Chinese Academy of Medical Sciences & Peking Union Medical College

A comparison of perioperative outcomes for da Vinci robotic-assisted, laparoscopic and open surgery in oncologic procedures: a systematic literature review and meta-analysis of evidence from China

The use of robot-assisted surgery (RAS) has increased markedly in China, but comparative evidence on its perioperative performance in cancer care is dispersed across specialties and study designs. This review synthesized Chinese evidence to examine the safety and effectiveness of...

Intensive vs Standard Blood Pressure Lowering in People With and Without Chronic Kidney Disease

Importance There is uncertainty about the effects of intensive blood pressure (BP) lowering on risks of cardiovascular disease and kidney failure in patients with chronic kidney disease (CKD). Objective To assess the standardized effects of intensive BP lowering on cardiovascular...

AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial

Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s dise...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Risk factors of anterior capsular contraction syndrome in Marfan syndrome after intraocular lens and modified capsular tension ring implantation

Purpose To identify risk factors for anterior capsular contraction syndrome (ACCS) after in-the-bag intraocular lens (IOL) implantation in patients with Marfan syndrome (MFS) and ectopia lentis (EL). Methods This study included patients diagnosed with MFS and EL, who underwent in...

Smoking status and duration are associated with taxonomic and functional differences in the oral microbiome

Smoking is a major modifiable risk factor for human health and has been linked to alterations in the oral microbiome. However, how oral microbial composition and functional potential differ across smoking duration remains insufficiently characterized. This study aimed to evaluate...

Affibody-based approaches as potential therapeutics for breast cancer: mechanisms, applications, and future perspectives

Breast cancer presents a significant therapeutic challenge due to the substantial molecular and genetic diversity among its subtypes, thereby necessitating the development of refined intervention strategies. Macromolecular therapies, such as monoclonal antibodies, are often hinde...

Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens

Abstract Bats are hosts to diverse zoonotic viruses which can cause high case fatality rates in humans. Since detecting viruses in bats is difficult, antibodies are often used for surveillance, though their significance remains unclear in the absence of in vivo immunological stud...

The Oxidized Phospholipid PGPC Impairs Angiogenesis by Inhibiting Endothelial Autophagosomal–Lysosomal Fusion Through NPC1-Induced Syntaxin 17 Acetylation and Ubiquitination

BACKGROUND: Angiogenesis is essential for the recovery of ischemic hearts with coronary artery disease (CAD). PGPC (1-palmitoyl-2-glutamyl-sn-glycero-3-phosphocholine) is a major phospholipid oxidation product in atherosclerotic lesions. Autophagy participates in angiogenesis. Ho...

Phase separation of PHLDB2 promotes lung adenocarcinoma progression through FLNA stabilization and ERK activation

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, but the phase separation-related mechanisms that support its progression remain poorly defined. By integrating phase separation-related gene profiling with prognostic modeling, we identified PHLDB2...

Association between intraoperative 20% albumin administration and perioperative RBC transfusion in total arch replacement: a single-center retrospective cohort study

Intraoperative albumin administration has been associated with increased bleeding and transfusion in on-pump cardiac surgery. However, albumin may also protect the endothelial glycocalyx and modulate inflammation during prolonged cardiopulmonary bypass (CPB) and deep hypothermic...

Prostate cancer burden and attributable risk factors in East Asia from 1990 to 2021: a systematic analysis

Prostate cancer is a significant health concern in East Asia, where distinctive characteristics of disease presentation and outcomes warrant focused epidemiological investigation. This study evaluated the current status, future trends and risk factors across six East Asian region...

Activatable Nanovesicle Rewires Immunometabolic Barriers for NIR-II Photoacoustic-Guided Sono-immunotherapy of Glioblastoma

Abstract Glioblastoma (GBM) remains largely refractory to immunotherapy owing to a restrictive brain tumor niche that limits therapeutic access and fosters persistent immune evasion. Here, we present a programmed nanovesicle to sequentially overcome biological barriers and rewire...

Lactate suppresses T follicular helper cells in lupus in association with metabolic-epigenetic reprogramming

Aberrant CD4⁺ T cell differentiation, particularly the expansion of T follicular helper (Tfh) cells, is a hallmark of systemic lupus erythematosus (SLE) and is critically dependent on metabolic reprogramming. Although altered lactate metabolism has been implicated in autoimmune d...

Clinical Utility of Drug-Eluting Beads Bronchial Arterial Chemoembolization in Advanced Refractory Non-Small Cell Lung Cancer

Objective: This study mainly focused on evaluating the efficacy and safety of drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) in treating advanced refractory non-small cell lung cancer (NSCLC) patients, with an exploratory investigation of whether combining DEB...

Air pollution and early-onset lung cancer: from environmental carcinogenesis to early intervention strategies.

Air pollution remains a global public health challenge, with nearly the global population (99%) breathing air that exceeds World Health Organization (WHO) guideline limits-annual means of 5 μg/m3 for PM2.5 and 15 μg/m3 for PM10. Both household and ambient air pollution are classi...

Anesthetic management for pulsed field ablation in a patient with Eisenmenger syndrome using general anesthesia with spontaneous ventilation: a case report

Abstract Background Drug-refractory atrial tachyarrhythmia is an important precipitating factor for recurrent heart failure decompensation in patients with Eisenmenger syndrome (ES). Although percutaneous pulsed field ablation (PFA) represents a potential therapeutic option for a...

Cardiometabolic medicine in China: Burden, challenges, and strategic priorities

The development of cardiometabolic medicine (CMM) reflects a shift in cardiovascular disease (CVD) management from organ-based care toward greater cross-system integration. CMM integrates cardiovascular, endocrine, renal, and public health domains to address the bidirectional int...

Stakeholder Perspectives on Barriers and Facilitators to Implementing Nurse‐Led Diabetic Plantar Pressure Assessment and Management: A Multicentre Group Concept Mapping Study

ABSTRACT Aim To comprehensively identify, conceptualize and map the barriers and facilitators influencing the implementation of nurse‐led diabetic plantar pressure assessment and management (NL‐DPPAM) from a multicentre, multi‐stakeholder perspective and to construct a priority a...

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

ABSTRACT Severe muscle fat infiltration is a contributing factor to muscle loss, particularly in the spinal sarcopenia population. However, the underlying mechanism largely remains elusive. Here, we identified the intramuscular fat fraction (IMFF), rather than perimuscular fat fr...