Research works

Dual effect of α-synuclein disease variants on condensate formation

Abstract α-synuclein is a pre-synaptic protein implicated in synucleinopathies including Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent studies have re...

Polarization Measurement of Gamma-Ray Bursts with Fermi-GBM: The Case of GRB 180720B

Abstract To achieve confident nonzero polarization measurements for gamma-ray bursts (GRBs) we need sensitive polarimeters and bright GRBs. Here we report on the polarimetric analysis of the bright GRB 180720B using the Fermi Gamma-ray Burst Monitor (GBM). We rely on the detectio...

Diversified food fortification portfolios can enhance coverage of micronutrient-vulnerable populations in West Africa

Abstract Food fortification is central to addressing micronutrient deficiencies in West Africa and elsewhere. Yet evidence remains limited on whether current staple food fortification vehicles equitably reach vulnerable populations and whether candidate vehicles warrant inclusion...

Habitat destruction of the Victorian lowland temperate native grasslands, and the pending fate of the fat-tailed dunnart ( Sminthopsis crassicaudata )

Victorian lowland temperate native grasslands are among the most endangered ecosystems globally. At broad scale, they are classified into two primary climatic types: semi-arid and mesic lowland grasslands, and both habitats are threatened from dramatic habitat destruction, invasi...

Transport accessibility from the tourist perspective: a qualitative content analysis of Google reviews on public transport and airports in Kazakhstan

Purpose This study examines transport accessibility barriers in Kazakhstan from the tourist perspective. It focuses on Google Maps user reviews related to airports, railway stations, buses and taxi services. The study aims to identify how transport accessibility barriers are expe...

Proprioception drives tension wood formation for autotropic straightening and postural control in trees

Postural control in plant shoots relies on gravi- and photo- tropisms, driven by angular sensing and actuated by differential growth or reaction wood formation (tension wood in dicots). Control theory and kinematical models predict that posture stabilization additionally requires...

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Abstract Objective To assess the number, timing, characteristics, and scholarly impact of secondary publications generated using individual participant level data (IPD) from a portfolio of clinical trials shared with external investigators through a data sharing platform. Design...

Chronic exposure to aflatoxin B1, ochratoxin A, and citrinin in women and children and associated health risk characterization: blood biomonitoring evidence from rural Bangladesh

Abstract Dietary exposure to mycotoxins—including aflatoxins (AFs), ochratoxin A (OTA), and citrinin (CIT)—represents an important health risk, particularly in low-resource settings with widespread food contamination. This study investigates mycotoxin exposure among 712 participa...

An empirical assessment of data sharing and computational reproducibility in sociology

Abstract Public sharing of data and analysis code enables independent verification of published findings. While audit studies have examined data and code sharing in psychology, economics and political science, comparable evidence for sociology remains limited. We examine 730 empi...

Deep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itch

ABSTRACT: Naturally occurring pain and itch disorders in the domestic dog represent an important and underexploited opportunity for translational sensory neuroscience. These conditions largely mirror human disease, highlighting the need for detailed comparative understanding of c...

The physicochemical design, structure and permeability of the JCVI-syn3A minimal cell membrane

Abstract Minimal cells offer a platform to uncover the fundamental physicochemical principles of cellular life. While genomes, proteomes and metabolic networks of cells have been elucidated, the lipidome, which determines the physicochemical identity of the membrane, remains larg...

An improved RT-DETR algorithm for small-object detection in UAV aerial images

Abstract To address the challenges of UAV aerial imagery, including the prevalence of small objects, complex background interference, and difficulty in feature extraction that lead to high missed detection rates and compromise detection accuracy in existing RT-DETR algorithms, th...

Automated segmentation and length measurement of metacarpal and phalangeal bones for hand radiograph evaluation

Abstract Evaluating hand and wrist radiographs is essential in pediatric endocrinology and clinical genetics, particularly for the assessment of suspected skeletal anomalies. In this study, we present Auto-Bone-Caliper, an automated system for the segmentation and length measurem...

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

ABSTRACT The difructose dianhydride I synthase/hydrolase catalyzes the reversible transformation of inulobiose into difructose dianhydride I, a component of caramel. The proposed reaction mechanism of such a transformation consists of a glycosylation step followed by a cyclizatio...

Reducing Spatial and Temporal Dimensionality in the Multidimensional Caldeira-Leggett Model

Focusing on the real-time dynamics of the reduced density matrix of the multidimensional Caldeira-Leggett model, several techniques are adopted in this paper to reduce the spatial and temporal dimensionality, combined into an efficient algorithm. From a spatial perspective, an eq...

Potential of temperate agroforestry systems to deliver ecosystem services: An evidence map

Abstract. Agroforestry systems are promoted as multifunctional land-use strategies, yet evidence of their benefits, especially in temperate regions, remains fragmented. This umbrella review maps 42 meta-analyses to quantify the effects of agroforestry on environmental, climate, a...

DEMands of Precision: How DEM Resolution Shapes Various Flood Applications

Digital elevation models (DEM) form the backbone of flood related studies. Proper selection of the DEM product is critical to obtain reliable estimates. Most studies aimed at understanding DEM resolution impacts focus on geometric comparisons. A comprehensive structural and funct...

Perplexity as a metric for isoform diversity in the human transcriptome

-an interpretable measure derived from entropy-that quantifies the effective number of isoforms per gene based on the full, unfiltered isoform ratio distribution. Calculating perplexity for 124 ENCODE4 PacBio LRS datasets spanning 55 human cell types, we show that it provides int...

AMPK γ-Subunit Isoform Switching Governs Temozolomide Resistance and Survival in Glioblastoma

Temozolomide (TMZ) resistance remains a fundamental obstacle in the treatment of Glioblastoma (GBM). While the metabolic sensor AMPK is known to influence cancer cell survival, the specific role of its regulatory γ-subunit isoforms in orchestrating chemoresistance is poorly under...

Septin architecture dictates size-dependent diffusion barriers on biomimetic membranes

Abstract Septins are cytoskeletal filaments bound to the inner leaflet of the plasma membrane, essential for cell division. They are involved in the formation of diffusion barriers for membrane-bound components. Whether septins directly function as barriers or as part of a broade...