Yale University

Impact of the Food4Moms produce prescription program on readiness for healthy eating, fruit and vegetable intake, and food security

Abstract Produce prescription programs (PRx) targeting different populations and conditions have been found to be effective. However, few have focused on pregnant women. The objectives of this study were to assess the impact of the Food4Moms (F4M) PRx on 1) healthy eating stages...

The Randomization Effect in a Double-Blind Placebo-Controlled Depression Study

BACKGROUND: Double-blind, placebo-controlled trials are often affected by higher-than-anticipated placebo responses that may contribute to study failure. It is common to observe symptomatic improvement immediately after randomization regardless of treatment allocation. METHODS: T...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Intravenous Infusion of Mesenchymal Stem Cells Enhances Long-Tract Reorganization That Circumvents the Lesion in a Rat Staggered Hemisection Spinal Cord Injury Model

Background/Objectives: Non-contiguous dual spinal cord injuries are associated with poor neurological outcomes, probably due to reduced spared-tract bridges for compensatory reorganization. Intravenous (IV) infusion of mesenchymal stem cells (MSCs) promotes recovery after SCI. Ho...

Mass univariate aggregation methods for machine learning in neuroscience

Machine learning is a ubiquitous part of the modern neuroimaging toolkit, particularly for research aimed towards precision medicine goals of improving individual-level diagnosis and treatment. However, the high dimensionality of neuroimaging data poses significant challenges for...

Detectability of Forced ENSO Changes Under Global Warming: Insights From the Recharge Oscillator

Abstract We use perfect‐model, large‐ensemble nonlinear Recharge Oscillator (RO) simulations to quantify ENSO internal variability and the detectability of forced changes in ENSO characteristics. Fixed‐parameter simulations show that linear trends in ENSO standard deviation, peri...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

What would the neoliberalization of Nordic industrial relations look like?

This article addresses a set of broadly theoretical issues concerning how neoliberalization should be conceptualized in Nordic industrial relations. The first issue is the appropriate metrics of neoliberalization in industrial relations in the Nordics. The article argues that neo...

Loneliness, not isolation, is the missing link between social connectedness and mental health among midlife to older U.S. adults

Objectives To investigate whether loneliness or social isolation serves as the main pathway connecting social connectedness dimensions to mental health outcomes among midlife to older adults.Methods We examined longitudinal data from 4,963 adults aged 40–65 at baseline in the U.S...

Generation, differentiation, and potential of three radial glial subtypes in human cortical organoids

Radial glia are the principal neural stem cells in the developing human cerebral cortex and have been classified as three molecularly distinct subtypes: ventricular radial glia (vRG), outer radial glia (oRG), and truncated radial glia (tRG). Human cortical organoids (hCOs) from h...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT

Abstract Metabolism is fundamental to cell function, yet its activities vary across tissue environments. Resolving these processes in situ at single-cell resolution is crucial for understanding physiology in health and disease. However, existing methods lack biochemical specifici...

Episodic super-Eddington accretion as a clue to Overmassive Black Holes in the early Universe

Abstract Early JWST observations are providing growing evidence for a ubiquitous population of accreting supermassive black holes (BHs) at high redshift, many of which appear overmassive compared to the empirically-derived local scaling relation between black hole mass and host g...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

Molecular mechanisms governing the action of the epidermal growth factor receptor and receptor tyrosine kinases, a personal perspective

I have been studying the mechanism of action of epidermal growth factor (EGF) receptor (EGFR), other receptor tyrosine kinases (RTKs) and their cellular signalling pathways for the past 45 years. A decade ago, I authored a review detailing the first two decades of research and hi...

Perceptions of surrogate decision-makers of cardiac arrest patients on engaging in research during high emotional distress

The perception that individuals in crisis experience undue psychological burden by participation in research is a barrier to including surrogate decision-makers to critically ill patients in research studies. Importantly, perceptions from those who have engaged as surrogates are...

Emotional interactive experiences in different environments and cultures: machine learning-based electrocardiogram analysis of the emotional elicitation effect in augmented reality

Emotions are dynamic feedback mechanisms by which individuals respond to external stimuli, and the environment profoundly influences their changes. Therefore, it is necessary to incorporate healing and inclusive considerations into public environmental design. This study combines...

Testing Complementarity Between Reflective Practice and Self‐Reflection in Professional Identity Formation

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Impact of ethyl alcohol nasal treatment on hospital-onset Staphylococcus aureus bacteremia at a tertiary health system

Abstract Introduction: Staphylococcus aureus is a common pathogen that can cause nosocomial infection. Ethyl alcohol has emerged as a potential alternative to mupirocin and povidone-iodine for nasal decolonization; however, data on real-world application are limited. Methods: A q...