Chinese Academy of Medical Sciences & Peking Union Medical College

Diabetic plaque calcification: mechanisms, imaging phenotypes, and clinical implications

Diabetes is associated with a higher burden and heterogeneous phenotypes of plaque calcification, which may influence plaque stability and cardiovascular risk. This review examines diabetic plaque calcification as a dynamic process driven by hyperglycemia and other metabolic dist...

Evaluation of the antibacterial activity of turkish gall extract against Staphylococcus aureus ATCC 6538

Abstract Background Staphylococcus aureus is a common foodborne pathogen and a frequent cause of clinical infections. It forms dense biofilms by adhering to surfaces of objects or the human body, thereby reducing the bactericidal efficacy of antibiotics and disinfectants. This st...

Development and validation of an interpretable machine learning model for predicting ICU prognosis in critically ill patients with invasive pulmonary aspergillosis: a multicenter study

Invasive pulmonary aspergillosis (IPA) is associated with elevated mortality among intensive care unit (ICU) patients. Early prognostic risk stratification is of great importance; however, validated clinical tools remain limited. This study aimed to develop and validate an interp...

VEXAS Syndrome：Report of One Case.

This article details the diagnosis and treatment of an elderly male patient with VEXAS syndrome who came with fatigue and fever.The patient thereafter developed several clinical manifestations，including macrocytic anemia，tracheal and bronchial wall thickening，polyarthritis，ra...

Analysis and Model Prediction of the Burden of Early-Onset Cancer Attributed to Overweight and Obesity in the Chinese Population From 1990 to 2021.

<0.001）.The age group of 30-34 years old in 2021 compared with 1990 saw the most significant increases （88.24% and 91.02%，respectively） in cancer mortality and DALY rates due to overweight and obesity.It was predicted that in the next 15 years，the age-standardized DALY rates...

Construction and Antitumor Efficacy of an Antigen-Adjuvant Self-Carrier Spherical Peptide Nanovaccine.

central memory T cells.After antigen restimulation，the secretion levels of tumor necrosis factor-α and interferon-γ were significantly elevated，which indicated long-lasting immune memory. Conclusions A carrier-free spherical peptide nanovaccine based on the co-delivery strategy...

Ultrasound-Guided Peripheral Nerve Pulsed Radiofrequency Combined With Platelet-Rich Plasma Injection for Complex Regional Pain Syndrome：Report of One Case.

Complex regional pain syndrome is a refractory disease characterized by complex pathogenesis，severe chronic pain，and autonomic nervous system dysfunction.This article reports a 26-year-old female patient who presented with severe，electric shock-like pain and hyperalgesia in th...

Progress in Molecular Biological Mechanism of Endometrial Cancer Induced by Obesity.

Obesity is recognized as a major risk factor for endometrial cancer，and its tumor-promoting mechanisms have drawn increasing attention in recent years.Current evidence highlights that obesity drives the initiation and progression of endometrial cancer through three core pathways...

Ultrasound-Guided Lumbar Puncture：Experience in Two Difficult Cases.

Lumbar puncture is an important clinical technique.In patients with spinal deformities or those who undergo lumbar surgery，using surface anatomical landmarks for localization is often challenging，and real-time ultrasound guidance can be employed to complete the procedure.This a...

Comparative chloroplast genomics of 75 Asparagus species reveals conserved genome architecture, gene-specific positive selection, and chloroplast–nuclear phylogenetic discordance

The chloroplast genome offers a compact, maternally inherited resource for resolving evolutionary relationships in plants, yet in Asparagus it has received limited genus-wide attention relative to recent nuclear genomic efforts. Here, we de novo assembled 35 chloroplast genomes:...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

Local vs systemic inflammation and outcomes after percutaneous coronary intervention

BACKGROUND AND AIMS: Inflammation influences outcomes after percutaneous coronary intervention (PCI) in coronary artery disease (CAD). This study aimed to evaluate the relative and combined prognostic value of local coronary inflammation, and systemic inflammation for adverse out...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

MIDAS: A multimodal interview-based framework for depression assessment from clinical interviews

Automated depression assessment from clinical interviews is a challenging intelligent healthcare task because depressive states are reflected not only in verbal responses, but also in acoustic and visual-behavioral cues. Existing multimodal methods have improved prediction perfor...

Spatial distribution, clustering patterns, and economic burden of comorbidities among hospitalised pulmonary tuberculosis patients in Guangdong province: a spatial epidemiological study based on inpatient big data

Background: Comorbidities may complicate the treatment of pulmonary tuberculosis and exacerbate both the clinical and economic burden. We aimed to examine comorbidity patterns, spatial clustering, and economic burden in hospitalised pulmonary tuberculosis (PTB) patients in Guangd...

2026 Chinese expert consensus on perioperative management for left ventricular assist device implantation in adults

Abstract Purpose This consensus was developed to address the lack of standardized perioperative management protocols for left ventricular assist device (LVAD) implantation in China and to build on recently published national consensus documents addressing preoperative and postope...

Novel insights of minocycline as a neurovascular protective agent in retinitis pigmentosa

Background/aims Retinitis pigmentosa (RP) is characterised by progressive photoreceptor degeneration accompanied by vascular abnormalities. We have previously demonstrated that minocycline exhibits therapeutic potential in RP. This trial aimed to evaluate its neurovascular protec...

Integrated multiomics reveals a clinically relevant CXCL8-centric protein network in pediatric postinfectious bronchiolitis obliterans

Pediatric postinfectious bronchiolitis obliterans (PIBO) is a long-term sequela of severe lower respiratory tract infection. However, the underlying pathogenic mechanisms within the airways remain poorly understood. Bronchoalveolar lavage fluid (BALF) from six children with PIBO...

Diagnostic Predictive Model for Distinguishing Intravascular Large B-Cell Lymphoma Among Patients with Fever of Unknown Origin

Background/Objectives: Intravascular large B-cell lymphoma (IVLBCL) is a rare and diagnostically challenging disease, often presenting as fever of unknown origin (FUO). This study aimed to develop and validate diagnostic predictive models and scoring systems to distinguish IVLBCL...

Risk factors for sudden cardiac death in heart failure

Background: Heart failure (HF) is a global health burden with high mortality. Sudden cardiac death (SCD) remains a major complication, highlighting the need for accurate risk prediction. Methods: We conducted a systematic review and meta-analysis, guided by the Population, Interv...