Chinese Academy of Medical Sciences & Peking Union Medical College

The complete chloroplast genome of Mesosphaerum suaveolens (L.) Kuntze and phylogenetic position in the Lamiaceae family

The complete chloroplast genome of Mesosphaerum suaveolens is 152,555 base pairs long and has a typical quadripartite structure. It contains 132 genes, including 13 cis-splicing genes, 2 trans-splicing genes (rps12), and 8 tRNA genes with introns. A total of 47 simple sequence re...

Demoted CD4+ T-cell activity resulted from CTNNB1 mutations resists lenvatinib plus anti-PD1 in HCC

Abstract Hepatocellular carcinoma (HCC) patients frequently fail to respond to combined anti-PD1 immunotherapy, though pre-existing neoantigen-specific CD8⁺ T cells within tumor microenvironment are reinvigorated upon PD1 blockaded. Tumor-intrinsic mechanisms driving the therapeu...

Intratumoral microbiota: spatiotemporal dynamics, microenvironmental immune reprogramming, and immunotherapeutic implications

The discovery of intratumoral microbiota has challenged the traditional view of tumors as sterile environments and revealed a previously unrecognized layer of complexity within the tumor microenvironment (TME). Accumulating evidence indicates that microorganisms residing in tumor...

Peripheral CD4 + T‐Cell Reserve as a Potential Biomarker of CD20 × CD3 Bispecific Antibody Outcomes and BTK Inhibitor–Associated Immune Modulation in B‐Cell Lymphoma

ABSTRACT Bispecific antibodies (BsAbs) targeting CD20 × CD3 have achieved remarkable efficacy in relapsed or refractory (R/R) B‐cell lymphoma, yet clinical responses remain heterogeneous and predictive biomarkers are lacking. We retrospectively evaluated associations between peri...

TOP2A Overexpression as a Prognostic Biomarker in High-Grade Meningioma: An Integrated Single-Cell and Bulk Transcriptomic Study

While prior single-cell studies have identified proliferative neoplastic subpopulations, the prognostic and therapeutic implications of TOP2A focal copy-number status have not been defined. This study aimed to delineate the cellular architecture of high-grade meningioma and to ev...

Case-generating patterns of hemorrhagic fever with renal syndrome in Chinese mainland, 2006–2025: a national surveillance analysis

Hemorrhagic fever with renal syndrome (HFRS) shows marked spatiotemporal heterogeneity and frequent zero counts in Chinese mainland. We analysed monthly HFRS surveillance data from 352 cities during 2006–2025 using a zero-inflated time-series model incorporating meteorological, e...

Establishing gender- and age-specific reference ranges for eight tumor markers in adults based on real-world data from Southern China

Abstract Objectives To establish and validate age- and sex-specific reference intervals (RIs) for eight common tumor markers using large-scale real-world data (RWD) and to compare the performance of five indirect statistical algorithms for RI derivation. Methods This retrospectiv...

Evaluation of acute FGF2 and PRDX3 for long COVID prediction across cohorts and proteomic platforms

Abstract Blood proteins measured during acute COVID-19 may help predict Long COVID, but models may fail when moved between cohorts and proteomic platforms. We fitted a reference model using age and sex (C0) in Su/INCOV and a protein model that also included FGF2 and PRDX3 (C2). T...

Differential diagnosis of ovarian growing teratoma syndrome and immature teratomas after chemotherapy based on CT imaging

Abstract Background To differentiate ovarian growing teratoma syndrome (OGTS) from immature teratoma (IMT) based on semantic CT imaging features and provide an adjunct imaging tool to support preoperative assessment and treatment planning. Materials and methods Patients with path...

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

Fraxetin Ameliorates Cognitive Impairment in STZ-Induced Mice: Involvement of Suppressed Microglial Hyperactivation and Improved Mitochondrial Dysfunction

Therapeutic for Alzheimer’s disease (AD) remains a pressing medical challenge in the field of neuroscience. Natural compounds with structural diversity and multi-target regulatory properties have attracted increasing attention for the treatment of complex neurodegenerative disord...

gutMDisorder v3.0: an updated database for dysbiosis of the gut and oral microbiota in phenotypes and interventions

Microbiota plays an essential role in host health, and dysbiosis of microbial communities has been widely associated with diverse phenotypes and intervention responses. With the rapid development of microbiome research, microbiome studies are no longer restricted to gut-derived s...

The impact of sleep quality on cognitive function in residents of high altitude areas: a cross-sectional study

This study aims to explore the current status of cognitive function among community residents in high-altitude areas, and analyze the influence of sleep quality on cognitive function, so as to provide a theoretical basis for developing intervention strategies to improve the cogni...

Evaluating the efficacy of pressure microcatheters for fractional flow reserve measurement in chronic thromboembolic pulmonary hypertension: a comparative study

This study aimed to compare the efficacy and procedural performance of pressure microcatheters and pressure guidewires for fractional flow reserve (FFR) measurement in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing balloon pulmonary angioplasty (BP...

Genotype and phenotypic spectrum of pycnodysostosis: report of a case harboring two novel CTSK variants and literature review

Abstract Background Pycnodysostosis is an extremely rare inherited skeletal dysplasia with incidence of about 1 to 1.7 per million neonates. We reported a patient with pycnodysostosis, who had typical craniofacial deformity, short stature and recurrent limb fracture history. Lite...

First-in-human phase Ia study of the covalent TEAD palmitoylation inhibitor BPI-460372 in patients with advanced solid tumors: pharmacokinetics, exposure-limited dosing, and early antitumor activity

The Hippo pathway is a critical regulator of tumor development and progression, dysregulation of the Hippo pathway drives tumorigenesis in multiple malignancies. BPI-460,372 is a first‑in‑class covalent irreversible inhibitor of transcriptional enhanced associated domain (TEAD) p...

Self-Adaptable Deep Eutectogels with High Stretchability, Low Hysteresis, and Long-Term Stability for Wearable Strain Sensors

Abstract Hydrogels are widely used in wearable flexible sensors, but suffer from dehydration, freezing, and bacterial growth under harsh environments. Here, we present a low-hysteresis eutectogel by incorporating quaternary ammonium chitosan (QCS) into an electrostatically driven...

Bioorthogonal Assembly of Cell-Nanoparticle Hybrids Enables Synergistic Cancer Therapy

Abstract Integrating nanoparticles (NPs) with living cells into a unified therapeutic system remains a major methodological challenge. Here, we describe a robust and modular bioorthogonal strategy for constructing cell-nanoparticle hybrids (CNHs) via sequential thiazolidine forma...

Smoking status and duration are associated with taxonomic and functional differences in the oral microbiome

Smoking is a major modifiable risk factor for human health and has been linked to alterations in the oral microbiome. However, how oral microbial composition and functional potential differ across smoking duration remains insufficiently characterized. This study aimed to evaluate...

Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens

Abstract Bats are hosts to diverse zoonotic viruses which can cause high case fatality rates in humans. Since detecting viruses in bats is difficult, antibodies are often used for surveillance, though their significance remains unclear in the absence of in vivo immunological stud...