Chinese Academy of Medical Sciences & Peking Union Medical College

Complete staging surgery and radioiodine therapy were predictive of disease progression of malignant struma ovarii: a retrospective study from a single-center in China and literature review

Malignant struma ovarii (MSO) is a rare subtype of ovarian cancer. We aimed to evaluate the role of complete staging surgery (CSS) and adjuvant radioiodine therapy in this rare malignancy. MSO patients with sufficient information who were treated at the Cancer Hospital & Institut...

Preclinical characterization and first-in-human phase I dose-escalation results with JYB1907, a novel anti-GARP-TGF-β1 complex monoclonal antibody in patients with advanced solid tumors

Transforming growth factor-β1 (TGF-β1) promotes immunosuppression in the tumor microenvironment via the GARP-latent TGF-β1 complex on regulatory T cells. JYB1907 is a humanized IgG4 monoclonal antibody targeting this complex. Preclinically, JYB1907 bound GARP-latent TGF-β1 comple...

Associations between non-insulin-based insulin resistance surrogates and pulmonary hypertension due to left heart failure: a multicenter cohort study

Abstract Background Insulin resistance (IR) has been reported to have a close relationship with the development and adverse outcomes of various cardiovascular disorders, while its association with pulmonary hypertension due to left heart failure (PH-HF) remains to be elucidated....

Neutrophil to Lymphocyte Ratio and Neurological Outcome in Ischemic Stroke at 4.5 to 24 Hours: A Post Hoc Analysis of TRACE-III Trial

Whether neutrophil to lymphocyte ratio (NLR), as a marker of increased inflammatory response, modifies the efficacy and safety of tenecteplase is uncertain in patients 4.5–24 h after stroke onset. We investigated this in the Tenecteplase Reperfusion Therapy in Acute Ischemic Cere...

Bone-targeting engineered exosomes delivering teriparatide mRNA for the treatment of osteoporosis

Introduction Teriparatide (TPTD) is an established osteoanabolic agent for the treatment of osteoporosis; however, its short circulating half-life necessitates repeated administration, while limited skeletal selectivity may reduce delivery efficiency. To address these limitations...

Surgical management of dissecting cellulitis of the scalp: a narrative review of techniques, patient selection, and integration with medical therapy

OBJECTIVE: To summarize surgical objectives, indications, technical principles, limitations and reconstructive considerations for dissecting cellulitis of the scalp (DCS), and explicitly distinguish DCS‑specific evidence from data extrapolated from hidradenitis suppurativa (HS)....

Special Issue “Natural Products in Drug Discovery and Development: 2nd Edition”

The Special Issue “Natural Products in Drug Discovery and Development” returns for a second edition at a time when nature-derived molecules continue to demonstrate their enduring value to medicine [...]

A Standalone Flavoprotein Monooxygenase Directs Divergent Tropolone Skeletal Editing through Baeyer–Villiger-Triggered Rearrangement

Abstract Late-stage oxidative remodeling of tropolone cores underpins the remarkable scaffold diversity in fungal meroterpenoid biosynthesis. However, the mechanistic basis by which a single enzymatic catalyst diverts a common substrate toward carbon-excising ring contraction ver...

Development of a Potent and Isoform-Selective HDAC11 Inhibitor with Anti-Tumor Efficacy against Non-Small Cell Lung Cancer

Abstract Targeting histone deacetylase 11 (HDAC11) represents a promising therapeutic strategy, yet developing selective inhibitors for solid tumors remains a formidable challenge. Herein, we describe the rational lead optimization of a novel series of indole-based hydroxamic aci...

Distinct Etiological and Clinical Patterns of Acute Mesenteric Ischemia at High Altitude: A Retrospective Comparative Study

Chen, Chen, Yang, Li, Xu, Fan, Xu, Zhijuan Liu, and Dong Wu. Distinct etiological and clinical patterns of acute mesenteric ischemia at high altitude: a retrospective comparative study. High Alt Med Biol. 00:00–00, 2026. Background: Acute mesenteric ischemia (AMI) is a life-threa...

