University of Oxford

“It All Exists Within Me”: A Qualitative Study Exploring Mental Health Service Experiences in Adults With Comorbid Eating Disorders and Emotionally Unstable Personality Disorder

ABSTRACT Objective Comorbidity between Eating Disorders (ED) and Emotionally Unstable Personality Disorder (EUPD) is high. This comorbidity is also linked with worse outcomes for traditional evidence‐based treatments. We aimed to improve mental health service experience for adult...

Hydration Asymmetry and Solvent-Mediated Charge Balancing in Microporous Carbons: An NMR Study of Aqueous and Organic Electrosorption

Abstract Aqueous electrolytes are attracting increasing interest in supercapacitor applications due to their high sustainability and ionic conductivity relative to conventional organic systems. However, the distinct solvation properties of water and their impact on (electro)sorpt...

Prevalence and healthcare utilization of eosinophilic chronic obstructive pulmonary disease in the UK: an observational electronic health record-based cohort study

Abstract Background Biologic therapies offer new treatment opportunities for patients with eosinophilic COPD. However, the number and proportions of patients with COPD who would be eligible are unknown. Methods Using data from Optimum Patient Care Research Database, we conducted...

Comparison of current treatment strategies for AMD-related submacular haemorrhage: Real-world outcomes

Abstract Purpose Comparison of available treatment modalities for neovascular AMD-related submacular haemorrhage including robot-assisted subretinal drug delivery. Methods Single centre, long-term, retrospective analysis of patients treated for nAMD-related submacular haemorrhage...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...

Competing Charge Separation Pathways Govern Charge Generation in Organic Photovoltaic Blends: Insights From Transient Electron Spin Resonance

ABSTRACT Understanding charge generation in organic photovoltaics remains a central challenge despite recent efficiency gains. Here, competing charge separation pathways in donor:acceptor blends are identified by directly probing photoinduced spin states using transient electron...

Balancing data quality and participant burden: a comparative analysis of abbreviated vs extended symptom diaries in the CanTreatCOVID trial

Abstract Background Symptom diaries are widely used in acute respiratory infection trials to capture patient-reported symptom severity and recovery. Longer questionnaires may provide a more complete clinical picture but can increase participant burden and reduce adherence. Eviden...

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health

Abstract Our Future Health is a prospective study aiming to recruit 5 million UK-resident adults to enable discovery and translation of disease prevention, detection and treatment approaches. So far, more than 2.5 million have enrolled, and baseline phenotypic data are available...

A topological approach to the Cahn–Hilliard equation and hyperuniform fields

Hyperuniform structures are disordered, correlated systems in which density fluctuations are suppressed at large scales. Such a property generalizes the concept of order in patterns and is relevant across diverse physical systems. We present a numerical characterization of hyperu...

A deliberately buried canid is not necessarily a dog

Canid interment, either alone or as part of a human burial, is a global phenomenon that has been documented over the last 15,000 years. In addition, burials have been used extensively to support the emergence of dog domestication in human societies based on the presumption that a...

On the Computation of Equilibria in Discrete First-Price Auctions

Abstract. We study the computational complexity of computing Bayes–Nash equilibria in first-price auctions with discrete value distributions and discrete bidding space under general subjective beliefs. It is known that such auctions do not always have pure equilibria. In this pap...

Rapid increase of climate extremes reveals new areas of concern in Amazonia

Abstract Amazonia is highly sensitive to climate extremes, yet we lack an Amazon-wide assessment that examines the spatial-temporal changes in these extreme conditions. We address this within seasons and across the hydrological year, using a quantiles approach that integrates the...

Analytical dilemmas in assessing efficacy of radical cure of vivax malaria

The radical cure for Plasmodium vivax malaria involves administration of blood schizontocidal drug(s) against the acute attack and a hypnozoitocidal drug for the prevention of relapse due to latent hepatic stages of the parasite.1 There are many options for the former but just tw...

Optimal execution and speculation with trade signals

Abstract We propose a price impact model where changes in prices are purely driven by the order flow in the market. The stochastic price impact of market orders and the arrival rates of limit and market orders are functions of the market liquidity process which reflects the balan...

The Contention of Care: A Latin American Perspective

ABSTRACT In the current global political landscape, characterised by increasing polarisation and a rise in far‐right conservative governments, ‘care’ has become a contested field. In particular, the decline in birth rates has catalysed conservative discourse advocating a return t...

Time and landscape context shape insular bat responses to wildfire

Abstract Background Wildfires are increasing in frequency and severity, yet their longer-term effects on island bats remain poorly understood. We assessed temporal and landscape-dependent patterns in bat activity following the 2016 wildfires on Madeira by resurveying 58 acoustic...

Environmental and host-associated determinants of microbiome variation in the brown dog tick Rhipicephalus linnaei in Thailand

Abstract Background The brown dog tick, Rhipicephalus linnaei , is an important vector of veterinary and zoonotic pathogens worldwide. The composition of the tick-associated microbiome may influence tick physiology, adaptation, and vector competence; however, factors shaping the...

Decoupling Triplet Population from Intersystem Crossing in TADF Materials

Abstract The characterization of thermally activated delayed fluorescence (TADF) relies on detecting delayed emission following triplet formation. However, triplet population under optical excitation is fundamentally limited by the intrinsic intersystem crossing (ISC) efficiency...

The Ethics of Growth-Promoting Pharmaceuticals for Achondroplasia

In 2021, vosoritide became the first pharmaceutical approved to treat the pathophysiology of achondroplastic dwarfism. It has generated significant ethical debate. Proponents emphasize its potential to improve quality of life and functional independence, whereas critics raise con...

Age-related changes in the gut microbiota of a long-lived seabird suggest divergence from mammalian models

Abstract Gut microbiota plays key roles in shaping host development, immunity, and physiology. The assembly of vertebrate gut microbiota during early life follows relatively predictable trajectories across several mammalian species, largely driven by maternal transmission routes....