Palladium-Catalyzed Enantioselective Dearomative Domino Heck/Stille Reaction of Indoles
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Abstract
Abstract Palladium-catalyzed enantioselective dearomative difunctionalization of N-substituted indoles was developed via dearomative carbonpalladation and subsequent capture of benzyl-Pd species by organostannane reagents (domino Heck/Stille reaction). A wide range of 2,3-disubstituted chiral indolines bearing vicinal quaternary and tertiary stereocenters was efficiently synthesized in one step with excellent enantioselectivities and diastereoselectivities.
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Authors: Lu Chuan-Jun, Bingbing Huang, Fei Xie, Ren‐Xiao Liang, Yi‐Xia Jia, Renrong Liu
Institutions: Qingdao University, Zhejiang University of Technology, Tianjin University of Technology