Wellcome Sanger Institute

ERGA-BGE reference genome of the bladderpod Alyssoides utriculata (L.) Medik. (Brassicaceae), a yellow-flowering shrub native to Switzerland

We present the chromosome-level genome assembly for bladderrpod, Alyssoides utriculata (Brassicales: Brassicaceae), the only currently accepted species in the genus Alyssoides. The phased assembly comprises two haplotypes with total lengths of 1.01 Gb and 0.98 Gb, respectively. F...

Dynamics of human cardiogenesis and its disruption in trisomy 21

Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches 1 . Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a c...

Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis

Abstract Whole-genome sequencing (WGS) has been shown to improve diagnosis beyond standard-of-care genetic tests and guide precision treatment for childhood cancer. While WGS is now offered for children with suspected cancer in England, clinical workflows typically return results...

An interpretable Day-1 machine-learning model for COVID-19 mortality and severity prognosis: development in a Pakistani hospital cohort and external evaluation in Chinese and Italian populations

Early risk stratification of COVID-19 patients at admission informs triage and resource allocation, particularly in low- and middle-income settings where intensive-care capacity is constrained. Most published models are not interpretable, rarely externally validated, and develope...

Uncovering lung virome signatures of COPD severity and acute exacerbations in longitudinally sampled AERIS cohort

Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized as a complex disorder in which microbial communities may modulate disease progression and exacerbation risk. We investigated the contribution of the respiratory virome to disease severity and acute exacerbati...

Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks...

Amphipods associate with epibiotic filamentous bacteria at a shallow-water hydrothermal vent

In the deep ocean, hydrothermal vents sustain remarkable animal-microbial symbioses, in which bacteria colonizing animal external or internal tissues use reduced chemicals from venting fluids to perform chemosynthesis and nourish their host. Hydrothermal vents also occasionally o...

Disentangling local adaptation and phenotypic plasticity in traits associated with altitude and temperature in widespread tropical butterflies

Climatic stratifications, in particular differences in temperature, occur along altitudinal clines. Understanding divergence across these regions can give insight into speciation and diversification, as well as how species may respond to climate change scenarios. Most past resear...

The Onychomys pangenome reveals the unique molecular adaptations that confer toxin resistance

Abstract Background Predatory grasshopper mice ( Onychomys sp.) have co-evolved resistance to painful and lethal neurotoxins produced by their scorpion prey. Previous studies have reported that structural and functional modifications of the sodium channel Nav1.8 block the effect...

The chromosomal genome sequence of the blushing star coral, Stephanocoenia intersepta (Lamarck, 1816) (Scleractinia: Astrocoeniidae) and its associated microbial metagenome sequences

We present a genome assembly from a specimen of Stephanocoenia intersepta (blushing star coral; Cnidaria; Anthozoa; Scleractinia; Astrocoeniidae). The assembly contains two haplotypes with total lengths of 656.21 megabases and 656.55 megabases. Most of haplotype 1 (94.84%) is sca...

The genome sequence of the Reed Tussock moth, Laelia coenosa (Hubner, 1808) (Lepidoptera: Erebidae)

We present a genome assembly from a female specimen of Laelia coenosa (Reed Tussock; Arthropoda; Insecta; Lepidoptera; Erebidae). The assembly contains two haplotypes with total lengths of 1,109.06 megabases and 795.63 megabases. Most of the haplotype 1 assembly (99.91%) was scaf...

The genome sequences of the diplonemid protist Diplonema japonicum YPF1604 and its bacterial endosymbionts Ca. Cytomitobacter primus and Ca. Nesciobacter abundans

We present a genome assembly of the diplonemid Diplonema japonicum YPF1604 (Discoba; Euglenozoa; Diplonemea; Diplonemidae). The genome sequence is 62.30 megabases in span. Most of the assembly is scaffolded into 118 chromosomal pseudomolecules. The multipartite mitochondrial geno...

A cytogenetic analysis with chromosome painting in typical antbirds (Passeriformes, Thamnophilidae) and an inference on chromosome evolution in Passeriformes

Abstract The typical antbirds (Passeriformes, Thamnophilidae) are a monophyletic group comprising 225 species in 45 genera, primarily distributed in the lowland forests of the Neotropics. There is limited karyotypic information for this bird family, including chromosome morpholog...

The chromosomal genome sequence of Pseudorhiza aurosa von Lendenfeld, 1882 (Rhizostomeae: Lychnorhizidae) and its associated microbial metagenome sequences

We present a genome assembly from a specimen of Pseudorhiza aurosa (Cnidaria; Scyphozoa; Rhizostomeae; Lychnorhizidae). The genome sequence has a total length of 183.49 megabases. The whole assembly is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has a...

The chromosomal genome sequence of the boulder star coral, Orbicella franksi (Gregory, 1895) (Scleractinia: Merulinidae)

We present a genome assembly from a specimen of Orbicella franksi (boulder star coral; Cnidaria; Anthozoa; Scleractinia; Merulinidae). The genome sequence has a total length of 496.97 megabases. Most of the assembly (95.24%) is scaffolded into 15 chromosomal pseudomolecules. The...

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

ABSTRACT The prevalence of antimicrobial resistance (AMR) within the common bacterial pathogen Streptococcus pneumoniae makes it a priority for the development of new antibiotics. While artificial intelligence (AI) has recently boosted phenotype‐based repurposing of drugs for oth...

Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa

Abstract Streptococcus pneumoniae is highly diverse, comprising over 100 serotypes and hundreds of genomic lineages amid widespread vaccination. While it can cause invasive pneumococcal disease (IPD) which exhibits pronounced seasonal spikes, the interplay between pneumococcal di...

Extensive and differential platinum chemotherapy mutagenesis in livers of children

Childhood cancer survivors often experience late adverse effects that may be linked to chemotherapy mutagenesis. We studied chemotherapy mutagenesis in normal pediatric tissues using duplex sequencing (NanoSeq) to enable the detection of mutations from single DNA molecules. We fo...

Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives

Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodologica...

Dual plasmepsin IX and X inhibitors are refractory to development of resistance

Abstract Artemisinin-based combination therapies (ACTs) remain the cornerstone of malaria treatment, but emerging resistance threatens their efficacy. The potential for the development of drug resistance against plasmepsin X (PMX)-selective inhibitors and dual plasmepsin IX/X (PM...