Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives
Abstract
Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodological approaches - from target trial emulation on observational data to functional genomics - offer a potential path towards precision immunopsychiatry and stratified immunomodulatory treatment.
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Authors: Tomáš Formánek, Mary-Ellen Lynall, Emanuele F. Osimo
Institutions: University of Oxford, University of Cambridge, Aarhus University, Cambridge University Hospitals NHS Foundation Trust, South London and Maudsley NHS Foundation Trust, Wellcome Sanger Institute, Cambridgeshire and Peterborough NHS Foundation Trust