Research works

LAB #3822 PROMISING: LEDGER BENCH: Apply filter: Pool density HIGH (>=90) — improves win rate from 32.5% to 34.0% (+1.5pp — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: Pool density HIGH (>=90) — improves win rate from 32.5% to 34.0% (+1.5pp, n=1800) SAME-WINDOW EFFECT: Applying the pool-density ≥90 filter over the current 10-trade window would have excluded th...

Advancing asparaginase-based therapy for acute lymphoblastic leukemia through computational immunoengineering and molecular dynamics simulations

L-asparaginase is a critical enzyme in the treatment of acute lymphoblastic leukemia (ALL); however, its clinical application is frequently limited by immunogenicity and hypersensitivity reactions. This study utilized a comprehensive computational pipeline that integrated immunoi...

Challenging colonial language ideologies: EAL student-teachers’ praxis in indigenous communities

Abstract In Mexico, English as an Additional Language (EAL)) seems perpetuated by language ideologies evoking coloniality. Conversely, indigenous languages in Mexico are regarded as communication between “Indians” and as “incomplete languages”. Within this ELT scenario, it seems...

Aggregate risk assessment of bisphenols A, S, and F among the general Korean population

Bisphenol A (BPA) and its substitutes Bisphenol S (BPS) and Bisphenol F (BPF) have been identified as endocrine-disrupting chemicals that affects reproductive functions. In Korea, BPA use has been restricted, resulting in increased utilisation of BPS and BPF as alternatives. Howe...

Expression of NECTIN-4 and TROP-2 in Resected Upper Tract Urothelial Carcinoma with and Without Preoperative Chemotherapy

Background Antibody-drug conjugates (ADCs) have transformed the treatment of urothelial carcinoma, yet upper tract urothelial cancer (UTUC) data remain limited. Objective We compared NECTIN-4 and trophoblast cell-surface antigen 2 (TROP-2) expression in UTUC specimens from treatm...

Selected Physical and Geotechnical Properties of Loess in Wairarapa Valley, New Zealand

Loess up to 10 m thick covers marine terraces, old river aggradation terraces, and gentle hill country slopes in Wairarapa, New Zealand. In the drier eastern and southern parts of Wairarapa, the loess is subject to dry summer and autumn and wet winter and spring in most years. Un...

Liquid-mediated mechanosynthesis of Zn-BDC coordination polymers via ball milling and twin-screw extrusion

Abstract Mechanochemical synthesis methods can offer a low cost, low waste route to prepare metal–organic materials (MOMs); however, the influence of liquid additives on phase formation remains understudied. In this work, the mechanosynthesis of Zn-BDC (BDC = benzene-1,4-dicarbox...

Estimation of Effective Dose Received by Caregivers During [ 18 F]FDG PET/CT Studies

Caregivers who assist patients during [18F]FDG PET/CT are exposed to ionizing radiation, particularly when close physical support is required. Limited real-world data are available about the actual doses received by caregivers during routine clinical practice. This study aimed to...

Relative Roles of Middle Ear Bulla Volume and Eustachian Tube Function in Diving-related Barotrauma: An Experimental Pressure Chamber Study in Guinea Pigs

Hypothesis: We hypothesized that isolated changes in middle ear air volume do not increase the risk of diving-related middle ear barotrauma, and that Eustachian tube function is the primary determinant of barotrauma development. Background: The relative contributions of middle ea...

Gaze and Facial Expression‐Based Multimodal Network for Depression Assessment in Young Adults

ABSTRACT Depression remains a critical mental health challenge worldwide, particularly among young adults. Traditional assessment methods often raise privacy concerns and can heighten psychological resistance. To overcome these barriers, we introduce the Gaze and Facial Expressio...

Physical Activity and Risk of Liver Cancer: A Competing Risk Analysis

Physical activity is associated with lower risk of liver cancer, but obtaining an unbiased estimate of the causal effect is challenging due to the competing risk of death due to any other cause. We performed a causal competing risk analysis to estimate the total effect of physica...

Nonlinear dynamics of an eccentrically rotating flexible hub-beam system

Rotating axis eccentricity is a prevalent and virtually unavoidable challenge in rotating machinery and aerospace structures, stemming from geometric deviations introduced during manufacturing, assembly, or prolonged operation. This work investigates the nonlinear dynamics of a f...

Combined Maximum Tolerated Activity and Lesion-based Dosimetry for Personalized Radioiodine Therapy in Metastatic Differentiated Thyroid Carcinoma: An Early Institutional Experience

Objectives: Empirical fixed-activity radioiodine (RAI) therapy remains widely used in differentiated thyroid carcinoma (DTC), despite substantial inter-patient variability in iodine kinetics. Pre-therapeutic dosimetry offers a personalised approach by estimating radiation exposur...

Healthcare professionals’ views on expanding newborn screening with or without genomics in France: Results of the SeDeN-p2 study

Abstract Therapeutic advances and the rapid, cost-effective development of next-generation sequencing (NGS) have increased interest in expanding newborn screening (NBS) through genomics. The SeDeN-p2 study assessed the acceptability among healthcare professionals in France, of ex...

A global consistent database of plankton and detritus from in situ imaging by the Underwater Vision Profiler 5

Plankton and detritus are essential components of the Earth's oceans influencing biogeochemical cycles and carbon sequestration. Climate change impacts their composition and fluxes, and marine ecosystems as a whole. To improve our understanding of these changes, standardized obse...

Design and Mechanical Analysis of a 2-in-1 Integrated Self-Cleaning Particulate Filter and Acoustic Shell Damper for Emerging Markets

Title: Design and Mechanical Analysis of a 2-in-1 Integrated Self-Cleaning Particulate Filter and Acoustic Shell Damper for Emerging Markets Author: Mohamed Hadj Said, M.Sc. (Department of Mechanical Engineering, Abou Bekr Belkaid University, Tlemcen, Algeria) Executive Summary I...

Ecological momentary assessment of social context and physical activity: a systematic review

Abstract Background Physical activity is shaped by social context, yet most research relies on retrospective, cross-sectional measures that cannot capture the moment-to-moment social dynamics of daily life. Ecological momentary assessment (EMA) offers a methodologically distinct...

Beyond Human–AI Symbiosis: Toward a Population Ecology of Cognitive Hybrids

As prolonged interaction with artificial intelligence becomes increasingly integrated into human intellectual activity, the relevant unit of analysis may extend beyond individual users, AI models, and human–AI dyads. This paper proposes a population-level perspective in which per...

Evaluation of Drug-Associated Phototoxicity Under 980 nm Near-Infrared Laser Irradiation in Human Dermal Fibroblasts

Background: Many widely used drugs—including non-steroidal anti-inflammatory drugs, tetracyclines and thiazide diuretics—are labelled as photosensitising, yet their phototoxicity has been defined almost entirely by ultraviolet A (UVA) exposure. Whether this risk extends to the ne...

The spatial crises of capitalism and in-between spaces as an instrument of urban production: the case of Galataport

This study examines the ontological transformation of in-between spaces from the 1960s to the present, within capitalism’s spatial crises. While previous literature has viewed these spaces as idle voids or symptoms of spatial segregation, this study reimagines them as dynamic mod...