Mary-Ellen Lynall

A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA

Depression with psychotic features is poorly understood, and the extent to which its biology is shared with other psychosis disorders is unclear. There is evidence for a genetic basis for MDD, but there has not been a major GWAS of the phenotype. We are conducting the first GWAS...

Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives

Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodologica...