Chinese Academy of Medical Sciences & Peking Union Medical College

Spatial distribution, clustering patterns, and economic burden of comorbidities among hospitalised pulmonary tuberculosis patients in Guangdong province: a spatial epidemiological study based on inpatient big data

Background: Comorbidities may complicate the treatment of pulmonary tuberculosis and exacerbate both the clinical and economic burden. We aimed to examine comorbidity patterns, spatial clustering, and economic burden in hospitalised pulmonary tuberculosis (PTB) patients in Guangd...

Diagnostic Predictive Model for Distinguishing Intravascular Large B-Cell Lymphoma Among Patients with Fever of Unknown Origin

Background/Objectives: Intravascular large B-cell lymphoma (IVLBCL) is a rare and diagnostically challenging disease, often presenting as fever of unknown origin (FUO). This study aimed to develop and validate diagnostic predictive models and scoring systems to distinguish IVLBCL...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Stratified meta-analysis of rodent diabetic neuropathy nerve transcriptomes identifies a down-regulated structural core

This record contains the derived data and analysis code for the study "Stratified meta-analysis of rodent diabetic neuropathy nerve transcriptomes identifies a down-regulated structural core" (manuscript submitted to Disease Models & Mechanisms, 2026). Twelve rodent (mouse and ra...

MOCR-DB: The Multi-Omics Causal Resource Database for Genetic Correlation, Causal Inference, and Functional Interpretation

Abstract Genome-wide association studies (GWAS) have revealed extensive polygenic signals and overlapping genetic architectures across human traits, creating a need for resources that connect trait-level genetic relationships with gene-level functional evidence. Here, we develope...

MIDAS: A multimodal interview-based framework for depression assessment from clinical interviews

Automated depression assessment from clinical interviews is a challenging intelligent healthcare task because depressive states are reflected not only in verbal responses, but also in acoustic and visual-behavioral cues. Existing multimodal methods have improved prediction perfor...

Novel insights of minocycline as a neurovascular protective agent in retinitis pigmentosa

Background/aims Retinitis pigmentosa (RP) is characterised by progressive photoreceptor degeneration accompanied by vascular abnormalities. We have previously demonstrated that minocycline exhibits therapeutic potential in RP. This trial aimed to evaluate its neurovascular protec...

Beyond Carbapenemases: Chromosomal Resistance Mechanisms and Carbapenemase Type Determine Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Carbapenem-Resistant Pseudomonas aeruginosa from China

Background: β-lactam/β-lactamase inhibitor combinations (BL/BLIs) and siderophore cephalosporin serve as critical polymyxin alternatives for carbapenem-resistant Pseudomonas aeruginosa (CRPA). However, systematic multicenter clinical data from China and the resistance mechanisms...

Comparative effectiveness of dietary supplements in dilated cardiomyopathy: a systematic review and network meta-analysis

Abstract Background Dilated cardiomyopathy (DCM) is a major cause of heart failure and cardiovascular mortality, partly due to impaired myocardial energy metabolism. Dietary supplements may offer benefits through improved mitochondrial function and antioxidant effects, and random...

Navigation‐Assisted Pure Endoscopic Transoral Styloidectomy for Recurrent Eagle Syndrome: A Pictorial Essay

ABSTRACT Background Complete resection of the styloid process at its skull‐base origin is challenging in recurrent Eagle syndrome because of postoperative fibrosis, distorted anatomy, and proximity to the internal carotid artery ( ICA ). Methods Bilateral dissections of two silic...

Multidimensional 5-hydroxymethylcytosine features in cell-free DNA enable the detection, staging and subtyping of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant cancer with limited biomarkers for early detection and disease stratification. Here, we investigated whether multidimensional 5-hydroxymethylcytosine (5hmC) features in plasma cell-free DNA (cfDNA) could support...

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

ABSTRACT Growth hormone–secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed RNA sequenc...

The optimal neoadjuvant modality in locally advanced gastric cancer in the era of immune-drugs: a multicenter retrospective analysis

Optimal neoadjuvant strategies for locally advanced gastric cancer (LAGC) remain contentious. The purpose of this study was to compare the survival prognosis and safety of LAGC receiving three different neoadjuvant modalities. In this multicenter retrospective cohort, 670 patient...

Association of Antibiotic Exposure with Survival Outcomes in Patients with Advanced KRAS-Mutated NSCLC Receiving Immune Checkpoint Inhibitors

Background: Antibiotic exposure has been associated with reduced benefit from immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC). However, evidence in patients with KRAS-mutated NSCLC remains limited. This study evaluated the associations of a...

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Spliceosome gene mutations synergize with anthracyclines to amplify atrial fibrillation risk in hematologic malignancies: a multicenter cohort study with discovery and validation

Abstract Background Atrial fibrillation (AF) is a life‑threatening complication in patients with hematologic malignancies, yet personalized risk stratification remains challenging. Spliceosome gene mutations are key drivers of these malignancies, but their specific role in AF pat...

Case report on new injection method for treating female Meige syndrome patients

Meige syndrome is an uncommon, long-lasting, and recurring form of craniofacial focal dystonia marked by bilateral blepharospasm and involuntary facial muscle contractions that greatly disrupt the daily activities and social interactions of those affected. The primary minimally i...

CX3CR1⁺ CD8⁺ cytotoxic T cells drive tumor killing in esophageal squamous cell carcinoma during neoadjuvant therapy

Immune checkpoint inhibitor (ICI) responses in esophageal squamous cell carcinoma (ESCC) are highly variable, and the immune mechanisms underlying therapeutic sensitivity remain unclear. Here we show, using single-cell RNA, T-cell receptor and whole-exome sequencing of 52 ESCC pa...

ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility

Fatty Acid Oxidation (FAO) dysfunction induces pro-fibrotic transition in tubular epithelial cells (TECs) and contributes to renal fibrosis in chronic kidney disease (CKD); however, the drivers of metabolic reprogramming in TECs remain unclear. We investigate the role of aldehyde...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...