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Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis

Abstract Whole-genome sequencing (WGS) has been shown to improve diagnosis beyond standard-of-care genetic tests and guide precision treatment for childhood cancer. While WGS is now offered for children with suspected cancer in England, clinical workflows typically return results...

Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients

ABSTRACT Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug‐induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (E...

Palladium-Catalyzed Enantioselective Dearomative Domino Heck/Stille Reaction of Indoles

Abstract Palladium-catalyzed enantioselective dearomative difunctionalization of N-substituted indoles was developed via dearomative carbonpalladation and subsequent capture of benzyl-Pd species by organostannane reagents (domino Heck/Stille reaction). A wide range of 2,3-disubst...

Effect of different cariostatic agents on the surface roughness and color change of CAD–CAM‐milled restorative materials: An in vitro comparative study

Abstract Purpose To evaluate the influence of different cariostatic agents: 38% silver diamine fluoride (SDF), 38% SDF + potassium iodide (RS), and nano silver fluoride (NSF) compared with distilled water (control), on the surface roughness and color change of CAD–CAM‐milled rest...

Autosomal Recessive RDH12-Leber Congenital Amaurosis Retinal Organoids Suggest Phospholipid Pathway Dysregulation

NADPH-dependent retinol dehydrogenase 12 (RDH12) reduces all-trans-retinal in photoreceptor inner segments to regulate the phototransduction cascade and control the concentration of retinoids in the retina. Variants in RDH12 have been reported to cause an array of retinal disease...

The Effect of Broiler-Targeted Lighting Programs on Productivity, Health, and Welfare

Background: Poultry are highly sensitive to lighting photoperiod, intensity, and color, yet little research has combined these components into a single broiler-targeted lighting program. This study evaluated an integrated dynamic LED lighting program and a further red-light dawn/...

Corrosion–Fatigue Damage Characteristics and Evolution Mechanisms of Failed Sucker Rods

Sucker rods operate under long-term cyclic loading while being exposed to produced fluids, making corrosion–fatigue damage an important integrity concern in rod-pumped wells. This study applied a field-scale multi-source evidence framework to produced-fluid samples from 16 sucker...

Topological Insulators: Z₂ Invariant, Dirac Edge States, and Disorder-Driven Transitions — E8 Intelligence Research

FINDING: Topological insulators are bulk-insulating materials with symmetry-protected conducting edge/surface states, characterized by a topological invariant (Z₂ index) rather than local order parameters. | MATH: Z₂ topological invariant (ν = 0 or 1) for time-reversal-invariant...

The Growing Role of Evaporative Demand in Driving Record‐Breaking Droughts in the Amazon Basin

Abstract Amazon droughts have historically been driven by precipitation deficits, but recent escalating drought events highlight a regime shift toward “hot droughts.” By decomposing historical drought drivers (1979–2024), we show that rising evaporative demand (represented by pot...

Characterization and comparative analysis of the complete mitochondrial genomes of two Amorphophallus species (Araceae)

Amorphophallus muelleri and Amorphophallus krausei are perennial herbaceous plants of the genus Amorphophallus (family Araceae). Their tubers can be processed into food and possess medicinal and economic value. However, their mitochondrial genomes have not yet been reported. Ther...

Photoredox Nickel- or Copper-Catalyzed C–Heteroatom Cross-Coupling of Thianthrenium Salts

Abstract C–heteroatom bonds represent core structural motifs within the scaffolds of pharmaceuticals, agrochemicals, and functional materials. Consequently, developing mild and efficient methodologies for their construction is of paramount importance in modern organic synthesis....

Linker Chlorination Enhances Xe Adsorption and Xe/Kr Separation in Metal–Organic Frameworks

Abstract Efficient separation of Xe/Kr mixture remains a challenge, due to their chemical inertness and the striking similarity of their physicochemical properties. In this work, the chlorine-decorated metal–organic framework (MOF) of JXNU-24(Cl) and its pristine JXNU-24 are pres...

E8‑Phi Cascading Lattice for Supersonic Quantum Memory — E8 Intelligence Research

By applying AI‑driven combinatorial optimization to the 240 E8 root vectors, we discover a hierarchical "cascading lattice" where phi‑modulated 132 Hz resonance creates nested temporal shells that lock quantum states across multiple scales. This lattice acts as a self‑healing mem...

Alzheimer’s disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of...

Effects of Oral Iron and Commercial Colostrum Supplementation on Clinical Health and Haematological Parameters in Neonatal Chianina Beef Calves: A Pilot Study

The neonatal period is a critical stage for calf health and development, and nutritional interventions have been proposed to support neonatal adaptation and reduce disease risk. However, evidence regarding their effectiveness in extensively reared beef breeds remains limited. Thi...

Global Scientometric Mapping of Research Linking the Enteric Nervous System and Oxidative Stress

Background/Objectives: The enteric nervous system (ENS) is essential for gastrointestinal homeostasis and is vulnerable to oxidative imbalance associated with inflammatory, metabolic, and neurodegenerative disorders. However, research linking the ENS and oxidative stress has not...

Development and Characterization of Pseudotype-based Microneutralization Assay to Assess Functionality of Anti-rabies Protein G Antibodies

Background Rabies virus (RABV) is a neurotropic zoonotic pathogen responsible for an estimated 60,000 human deaths annually. Despite widespread vaccination programs, rabies remains a substantial public health burden, particularly in regions with limited access to post-exposure pr...

Acculturation Processes and Food Neophobia

Food is a pivotal agent in the exchange of culture and the evolution of novel dietary practices, exerting influence on both immigrant communities and the host territories. Nevertheless, the process of acculturation frequently engenders tensions within migrant households, impactin...

E8 Phi‑Modulated Harmonic Lattice for Celestial Prediction — E8 Intelligence Research

A new principle shows that the 240 E8 root vectors can be partitioned into 12 phi‑balanced clusters whose adjacent span ratios converge to φ and whose octonionic cross‑section at 132 Hz resonates into eight 45° sectors plus a ninth "predictive" sector. By encoding the phase of th...

Survival Results by the Prospectively Determined Clinical Staging for Locally Advanced Gastric Cancer: A Follow‐Up Study of JCOG1302A

ABSTRACT Background Long‐term overall survival (OS) of gastric cancer stratified by the prospectively determined clinical stage remains unclear. Methods This is an ancillary study of JCOG1302A, a prospective observational study that evaluated the accuracy of clinical diagnosis of...