Chinese Academy of Medical Sciences & Peking Union Medical College

H2S gas-actuated microrobots with clawed geometry for radiation enteritis protection by regulating neuro-immune axis

Radiation enteritis represents a critical complication associated with pelvic or abdominal radiotherapy, yet clinically available drugs show limited efficacy and significant side effects. The excessive reactive oxygen species induced by radiation and dysregulated inflammatory cas...

Frailty-Related Metabolic Signature in the Association Between Frailty and Coronary Artery Disease: Modification by Genetic Susceptibility

Background Frailty is associated with increased coronary artery disease (CAD) risk, but the circulating metabolic features underlying the frailty–CAD relationship and their interplay with genetic susceptibility remain unclear. This study aimed to identify a frailty-related metabo...

Liquid biopsy, cfDNA, and machine learning: an integrative approach to cardiovascular diseases

Cardiovascular diseases (CVDs) and their complications remain the leading cause of mortality worldwide. However, obtaining diseased cardiovascular tissue is often invasive, costly, and clinically impractical, highlighting the need for noninvasive approaches that can capture dynam...

Dynamic cardio-renal-metabolic trajectories identify sepsis subphenotypes for individualized management: a cross-population cohort study

Sepsis heterogeneity remains a major barrier to precision medicine. Although cardio-renal-metabolic interactions critically influence outcomes, their dynamic evolution is rarely integrated into clinical phenotyping. We aimed to identify distinct sepsis subphenotypes based on dyna...

A dual-tower multimodal framework with feature quality enhancement for predicting pathological complete response after neoadjuvant chemotherapy in breast cancer: a multicenter study

BACKGROUND: Pathological complete response (pCR) is a key endpoint following neoadjuvant chemotherapy (NAC) in breast cancer, with potential to guide treatment adaptation and surgical de-escalation. However, limited generalizability across institutions remains a major challenge d...

ESAT-6 and CFP-10 in tuberculosis: bridging virulence to diagnostic applications

Tuberculosis (TB) remains a major global public health challenge. Accurate detection of Mycobacterium tuberculosis ( Mtb ) infection, particularly latent tuberculosis infection (LTBI), is essential for targeted preventive treatment and progress toward TB elimination. The traditio...

EXPRESS: Association between Neurovascular Network Dysfunction and Poor Sleep Quality in Patients with Cerebral Small Vessel Disease

BACKGROUND/HYPOTHESIS: Poor sleep quality is frequently reported among patients with cerebral small vessel disease (CSVD), but its neurovascular correlates remain unclear. We examined exploratory associations between multidomain neurovascular network (NVN) measures and poor sleep...

Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect

Abstract With the increasing rates of cesarean section (CS), cesarean section scar defect (CSD) has become an escalating clinical concern due to uterine dysfunction and reduced fertility. However, the biological basis of CSD remains poorly understood, particularly the mechanisms...

Enhancing FAIR data practices in China: An integrated strategy for biomedical research

The construction of scientific data compliant with FAIR (Findability, Accessibility, Interoperability, and Reusability) principles has become a consensus in the biomedical field. However, FAIR is often implemented at the data submission stage, leading to suboptimal outcomes, such...

Diagnostic Performance of Donor‐derived Cell‐free DNA Combined With Immune Activation Markers for Detecting Acute Rejection After Liver Transplantation

BACKGROUND: Accurate differentiation of acute rejection (AR) from other causes of graft dysfunction after liver transplantation remains challenging in real-world clinical practice. Although donor-derived cell-free DNA (dd-cfDNA) has emerged as a promising non-invasive biomarker o...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Blastocyst Diameter and Collapse as Predictors of Live Birth Following Single Blastocyst Transfer: A Time-Lapse Morphometric Analysis.

OBJECTIVE: To investigate whether blastocyst diameter measured immediately prior to transfer and the occurrence of blastocyst collapse predict live birth outcomes after single blastocyst transfer (SBT). METHODS: This retrospective cohort study included 476 patients undergoing the...

DNA Barcoding for Identification and Traceability in the Entire Industrial Chain of Lonicerae Japonicae Flos

As a traditional medicinal plant in China, Lonicerae Japonicae Flos (LJF) is extensively used in traditional Chinese medicine and Medicine Food Homology products, supporting a well-established industrial chain with diverse applications. However, the entire industrial chain is per...

Explainable machine learning model based on cardiac CT angiography for predicting functional improvement after atrial fibrillation ablation: a multicenter study

Radiofrequency ablation is an established therapy for atrial fibrillation (AF), but outcomes are heterogeneous in patients with concomitant heart failure (HF). Therefore, we aimed to develop an explainable machine learning (ML) model based on cardiac CT angiography (CTA) for pred...

MultiRankDTA: A Hybrid Ranking Framework for Robust and Generalizable Drug-Target Affinity Prediction

Abstract Predicting drug-target affinity (DTA) is essential for screening candidate compounds in early-stage drug discovery. However, most existing computational methods formulate DTA prediction as a regression task, leading to an objective mismatch with the practical need to ran...

High prevalence and immunophenotypic diversity of clonal T‑large granular lymphocytes in JAK2‑mutated myeloproliferative neoplasms

Patients with JAK2‑mutated MPN may develop clonal T‑cell expansions, but the prevalence, immunophenotypic spectrum, and association with other lymphoid clones remain poorly defined. Clonal T‑large granular lymphocyte (T‑LGL) expansions have been observed in myeloproliferative neo...

Uterine corpus volume changes during definitive chemoradiotherapy for cervical cancer in pregnancy

Cervical cancer in pregnancy (CCIP) is rare, and evidence on definitive (chemo)radiotherapy is limited. Within our institutional CCIP cohort, we focused on the subset who received definitive concurrent chemoradiotherapy and, using weekly cone beam computed tomography (CBCT), char...

A sequential screening strategy for inherited susceptibility genes in endometrial cancer

Abstract Objective Current screening strategies for hereditary endometrial cancer (EC) have limitations. This single-center study aimed to evaluate a novel sequential screening strategy for identifying hereditary EC in an unselected cohort. Methods All patients newly diagnosed wi...

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

ABSTRACT The accumulation of mutant huntingtin (mHTT) aggregates drives the pathology of Huntington's disease (HD), yet therapies capable of distinguishing toxic species from wild‐type proteins remain elusive. Here, a synthetic gene circuit, termed ARAA, was engineered to couple...

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

ABSTRACT Diabetic Foot Ulcer (DFU), a severe chronic diabetes complication with low healing and high recurrence rates, is a major global health challenge. Overexpression of matrix metalloproteinase‐9 (MMP‐9) and the consequent MMP‐9/TIMP1 (tissue inhibitor of metalloproteinase 1)...