Chinese Academy of Medical Sciences & Peking Union Medical College

Metabolic and vascular stress drive progression of erectile dysfunction in a rat model

Erectile dysfunction (ED) is a common male sexual disorder, with the vasculogenic subtype primarily driven by endothelial injury and metabolic dysfunction. Current research often lacks a systematic, time-course analysis of its progressive pathology. We performed a 16-week time-co...

The membrane skeleton density of red blood cells in MYH9 -related disease patients is decreased

MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9 gene, which encodes the heavy chain of nonmuscle myosin IIA. Nearly all MYH9-RD patients present with macrothrombocytopenia, characterized by decreased platelet count and increased pl...

Development of a symptom cluster scale for breast cancer patients undergoing adjuvant chemotherapy based on the Chinese population: a Delphi-based study

Breast cancer is the most common malignancy among women in China.Postoperative adjuvant chemotherapy can reduce the risk of recurrence, but it can also give rise to complex symptom clusters that significantly affect patients’ quality of life and treatment adherence. Currently, sp...

Prognostic significance of positive peritoneal cytology in early-stage endometrial carcinoma after postoperative radiotherapy: a single-center retrospective cohort study

The prognostic significance of positive peritoneal cytology (PPC) in early-stage endometrial carcinoma (EC) remains controversial, particularly in the setting of contemporary adjuvant treatment. We aimed to evaluate the association of PPC with survival outcomes and recurrence pat...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Residual lipid-related proteomic and metabolomic signatures associated with major adverse cardiovascular events after revascularization in peripheral artery disease

Patients with peripheral artery disease (PAD) remain at high risk for major adverse cardiovascular events (MACE) after lower-extremity revascularization. In contemporary practice, widespread lipid-lowering therapy may reduce the discriminatory value of conventional lipid paramete...

Oral to Nasal Endotracheal Tube Exchange in a Difficult Airway Patient During Maxillofacial Surgery

This case report describes a successful oral-to-nasal endotracheal tube exchange using a combined video laryngoscopy and fiberoptic bronchoscopy (FOB) technique in a 48-year-old patient with Crouzon syndrome following modified Le Fort III osteotomy and Le Fort I osteotomy. Severe...

Multicenter evaluation of Coyote FlashDetect LyocartE multiplex assays for six respiratory pathogens: a comparative analysis with Sansure and Cepheid assays

ABSTRACT Respiratory diseases caused by common respiratory pathogens, such as influenza A/B (Flu A/B), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumoniae (MP), share many of the same symptom...

Verrucous porokeratosis with prominent follicular involvement

The authors declare no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Charting the Phenotypic Landscape of FBN1 Variants in Marfan Syndrome With Ectopia Lentis Through Extreme Phenotype Sampling

Purpose: Phenotypic heterogeneity is a hallmark of Marfan syndrome (MFS) with ectopia lentis (EL), yet genotype-phenotype correlations for ocular traits remain incompletely understood. This study aimed to identify genomic determinants of extreme ocular phenotypes using a combined...

The Lactate–Lactylation Axis as a Metabolic–Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma

Therapeutic failure in esophageal squamous cell carcinoma (ESCC) can arise as tumor cells and their microenvironment adapt to sustained treatment pressure. The lactate–lactylation axis may connect altered metabolism with adaptive treatment responses through changes in protein and...

Preoperative CT-Derived Stone Burden Metrics for Predicting Stone-Free Status and Operative Time After Retrograde Intrarenal Surgery

Objectives: Non-contrast computed tomography (NCCT) is used before retrograde intrarenal surgery (RIRS) to describe stone size, location, and complexity, but the best way to summarize stone burden remains unsettled. Therefore, we compared multidimensional NCCT-derived burden metr...

Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) of unclear etiology. Dupilumab, a humanized monoclonal antibody binding to interleukin-4 receptor alpha (IL-4Rα), suppresses both IL-4 and IL-13 signaling pathways. However, the therapeu...

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by excessive accumulation of β-amyloid (Aβ) peptides in the brain. Beta-secretase 1 (BACE1), the rate-limiting enzyme in the amyloidogenic processing pathway of amyloid precursor protein (A...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Molecular-level observation of the self-assembly of a virus-like particle

Abstract Biomolecular assembly is a cornerstone of cellular organization. Revealing its underlying principles is essential for understanding biological function 1,2 and malfunction in disease 3,4 . Viral capsid assembly is the archetypal self-assembly system 5–7 , which has been...

Automatic segmentation of malignant pulmonary nodules on LUNA16 subsets using an attention-guided 3D U-Net framework

Objective Lung cancer is the leading cause of cancer-related mortality worldwide, and accurate segmentation of malignant pulmonary nodules is essential for quantitative lesion analysis and computer-aided lung cancer screening. Manual segmentation is time-consuming and highly depe...

Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses

Abstract Coronaviruses circulating in wildlife, such as European and Asian hedgehog merbecoviruses (EriCoVs), pose a potential transmission risk. Knowledge of viral receptors can inform risk assessment and development of countermeasures; however, the functional receptor for EriCo...

Beyond Recanalization: Neurovascular Unit Protection and Precision Adjunctive Therapy for Ischemic Stroke in the Reperfusion Era

Intravenous thrombolysis and endovascular thrombectomy (EVT) have increased large-vessel recanalization in acute ischemic stroke, yet macrovascular reopening does not ensure tissue reperfusion or functional recovery. Microvascular no-reflow, blood–brain barrier failure, oxidative...