Chinese Academy of Medical Sciences & Peking Union Medical College

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Non-apnea electrical impedance tomography for bedside ventilation–perfusion assessment during spontaneous breathing: a prospective cross-over validation study

Conventional saline-contrast electrical impedance tomography (EIT) perfusion imaging typically requires a brief end-expiratory apnea during saline injection to reduce respiratory interference. However, this maneuver is often difficult or impractical in spontaneously breathing pat...

Closing the cervical screening cascade gap toward WHO 90-70-90 elimination targets: A systematic review and meta-analysis of 25 studies in 11 countries

The WHO 90-70-90 cervical cancer elimination targets require that 90% of women with screen-detected lesions receive appropriate treatment by 2030. Achieving this target depends on closing cascade gaps from screen-positive to diagnostic resolution. Whether intervention effectivene...

Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study

Abstract Objective The role of geometric-morphological parameters derived from cardiac magnetic resonance imaging (CMR) in assessing and stratifying chronic pulmonary thromboembolism (CPTE) remains unclear. Material and methods We prospectively enrolled 53 CPTE patients (16 with...

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse chemical structures and broad biological activities. However, their clinical application is often limited by poor aqueous solubility, low membrane permeability,...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

Delayed mechanical mitral prosthetic leaflet detachment with distal embolization and conservative management: a case report

Mechanical prosthetic valve leaflet detachment is an exceedingly rare but potentially fatal complication of valve replacement surgery, typically presenting with acute severe regurgitation and hemodynamic collapse. The underlying mechanisms remain incompletely understood, and mana...

External validation of AI assisted colposcopy using WHO dataset for cervical precancer and cancer detection

Artificial intelligence (AI)-guided colposcopy has previously been developed to assist colposcopists in detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and guiding biopsies, but internal testing of the AI model could overestimate diagnostic performance. We v...

Dynamic fate of beige adipocytes in fat grafting and inflammatory regulation

Autologous fat grafting is widely used in reconstructive and cosmetic surgery, but its success is limited by unpredictable graft survival. Recent studies have found that white adipocytes within fat grafts can transform into beige adipocytes—a process called browning—yet whether t...

Associations of psoriasis history with general discrimination‐related experiences in US adults

The data underlying this article are publicly available from IPUMS Health Surveys and the National Center for Health Statistics 2023 National Health Interview Survey.

A novel JAG1 variant causing familial Alagille syndrome

Alagille syndrome (ALGS) is a rare autosomal dominant multisystem disorder typically caused by pathogenic variants in JAG1 and NOTCH2, accompanied with a wide range of clinical variability. Currently, new pathogenic variants in JAG1 and NOTCH2 have been continuously reported. Exo...

Post-traumatic stress disorder and anorexia nervosa in a patient with chronic arsenic poisoning: a case report and review of literature

We presented the case of a 33-year-old female referring to the ward of gastroenterology for progressive diarrhea, darkening of skin, edema, and numbness in bilateral lower limbs. She had a history of a persistent self-administration of bisacodine and Chinese medicine (Bezoar Anti...

AAV.IVT18-mediated RDH12 gene therapy restores retinal metabolism in Rdh12 knockout rats and patient-derived iPSC-retinal organoids

Biallelic variants in retinol dehydrogenase 12 ( RDH12 ) cause severe inherited retinal diseases (IRDs) with no available treatments. Given the potential risks of subretinal delivery in patients with macular atrophy, we evaluated intravitreal AAV-mediated RDH12 gene augmentation....

Whole-genome sequencing investigation of a neonatal intensive care unit outbreak involving colonization and infection Klebsiella grimontii ST566 and Klebsiella michiganensis ST35

The Klebsiella oxytoca complex (KoC) comprises opportunistic pathogens capable of causing outbreaks in neonatal intensive care units (NICUs). We investigated a NICU KoC outbreak involving colonized and infected preterm infant in the NICU of a Chinese tertiary hospital to characte...

A Novel Suture-Based Otoplasty Technique Combining Figure-of-Eight and Mattress Sutures for Prominent Ear Correction: A Retrospective Study of 89 Patients

BACKGROUND: Prominent ear is a common congenital deformity that can cause significant aesthetic and psychosocial concerns. This study introduces a novel suture-based otoplasty technique that combines figure-of-eight and mattress sutures to achieve natural-appearance aesthetic out...

Cerebellar Glutamate Chemical Exchange Saturation Transfer Alterations Correlated With Cognitive Impairment in Parkinson's Disease

ABSTRACT The role of cerebellar glutamatergic dysfunction in cognitive impairment of Parkinson's disease (PD) remains poorly understood. Glutamate chemical exchange saturation transfer (GluCEST) imaging enables noninvasive assessment of regional glutamate levels. To investigate t...

β-Blockers, anxiety, and sleep: an analysis of interactions in early sleep disorders following percutaneous complete revascularization

To investigate the factors influencing sleep quality in the early postoperative period following complete revascularization, focusing on the interaction between anxiety levels and β-blocker use, and to examine whether this interaction is moderated by variables such as insulin res...

Development and Validation of a Plastic Surgery-Oriented Anatomical Scoring System for Surgical Indications in Vulvar Lichen Sclerosus

BACKGROUND: Vulvar lichen sclerosus is a chronic inflammatory condition that often leads to progressive anatomical distortion and functional impairment. For patients with advanced-stage disease, surgical intervention becomes a treatment option. However, a standardized tool to gui...

Development of a symptom cluster scale for breast cancer patients undergoing adjuvant chemotherapy based on the Chinese population: a Delphi-based study

Breast cancer is the most common malignancy among women in China.Postoperative adjuvant chemotherapy can reduce the risk of recurrence, but it can also give rise to complex symptom clusters that significantly affect patients’ quality of life and treatment adherence. Currently, sp...

Modulation of the gut–liver axis via TMAO metabolism by Ramulus Mori alkaloids alleviates diabetic atherosclerosis

Diabetic atherosclerosis is a complex condition driven by intertwined metabolic disturbances including hyperglycemia, dyslipidemia, inflammation, and oxidative stress. The gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has emerged as a key contributor that links...