Chinese Academy of Medical Sciences & Peking Union Medical College

Spliceosome gene mutations synergize with anthracyclines to amplify atrial fibrillation risk in hematologic malignancies: a multicenter cohort study with discovery and validation

Abstract Background Atrial fibrillation (AF) is a life‑threatening complication in patients with hematologic malignancies, yet personalized risk stratification remains challenging. Spliceosome gene mutations are key drivers of these malignancies, but their specific role in AF pat...

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Case report on new injection method for treating female Meige syndrome patients

Meige syndrome is an uncommon, long-lasting, and recurring form of craniofacial focal dystonia marked by bilateral blepharospasm and involuntary facial muscle contractions that greatly disrupt the daily activities and social interactions of those affected. The primary minimally i...

CX3CR1⁺ CD8⁺ cytotoxic T cells drive tumor killing in esophageal squamous cell carcinoma during neoadjuvant therapy

Immune checkpoint inhibitor (ICI) responses in esophageal squamous cell carcinoma (ESCC) are highly variable, and the immune mechanisms underlying therapeutic sensitivity remain unclear. Here we show, using single-cell RNA, T-cell receptor and whole-exome sequencing of 52 ESCC pa...

ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility

Fatty Acid Oxidation (FAO) dysfunction induces pro-fibrotic transition in tubular epithelial cells (TECs) and contributes to renal fibrosis in chronic kidney disease (CKD); however, the drivers of metabolic reprogramming in TECs remain unclear. We investigate the role of aldehyde...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Mechano‐Electrical Coupling Scaffold Drives Bone Organoids Bioenergetic Reprogramming to Accelerate Bone Regeneration

ABSTRACT Critical‐sized bone defects remain a major clinical challenge in orthopedics and regenerative medicine. Bone organoid provided therapy potentials; however, current engineering strategies generally neglect the bioenergetic foundation and intrinsic mechano‐electrical coupl...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how t...

Amyotrophic lateral sclerosis coexisting with primary sjögren’s syndrome: a clinical case series and exploratory transcriptomic analysis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron degeneration, while primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with prominent immune dysregulation. Although immune-related alterations have been i...

Ferroptosis-like cell death induced by Amomi Fructus phenolic compounds in SGC7901 gastric cancer cells: a network pharmacology and experimental validation study

Abstract Background To investigate the mechanism of Amomi Fructus phenolic compounds (AFPC) induced ferroptosis-like cell death in gastric cancer (GC) using a multiomics strategy combining network pharmacology, molecular dynamics simulations (MDS), and experimental validation. Me...

Economic and social modulations of innate decision-making in mice exposed to visual threats

When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, which often require cognitive c...

Surgical Technique for Deep Concha, a Pseudomeatus, and High Projection in Congenital Auricular Reconstruction

BACKGROUND: Despite successful cartilage framework construction and auricular elevation in 2-stage reconstruction, achieving adequate conchal cavity depth and auricular projection remains challenging. This study introduces a systematic third-stage refinement technique incorporati...

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

Purpose To characterise regional and topographic choroidal thickness (CT) profiles using ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) and to compare topographic CT between normal eyes and eyes with pachychoroid disease. Methods All participants underwent...

Endpoint-specific associations of the cholesterol, high-density lipoprotein, and glucose (CHG) index and its adiposity- and inflammation-related derivatives with incident cardiovascular disease and mortality: evidence from CHARLS and NHANES

The cholesterol-high-density lipoprotein–glucose (CHG) index combines lipid and glycemic measures, but whether its adiposity- and inflammation-related derivatives add information beyond their components and established risk factors is uncertain. We compared nine CHG-related indic...

Impact of extreme rainstorm on the spatial distribution of population exposure in Haihe River basin in China

Abstract Based on daily rainfall data from 252 national meteorological stations in the Haihe River Basin of China during 1961–2023, rainstorm events were divided, and four characteristic variables representing the hazard index of rainstorms were statistically analyzed, including...

Gut microbiota-driven hippuric acid hydrolysis promotes pancreatic tumorigenesis by suppressing NK cell activity

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by a lack of effective early detection, profoundly immunosuppressive microenvironment, and poor responsiveness to current therapies. Emerging evidence suggests that gut microbiota a...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

Occurrence of FLT3 mutations in acute myeloid leukemia and comparison of different methodologies

Fms-like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of adult patients with acute myeloid leukemia (AML) and are clinically significant for prognosis and targeted therapy. Detection early is essential for treatment decisions. This study evaluated the performance...

A de novo IKZF4 Variant Underlies Hypogammaglobulinemia and Increased Infection Susceptibility through Downregulating the NF-κB Pathway

Inborn errors of immunity (IEI) are a group of complex diseases characterized by reduced immunity and increased susceptibility to external pathogens, autoinflammation, autoimmune conditions, and/or malignancy. The IKAROS zinc-finger ( IKZF ) family is a group of C2H2 zinc-finger...