Research works

Repurposing the Insecticide Flufenerim, the Only Anti- Cryptococcus Compound Identified in the MMV Global Health Priority Box, as a Candidate for the Environmental Control of the Cryptococcosis Agents

Abstract Cryptococcus neoformans and Cryptococcus gattii are environmental fungi that cause cryptococcosis, a severe, life-threatening infection, particularly in immunocompromised individuals. Current treatments are limited by toxicity, restricted availability, and the emergence...

Seropositivity and Antigen-Specific Seroreactivity to Leptospira spp. In Equids from Three Regions of Veracruz, Mexico

Information on Leptospira spp. exposure in Mexican equids remains limited. This cross-sectional study evaluated seropositivity and antigen-specific seroreactivity in 313 apparently healthy equids enrolled by convenience sampling in Los Tuxtlas (n = 119), Sotavento (n = 108), and...

Adaptive Graph Learning with Persona-Aware Attribution for Event-Resilient Metro Passenger Flow Prediction

Urban rail passenger flow forecasting, based on large-scale automatic fare collection (AFC) sensor networks, is typically evaluated on ordinary days, yet operators most need accurate predictions during event days. The AFC infrastructure comprises 191 sensor-equipped stations with...

Fundamental Theory of the Finsler-Mucini Formalism: Analytical Resolution of the Hubble Tension and Cosmic Fate

This work introduces the Finsler-Mucini formalism, a novel cosmological framework where spacetime geometry is extended from the purely positional Riemannian manifold to the tangent bundle TM, incorporating kinetic velocity, quantum frequencies, and local temperature. By introduci...

Diminished Ovarian Reserve in Advanced Endometriosis: Prevalence, Clinical Predictors, and Patient Awareness of Fertility Preservation

Background & Objective: Advanced endometriosis is recognized as a potential cause of Diminished Ovarian Reserve (DOR), yet data on its prevalence, predictors, and patient awareness in Central Asia are scarce. The present study was conducted with aim to determine the prevalence of...

Detection and genomic characterization of tet(X4)-positive Escherichia coli in retail pig products in Xuancheng, China

Tigecycline is considered a last-resort antibiotic against multidrug-resistant Gram-negative bacteria. The emergence of the mobile resistance gene tet (X4), which confers high-level resistance to tigecycline, has raised growing concern due to its rapid dissemination among humans,...

Nipsnap 1 deficiency shifts neuronal and synaptic signaling toward inflammatory pathway and impairs cognitive functions in the aging brain

Mitochondrial quality control is essential for maintaining neuronal function during aging. Nipsnap1 (Nip1), a mitochondrial protein involved in mitophagy, metabolic regulation, and cellular senescence, has emerged as a potential regulator of tissue homeostasis; however, its role...

Serum basic amino acids, prolactin, and insomnia severity in perimenopausal individuals: a cross-sectional sub-study

Insomnia symptoms are common during the menopausal transition, but estrogen-centered explanations do not fully account for inter-individual variation. We examined whether serum prolactin was associated with insomnia severity and whether circulating basic amino acids modified this...

E8 Topological Charge Pumps Drive Lymphatic Peristalsis Sequences — E8 Intelligence Research

The 40 hexagonal hexads of the E8 root system, when mapped onto the 40Hz interbout micro-arousal intervals observed during glymphatic clearance, define a quantized topological charge pump that drives peristaltic contraction sequences in meningeal lymphatic vessels. Each hexad con...

A Study on the Identification of Partial Discharges in Typical Defects of Cross-Linked Polyethylene Cables Using the CNN-SE-RAP Algorithm

To address the reliance on manual interpretation and the limited discrimination capability of conventional methods for highly similar phase-resolved partial discharge (PRPD) patterns in cross-linked polyethylene (XLPE) cables, a convolutional neural network incorporating squeeze-...

24h Extremely Low Frequency Electromagnetic Field Exposure Modulates Immune Responses in Rats

We examined the immune response induced by 24-hour continuous exposure to an ultra-low-frequency electromagnetic field (EMF) in white rats. We placed the experimental group wild-type albino rats in a special coil generating an electromagnetic field of 2 mT at a frequency of 50 Hz...

Serum BDNF, VEGF, and EGF Levels in Pregnant Women with Anxiety and Depression

Antenatal anxiety and depression frequently co-occur, negatively affecting maternal and offspring outcomes, yet their biological correlates remain insufficiently characterized. This cross-sectional study examined associations between anxiety and depressive symptoms and serum conc...

Training the next generation of minimally invasive HPB surgeons: are current fellowships crossing the learning curve?

Abstract Background Minimally invasive surgery (MIS) improved outcomes in hepatopancreatobiliary (HPB) cases, yet adoption is slowed by technical complexity and steep learning curves. This retrospective review sought to characterize MIS training variations across three fellowship...

Revisiting the relation between oral contraceptive use and attentional engagement in everyday life: The role of formulation

Oral contraceptives (OCs) are composed of artificial estrogen (ethinyl-estradiol) and/or progesterone (progestin), which can attach to receptors in the brain and potentially influence cognition. One prior study suggested that OC use was associated with increased mind-wandering –...

The Social Reality Inversion Curve (SRIC): A neuropsychiatric and social-cognitive framework of algorithmic delusion and collective epistemic erosion

Digital information ecosystems have altered the social conditions under which people encounter, repeat, evaluate, and challenge information. This conceptual paper introduces the Social Reality Inversion Curve (SRIC), a proposed model describing how affective salience, repeated al...

The domestic violence myth acceptance scale in Brazil: cross-cultural adaptation and initial construct-validity evidence

Domestic violence against women constitutes a structural public health problem. The original scale measures the endorsement of these beliefs but requires adaptation and psychometric validation for Brazilian Portuguese individuals. The aim of this study was to culturally adapt and...

Analysis of institutional governance for the development of climate-smart agriculture in Sistan and Baluchestan Province, Iran

The present study aimed to analyze the role of institutional governance in developing climate-smart agriculture (CSA) in Sistan and Baluchestan Province, Iran. Given the intensification of challenges caused by climate change and weaknesses in institutional coordination, the succe...

Diapausing adult female mosquitoes (Diptera: Culicidae) in overwintering sites in Estonia in 2023–2024: Species composition and variation

In temperate regions, several mosquito species overwinter as diapausing females in sheltered habitats, enabling them to serve as early-season vectors of mosquito-borne pathogens. While overwintering species compositions have been documented in several parts of Europe, no comprehe...

Streptococcus pneumoniae haemolytic uraemic syndrome in Aotearoa New Zealand across changing pneumococcal conjugate vaccine eras

Objective To describe the epidemiology, clinical features, microbiology and outcomes of paediatric Streptococcus pneumoniae haemolytic uraemic syndrome (SpHUS) in Aotearoa New Zealand across changing pneumococcal conjugate vaccine (PCV) eras. Design Retrospective case series. Set...

Efficient latent-vision enabled generative data augmented pipeline for medical image analysis with hybrid deep learning approach

Medical image analysis is an important process involved in diagnosing diseases, but a lack of data, class imbalance, and poor interpretability of deep learning models hamper it. In this study, these problems are overcome by proposing a hybrid generative data-augmented method for...