Cambridgeshire and Peterborough NHS Foundation Trust

Management of Self-Harm in Adolescent Inpatient Settings Without Physical Restraint: A Service Evaluation of Physical Health Outcomes from a Least Restrictive Practice Unit

Purpose: To assess physical health outcomes for young people who self-harmed during admission to a general adolescent unit where physical restraint (PR) is proactively avoided in response to self-harm unless it is immediately life-threatening. Method: From the incident reporting...

Deep phenotyping of white matter tissue composition in dementia with Lewy bodies

Abstract Background White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue C...

Effectiveness of Interventions for Reducing Loneliness Among Adult Cancer Survivors: A Systematic Review and Meta-Analysis

Background/Objectives: Loneliness in adult cancer survivors is a frequent and disruptive psychosocial sequela with important consequences for overall health. Psychosocial interventions designed to address this issue are crucial. This systematic review and meta-analysis aimed to e...

Conversational Agent-Based CBT Intervention for Anxiety and Depression in Medical Students: A Pilot Randomized Feasibility Study

Background: Medical students experience substantially higher rates of anxiety and depressive symptoms than similarly aged members of the general population. Academic, financial, and social pressures, together with concerns about stigma, may discourage timely engagement with conve...

Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives

Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodologica...

P1.038. Minimising the Systemic Effects of an Oesophageal Leak Following High Risk Myotomy Repair Using Prophylactic Endoluminal Vacuum Therapy (EVT) – Time for a Change?

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Case Submission An 80 year old frail lady (ASA 2, BMI 22) was referred with progressive dysphagia, regurgitation, and unintentional weight loss. Endoscopy demonstrated a dilat...

Causes of death and mortality patterns in clozapine-treated patients: 17-year retrospective cohort study

Background Clozapine reduces overall mortality and suicide risk in schizophrenia, but the specific causes and clinical contexts of death among clozapine-treated patients remain less well characterised. Aims We aimed to characterise causes of death in clozapine-treated patients wi...

Evidence-based interventions for vocational recovery in first-episode psychosis: A meta-analysis of employment and education rates

Background: Young people with first-episode psychosis experience high rates of disruption in work and education and consistently describe vocational participation as a core priority of recovery. This meta-analysis aimed to evaluate the effectiveness of evidence-based intervention...

The Impact of Psychosocial Factors on Pain and Functional Outcomes After Rotator Cuff Repair: A Systematic Review

Introduction Outcomes after rotator cuff repair are commonly evaluated in terms of structural healing and surgical technique. However, psychological factors may also influence patients’ experience of pain and functional recovery. Increasing attention has therefore been directed t...