Neuroscience · Biological Psychiatry
Researchers analyzed more than 6.3 million nuclei from the dorsolateral prefrontal cortex of 1,494 donors, including people with eight brain disorders and neurotypical controls. The atlas shows shared cellular changes across diseases, as well as disease- and stage-related differences in Alzheimer’s disease.
A study of male active-duty service members found that higher levels of natural antibodies targeting a brain receptor were associated with fewer depression and post-traumatic stress symptoms after traumatic brain injury. The antibodies were not associated with lower anxiety symptoms, and the findings do not show that they prevent psychiatric symptoms.
This narrative review discusses whether ketamine could be a candidate therapy for amyotrophic lateral sclerosis (ALS). It focuses on proposed mechanisms related to sigma-1 receptors, mitochondria, protein handling, inflammation, and neuroplasticity, but it does not present new clinical trial results in people with ALS.
