Chinese Academy of Medical Sciences & Peking Union Medical College

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Non-opioid pharmacologic interventions for the prevention of delirium after cardiac surgery in adults: systematic review and network meta analysis

Abstract Background Postoperative delirium (POD) is a more common complication of cognitive dysfunction in adults following cardiac surgery, which leads to higher mortality, poor prognosis and increased hospital resource utilization. Given the established correlation between opio...

A dual-wavelength blue laser platform for integrated diagnosis and therapy in glioblastoma: preclinical evidence

Glioblastoma (GBM) remains clinically intractable owing to dismal prognosis and frequent recurrence. This study aimed to develop a dual-wavelength blue laser platform (450 nm and 405 nm) that integrates laser ablation, photodynamic diagnosis (PDD), and photodynamic therapy (PDT)...

Psychological flexibility, neuroticism, and subjective well-being among medical students: a latent profile and mediation analysis

Medical students’ subjective well-being is closely associated with academic stress, psychological flexibility, and neuroticism; however, the heterogeneity of psychological flexibility and the potential indirect association through neuroticism remain underexplored. The present stu...

Deep learning radiomics based on preoperative multiparametric MRI in predicting breast cancer recurrence risk

Breast cancer treatments are often tailored to recurrence risk to improve outcomes, but reliable risk stratification methods are lacking. To predict preoperative breast cancer recurrence risk through a tridimensional synergy model integrating breast MRI, radiomics, and deep learn...

Goblet cell heterogeneity and plasticity in ulcerative colitis: implications for mucus barrier reconstitution

The mucus barrier maintained by intestinal goblet cells is critical for colonic homeostasis, and its disruption is a key pathological hallmark of ulcerative colitis (UC). Goblet cells, once thought to be a homogeneous population of passive mucin secretors, are now recognized as a...

OGTT ‐Derived β‐Cell Function–Based Stratification of 2‐Year Glycaemic Transitions in Chinese Adults With Prediabetes

ABSTRACT Aims Prediabetes is heterogeneous, with variable progression to diabetes or reversion to normoglycemia. We evaluated whether the insulin secretion‐sensitivity index‐2 (ISSI‐2), an oral glucose tolerance test (OGTT)‐derived integrated surrogate of β‐cell function relative...

Sepsis: advances in diagnosis, management, and long-term outcomes—a narrative review

Abstract Sepsis is a complex and highly heterogeneous syndrome that resulted in approximately 11 million deaths worldwide in 2017 due to multiple organ failure, posing a serious threat to human life and health. With the advancement of medical technology, the definition of sepsis...

Multi-omics profiling identifies neuroinflammation-related genes and exosomal miRNA as robust diagnostic signatures for Parkinson’s disease

Neuroinflammation is a pivotal driver that amplifies the pathogenic cascade within the Parkinsonian brain. Nevertheless, the pathogenic drivers connecting neuroinflammation to PD pathogenesis remain unclear. To elucidate their diagnostic and therapeutic implications, this researc...

Deep learning predicts gene rearrangements from histopathology in large B-cell lymphoma

Abstract Large B-cell lymphomas are molecularly heterogeneous mature B-cell neoplasms in which assessment of MYC , BCL2 , and BCL6 rearrangement status contributes to integrated diagnosis, risk stratification, and treatment planning. Fluorescence in situ hybridization (FISH) rema...

Left ventricular end-diastolic diameter to body surface area ratio as a continuous risk marker in left ventricular non-compaction with a dilated phenotype: a multicenter cross-sectional study

Dilated cardiomyopathy (DCM) is a risk factor for poor outcomes in patients with left ventricular non-compaction (LVNC). This study aims to identify key factors associated with the DCM phenotype in LVNC and develop a risk stratification model. This multicenter cross-sectional stu...

Development and external validation of an interpretable machine learning model for high-frequency hearing loss screening

Early identification of high-frequency hearing loss (HFHL) remains difficult in community settings because conventional audiometric screening requires specialized equipment and trained personnel. We aimed to develop, interpret, and externally validate a machine-learning model usi...

Research Advances on Organelle-Targeted Drug Delivery Systems for the Treatment of Brain Tumors and Central Nervous System Inflammation

Central nervous system (CNS) inflammation and brain tumor treatment are constrained by the heterogeneity of the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB), as well as by the sequential barriers to drug delivery across lesions, target cells and subcellular orga...

Carbon Dots as Versatile Nanoplatforms for Ophthalmic Therapeutics

Carbon dots (CDs), an emerging class of carbon-based nanomaterials, have attracted increasing interest in ophthalmology owing to their excellent biocompatibility, unique optical properties, tunable surface chemistry, and superior tissue penetration. These features render CDs high...

Efficacy evaluation of flap repair after radical excision for axillary hidradenitis suppurativa

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Synthetic nanoplatforms for multiscale imaging in living organisms

Abstract The rapid advancements in nanotechnology have promoted transformative breakthroughs in biomedical imaging, with global research in this field exhibiting exponential growth and numerous cutting-edge achievements widely reported. This review systematically summarizes the e...

Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats

Postmenopausal osteoporosis (PMOP) is characterized by excessive bone resorption caused by increased osteoclast activity. Estrogen remains an effective therapeutic option for preventing bone loss; however, its regulatory effects on osteoclast cytoskeletal remodeling have not been...

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-aging compounds from Dengzhan Shengmai formulation

Aging is a complex biological process involving multiple dysregulated pathways, and synergistic compound combinations offer distinct therapeutic advantages through multi-target and multi-pathway interactions. Traditional Chinese Medicine (TCM) formulations are inherently synergis...

PIK3CA promotes hepatic tumor growth through evasion of phagocyte-mediated anti-tumor immunity

Both primary and metastatic liver cancers are highly lethal diseases, for which effective treatment options remain limited. The unique hepatic microenvironment provides a niche that enables tumor cells to evade immune surveillance. To identify factors that mediate tumor growth wi...

Increased receptor binding and spike glycosylation, remodeled immune escape of surging SARS-CoV-2 subvariant BA.3.2.2/RE.2.2/Cicada

SARS-CoV-2 continues to evolve. The subvariant BA.3.2 (Cicada), a derivative of the Omicron BA.3 subtype first detected in late 2024, harbors multiple spike protein mutations, ORF7 and ORF8 deletions, and has recently evolved sublineages (BA.3.2.1 and BA.3.2.2), rendering it a cr...