advanced technologies into their educational and patient care practices. T...

The evidence challenge facing large language models in medicine

The growing use of large language models (LLMs) in medicine presents challenges for traditional approaches to evidence generation and evaluation. Rapid model development and variation in the design and reporting of prospective clinical studies may pose important challenges for ti...

Multilevel factors associated with nonresponse to patient-reported outcome measures in routine radiation oncology care

Nonresponse to routinely collected patient-reported outcome measures (PROMs) threatens the representativeness of aggregated data. We characterized patient-, provider-, and clinic-level factors associated with PROMIS Global-10 nonresponse in routine radiation oncology care. In thi...

Program-Level Neoadjuvant Chemotherapy Use and 10-Year Survival in Advanced Ovarian Cancer

This comparative effectiveness research examines the association between neoadjuvant chemotherapy adoption by US cancer programs and 10-year survival among patients with advanced ovarian cancer.

Proposing a Grand Bargain for More Affordable Employer-Sponsored Insurance

This JAMA Forum discusses current tax policy, reinsurance for employer coverage, and what could be included in a grand bargain.

Rapid extended-release buprenorphine induction without sublingual stabilization in a shelter-based harm reduction setting for high-risk fentanyl use: a retrospective case series

Individuals with opioid use disorder (OUD) who use illicit fentanyl in shelter-based settings face profound barriers to conventional medications for OUD (MOUD), including requirements for sublingual buprenorphine (SL-BUP) stabilization prior to extended-release injectable bupreno...

“It makes me free”: participant perspectives on HIV prevention and contraception delivery at hair salons in Durban, South Africa

Oral pre-exposure prophylaxis (PrEP) use is low among women, particularly in South Africa (SA), where HIV incidence remains high. Providing integrated HIV prevention with other sexual and reproductive health (SRH) services in community settings may promote uptake and engagement....