Age at first live birth modifies the association between age at menarche and breast cancer risk in the UK Biobank cohort

Abstract Background Early menarche is an established risk factor for breast cancer (BC), but it remains unclear whether this elevated risk can be modified by later-life reproductive events. Methods We analysed data from 254,578 women in the UK Biobank using Cox proportional hazar...

Exploiting Asymmetric Mismatch Sensitivity of Cas13a for Interference-Tolerant Single-CpG Methylation Analysis

Abstract Accurate single-CpG methylation analysis in dense regions is critical for cancer diagnostics but challenged by adjacent CpG interference. Here, we developed EPICATCH, an interference-tolerant ratiometric Cas13a biosensor to overcome this limitation. Exploiting LbuCas13a′...

Relationships among self-perceived burden, fear of progression, and psychological capital in postoperative lung cancer patients

This study examined the relationships among positive psychological capital (PsyCap), fear of progression (FoP), and self-perceived burden (SPB) in postoperative patients with non-small cell lung cancer (NSCLC), with a focus on the mediating role of PsyCap. A total of 251 patients...

Electronic Interactions in Co/Cu Biotomic Nanozymes for Catalytic Eradication of Gram‐Positive Bacterial Biofilms

ABSTRACT Biofilm‐associated infections caused by Gram‐positive pathogens remain highly resistant to conventional antibiotic therapy due to restricted drug penetration and persistent inflammatory microenvironments. Inspired by the catalytic versatility and biocompatibility of coba...

Commutability Assessment of Materials for Serum Copper Measurement Using the IFCC Difference-in-Bias and the CLSI EP30 Approaches

Background: Evidence on the commutability of material for serum copper when assessing multiple material categories and assay pairs remains limited. Methods: We evaluated 21 reference materials for serum copper across four routine colorimetric systems and an inductively coupled pl...

Clinical significance of intramammary lymph nodes in female primary breast cancer: a systematic review and meta-analysis

Intramammary lymph nodes (IntraMLNs), located within the breast parenchyma or axillary tail, are uncommon, and their clinical significance in primary breast cancer remains unclear. This meta-analysis evaluated the association between IntraMLN and axillary lymph node (ALN) status,...

Triple Genetic Alterations (EGFR Mutation, ALK Fusion, and MET Polysomy) in Gynecological Metastasis of Lung Adenocarcinoma Patient with Acquired Resistance to Furmonertinib: A Case Report

For advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations, targeted therapy is the standard first-line treatment, but acquired resistance and disease progression are inevitable. Identification of resistance mechanisms is crucial for gu...

Central Nervous System Vasculitis Mimicking Glioma in a Patient With Ulcerative Colitis: A Case Report and Literature Review

A patient with ulcerative colitis presented with progressive memory impairment and alexia, with brain imaging showing a mass-like lesion mimicking glioma. Histopathology confirmed central nervous system (CNS) vasculitis. The patient's memory and reading ability improved and final...

Event-Weighted Desaturation Burden and Cardiovascular Mortality in Sleep Apnoea: Findings from a Large Community-Based Prospective Cohort

BACKGROUND AND AIMS: Obstructive sleep apnoea's prognostic value is limited by reliance on the apnoea-hypopnoea index (AHI), which fails to capture physiological heterogeneity of respiratory events. We developed a composite metric, event-weighted desaturation burden (EWDB), integ...

Accelerated Glofitamab as Urgent Bridging to CAR T‐Cell Therapy in High‐Risk Relapsed/Refractory Large B‐Cell Lymphoma

Conventional glofitamab step-up dosing reaches the 30-mg target dose approximately 3 weeks after obinutuzumab. This interval may be difficult to accommodate in patients with relapsed or refractory large B-cell lymphoma (R/R LBCL) who require disease control within days before cel...