Chinese Academy of Medical Sciences & Peking Union Medical College

Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections

Abstract The accurate discrimination of bacterial infections from sterile inflammation is a critical yet unresolved challenge in clinical diagnostics. To address this, we designed and synthesized a series of 68Ga-labeled PET tracers derived from the FDA-approved iron chelator, de...

The ventilation–perfusion differential index assists target lobe selection and improves V/Q redistribution for endobronchial valve lung volume reduction: a prospective study

Identifying the optimal target lobe remains a challenge for bronchoscopic lung volume reduction (BLVR) with endobronchial valves (EBVs). The ventilation/perfusion differential index (VQDI) has been identified as a possible tool for target lobe selection in BLVR. Twenty-four indiv...

Calcium Hydroxylapatite in Facial Rejuvenation: A Review from Multi-Layered Aging Mechanisms to Material-Property-Guided Clinical Practice

Contemporary research on facial aging is undergoing a profound paradigm shift, transitioning from macroscopic descriptive phenotyping to refined cellular-molecular mechanistic dissection. This review reveals these frontiers across multi-omics and structural dimensions, highlighti...

Urine metabolomics reveals key pathways supporting neuronal regeneration and consciousness recovery in disorders of consciousness

Disorders of consciousness (DoC) are debilitating conditions resulting from severe brain injury, requiring not only structural preservation but also active neuronal regeneration for recovery. These regenerative processes are metabolically demanding and can be tracked through syst...

Accumulation patterns of bioactive components in Morinda officinalis How across growth years

Harvesting time is a crucial factor affecting the quality of traditional Chinese medicine. Morinda officinalis How is a perennial herb with its root frequently used in both medicine and food industries. Iridoids, anthraquinones and saccharides are the main bioactive components of...

Sprayable EGCG-Grafted Alginate Hydrogels Embedded with Platelet Exosomes: Functional Synergy of Immunomodulation and Angiogenesis for Accelerating Burn Wound Healing

Abstract Burn wounds were often entrapped in inflammatory cascades and highly vulnerable to bacterial infection. Meanwhile, accumulated necrotic tissue and impaired vessels further aggravated local ischemia, thereby impeding the wound healing process. Herein, a sprayable hydrogel...

Causal inference maps the sex-dimorphic genetic architecture and inflammatory-metabolic networks underpinning perceived aging in UK Biobank

Self-perceived facial aging is an externally observable aging-related phenotype that may reflect both biological and psychosocial dimensions of aging. However, its genetic and molecular determinants, sex-specific heterogeneity, and relationship with systemic aging-related pathway...

Calcium dysregulation in synergy with sonodynamic therapy via medroxyprogesterone-targeted and ROS-responsive nanoparticles for endometrial cancer

Effective therapies that enable precise drug delivery and integrated monitoring are urgently needed for fertility-sparing management of endometrial cancer (EC). Although calcium channel blockers (CCBs) exhibit anti-proliferative potential in EC, their poor tumor selectivity and s...

A Second-Order Product-Type Implicit-Explicit Runge-Kutta Method Preserving Unit Length and Energy Dissipation Structures for Gradient Flows of Vector Fields

Abstract. Gradient flows of unit vector fields arise in a wide range of physical models such as harmonic map heat flows, nematic liquid crystals, and magnetization dynamics. Designing numerical schemes that simultaneously preserve the unit length constraint and dissipate energy i...

Knowledge and attitudes of nurses and nursing students about Alzheimer’s disease: a systematic review and meta-analysis

With the global aging population, the burden of Alzheimer’s disease (AD) is increasing, underscoring the critical need for competent AD care. While previous studies have explored nursing personnel’s knowledge of and attitudes toward AD, a comprehensive synthesis across diverse cu...

Trends in mortality attributable to complications of medical and surgical care among cancer patients

BACKGROUND: Complications of medical and surgical care (CMSC) are unintentional harms from medical interventions. Their mortality burden among cancer patients remains understudied. We examined trends and disparities in CMSC-attributable mortality among U.S. cancer patients over t...

Endoperoxides Show Distinct Reactivity toward Heme and Hemoglobin

Abstract Artemisinin and Yingzhaosu A (YZSA), two endoperoxide-containing natural products with antimalarial activity discovered through China’s historic 523 Project, have long been the focus of global antimalarial research. Many scientific studies have proposed that their endope...

Numerical Ergodicity and Optimal Strong Error Estimates for a Class of Novel Tamed Schemes to Superlinear SPDEs

We construct a class of novel tamed schemes for superlinear stochastic partial differential equations (SPDEs), including the stochastic Allen–Cahn equation driven by either multiplicative or additive noise. The schemes preserve the same Lyapunov structure as the original system,...

Research Trends in Frailty and Delirium in Older Adults: A Bibliometric Analysis

Background/Objectives: Frailty and delirium represent critical geriatric syndromes with profound implications for older adults’ health outcomes. This study aimed to quantitatively map global research trends and thematic developments in frailty and delirium among older adults thro...

Outcomes and computational analysis of visceral branches in thoracoabdominal aortic aneurysm endovascular repair: a single-center study

To report the clinical outcomes of endovascular repair for thoracoabdominal aortic aneurysms (TAAA) and to investigate the hemodynamic mechanisms underlying post-operative visceral artery complications using computational fluid dynamics (CFD). A retrospective analysis was conduct...

A novel PRPF31 variant associated with autosomal dominant retinitis pigmentosa in Japanese families

BACKGROUND: PRPF31-associated inherited retinal dystrophy is an autosomal dominant form of retinitis pigmentosa (RP), typically caused by haploinsufficiency. Although affected individuals generally exhibit early-onset nyctalopia and progressive visual field loss, the clinical and...

From glucolipotoxicity to cardiorenal injury: mitophagy imbalance in the cardiovascular–kidney–metabolic syndrome continuum

Cardiovascular–kidney–metabolic (CKM) syndrome is a progressive systemic disease driven by the interplay among metabolic abnormalities, chronic kidney disease, and cardiovascular disease. It is characterised by a high prevalence, complex pathophysiological mechanisms, and extensi...

Case report of neoadjuvant treatment with sugemalimab combined with platinum-based doublet chemotherapy in stage IIIB lung squamous cell carcinoma and research in potential biomarkers

Here we present a case of stage IIIB (cT3N2M0) lung squamous cell carcinoma, who was potentially resectable, and underwent a complete resection after three cycles of neoadjuvant therapy induced by sugemalimab combined with platinum-based doublet chemotherapy. The assessment of re...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Age-related changes of FCGR3A+ natural killer cells and their association with elderly atopic dermatitis

Background The increasing global ageing population has led to a rising prevalence of elderly atopic dermatitis (eAD). Natural killer (NK) cells play an important role in skin homoeostasis; however, their involvement in eAD remains unclear. This study investigates the functional r...