South London and Maudsley NHS Foundation Trust

A practical framework for exploring non-linear dose–response using adherence data in complex interventions

Abstract Background Randomised trials of complex interventions commonly estimate the effect of being offered treatment using intention-to-treat (ITT) analyses. However, in many settings, particularly psychological therapies, participants adhere to varying amounts of treatment. Es...

Meta-Analysis of ALS Post-Mortem Cerebral Cortex Transcriptome Studies Identifies Robust Shifts in Gene Expression Despite Significant Between-Study Heterogeneity

Background: ALS is characterized by motor neuron failure with potential neurocognitive comorbidity. Cortical neurons, and their support cells, exhibit pathologic features, some of which have been identified in post-mortem transcriptome studies of the cortex from ALS patients and...

Genetic evidence for the psychosis continuum: polygenic score analysis

Background The psychosis continuum conceptualises psychotic phenomena as existing on a spectrum from subclinical experiences to psychotic disorders. Despite epidemiological and clinical evidence in support of this model, few studies have examined polygenic liability across the se...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Exploring Positive Identity in Autistic Adolescents: A Feasibility and Acceptability Study of a Co-designed Group Intervention

BackgroundCultivating a positive identity may buffer against the adverse mental health outcomes often experienced by autistic individuals. Group settings can provide valuable spaces for identity consolidation. This study evaluated the feasibility and acceptability of a co-designe...

Considering Autism in Binge-Type Eating Disorders: Broadening Beyond an Anorexia Nervosa-Focused Model

PURPOSE OF REVIEW: Research on Autism in eating disorders (EDs) has historically focused on anorexia nervosa (AN), with comparatively limited attention given to binge-type EDs such as bulimia nervosa (BN) and binge eating disorder (BED). This review summarises emerging evidence o...

Meeting young people where they are – digital adaptations of CBT for psychosis: a real-world approach

Purpose Young people experiencing psychosis frequently disengage from traditional psychological therapies, while their routine use of digital technologies offers new opportunities to improve engagement, accessibility and continuity of care. This practitioner article aims to descr...

Young adults’ experiences of using FREED-Mobile, a smartphone friendly intervention designed to facilitate help-seeking for eating disorders

Abstract Background Early intervention increases the likelihood of eating disorder recovery, yet many young people delay seeking professional support for eating difficulties. We developed a smartphone-friendly, online intervention - FREED-Mobile [FREED-M] to encourage early help-...

The lived experience of trans persons: a bottom-up review co-written by experts by experience and academics.

We present here the first bottom-up review of the lived experience of trans persons, co-written by experts by experience and academics. We sourced the medical and non-medical literature, focusing on first-person narratives, and critically extracted experiential themes, which were...

Mental health disparities in LGBTQIA+ populations: an umbrella review of systematic reviews and meta-analyses.

Lesbian, gay, bisexual, transgender, questioning, intersex, asexual (LGBTQIA+) populations face unique social, political, psychological and health care-related challenges that contribute to marked mental health disparities. However, the overall strength and credibility of evidenc...

An etiological approach to psychosis: potential benefits for treatment, research and prevention.

Current treatment of psychosis focuses on antipsychotic medication, and rarely addresses the factors that have contributed to the onset and persistence of the disorder. We suggest that the most useful way of facilitating treatment, research and prevention is to identify the causa...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Neighbourhood-level variations in psychosis prevalence and involuntary psychiatric admissions

Studies have highlighted geographical variations in psychosis and involuntary psychiatric admissions. However, the association of neighbourhood-level factors on these variations remains underexplored. Aims To investigate geographical variations in psychosis prevalence and involun...

Considering ADHD in the context of eating disorders through a neuro-affirming lens

PURPOSE OF REVIEW: Research on neuro-affirming eating disorder (ED) care has expanded rapidly but has focused primarily on Autism. Attention to attention-deficit/hyperactivity disorder (ADHD) in ED populations has increased only recently. This review summarizes emerging research...

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis

Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10-20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and have bee...

Validity and reliability of the pica, ARFID and rumination disorder interview- ARFID questionnaire (PARDI-AR-Q) in Turkish adults

Avoidant/Restrictive Food Intake Disorder (ARFID) is increasingly recognized as a clinically significant eating disorder across the lifespan, yet psychometrically validated assessment tools in non-English-speaking adult populations remain scarce. The Pica, ARFID and Rumination Di...

“It All Exists Within Me”: A Qualitative Study Exploring Mental Health Service Experiences in Adults With Comorbid Eating Disorders and Emotionally Unstable Personality Disorder

ABSTRACT Objective Comorbidity between Eating Disorders (ED) and Emotionally Unstable Personality Disorder (EUPD) is high. This comorbidity is also linked with worse outcomes for traditional evidence‐based treatments. We aimed to improve mental health service experience for adult...

Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives

Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodologica...

Prevalence and Clinical Correlates of Autistic Traits Across Eating Disorder Diagnoses: A Retrospective Analysis of Clinical Service Data

Background: Autistic traits are overrepresented among individuals with anorexia nervosa (AN) and are associated with greater eating disorder (ED) psychopathology, psychological distress, and work and social functioning difficulties in this population. However, less is known about...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...