Research works

Direct evidence of apex–hypha interactions during vegetative growth of fungal thallus via comprehensive network and trajectory extraction

Abstract The mycelium of a filamentous fungus is a growing, branching network of numerous entangled hyphae exhibiting polarized apical growth. Expansion occurs during the vegetative phase from a single ascospore, driven by the need to explore and occupy surrounding space—limiting...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

Cutting Along a Symmetric Quadrilateral to Construct an Embedded Flexible Dodecahedron

Abstract Until recently, the simplest known flexible polyhedron embedded in Euclidean three-space was Steffen’s polyhedron on nine vertices. However, in 2024, an embedded flexible polyhedron on eight vertices was discovered. It attains the known lower bound for the number of vert...

A Fully Discrete Truly Multidimensional Active Flux Method for the Two-Dimensional Euler Equations

Abstract. The active flux method is a finite volume method for hyperbolic conservation laws that uses both cell averages and point values as degrees of freedom. Several versions of such methods are currently under development. We focus on third order accurate, fully discrete acti...

The algebraic structures of social organizations: the operad of cooperative games

The main goal of this paper is to settle a conceptual framework for cooperative game theory in which the notion of composition/aggregation of games is the defining structure. This is done via the mathematical theory of algebraic operads: we start by endowing the collection of all...

Sums of Schubert structure constants with bounded Coxeter length

Pak–Robichaux recently introduced a signed puzzle rule for Schubert structure constants, which they use to show that sums γ k ( n ) of these constants with a bounded number of inversions are polynomial. We give a different, conceptual proof that γ k ( n ) is (eventually) polynomi...

Shuffle Tableaux, Littlewood–Richardson Coefficients, and Schur Log-Concavity

We give a new formula for the Littlewood–Richardson coefficients in terms of peelable tableaux compatible with shuffle tableaux, in the same fashion as Remmel–Whitney rule. This gives an efficient way to compute generalized Littlewood–Richardson coefficients for Temperley–Lieb im...

Sensitivity-Driven Adaptive Surrogate Modeling for Simulation and Optimization of Dynamical Systems

Abstract. This paper develops a surrogate model refinement approach for the simulation of dynamical systems and the solution of optimization problems governed by dynamical systems in which surrogates replace expensive-to-compute state- and control-dependent component functions in...

Fast Flexible LSQR with a Hybrid Variant for Efficient Large-Scale Regularization

Abstract. A wide range of applications necessitates solving large-scale ill-posed problems contaminated by noise, which are commonly formulated as linear approximation problems (possibly overdetermined or underdetermined). Krylov subspace regularization methods are particularly a...

Rehabilitation and management interventions for people with chronic musculoskeletal condition/s and mental distress: a systematic scoping review

Abstract Background Musculoskeletal (MSK) conditions and mental distress present significant challenges for rehabilitation services. Currently, mental and physical healthcare is often segregated despite growing recognition for integrative interventions. This review aimed to map o...

An analysis of energy needs and seawater-extraction approaches for the integration of primary magnesium production with nuclear power

The cost of primary magnesium production is highly dominated by the energy required to produce the metal. This, along with the current geographical concentration of its production, makes the magnesium price vulnerable as energy-production paradigms begin to rapidly change. In thi...

Stability of stream biofilm community composition to transient shifts in dissolved organic carbon characteristics

Abstract. Microbial communities within biofilms are widely recognised as important contributors to ecological food webs and elemental cycles within stream systems. Yet, little is known about how these biofilm communities respond compositionally to storm-event-driven changes in di...

Wet-Spun Supramolecular Lignin/Alginate Fibers from Agricultural Residues

Abstract Purpose This is the 1st study to explore the development of fully biobased lignin/alginate fibers using lignin extracted from corn stover via the CELF process. It examines how lignin molecular weight and concentration affect fiber properties for sustainable material appl...

Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression

ABSTRACT Objective Stanford Neuromodulation Therapy (SNT) has demonstrated impressive efficacy for treatment-resistant depression (TRD), but its neurophysiological mechanisms remain poorly understood. This study investigated the neurophysiological correlates of SNT using transcra...

Public perception and segmentation of agricultural protests in Germany

Abstract Using Germany as a case study, this paper examines public perceptions of agricultural protests across different societal segments. Based on quota-representative survey data from 637 adult individuals collected in 2024, we employ factor and cluster analyses to identify di...

Refined expansions of the skew-stickiness ratio in stochastic volatility models

Building on the celebrated Bergomi–Guyon expansion, we derive next-to-leading order expansions in the volatility-of-volatility parameter for the Skew-Stickiness Ratio—an indicator of implied volatility dynamics—within a general class of forward variance models, thus pursuing the...

SLFN11 enhances cisplatin sensitivity in pediatric cancer via activation of stress-response and suppression of survival pathways

Abstract Background Paediatric cancers pose treatment challenges due to biological heterogeneity and variable chemotherapy responses. SLFN11, a DNA/RNA helicase-like protein known to sensitise adult tumours to DNA-damaging agents, remains underexplored in paediatric malignancies....

Optimal Vaccination for Contagious Diseases with Seasonal Transmission

Abstract We study optimal periodic time-dependent vaccination strategies for seasonal epidemics with waning immunity, aiming to minimize the basic reproduction number under a fixed annual vaccine supply. Our analysis, which does not pre-assume the structure of the vaccination pro...

Concurrent ETV6::ABL1 and BCR::ABL1 in a rare case of chronic myeloid leukemia: a paradox of imatinib resistance and indolent clinical course

Abstract Chronic myeloid leukaemia (CML) is characterized by the presence of BCR::ABL1 showing favorable response to imatinib therapy. Complex rearrangements in CML are indicative of clonal evolution and often associated with disease progression and poor response to therapy. Cyto...

Mouse bio-behavioral phenotyping using a digital homecage framework for long-timescale, high-resolution, and multi-factor data collection and analytics

Long-term monitoring of behavioral and physiological processes is essential for elucidating complex brain-based phenomena and disorders that develop over extended periods, such as chronic stress, circadian disruption, and metabolic syndromes. Though digital phenotyping is well-es...