Yale University

L-ICON3 Suppresses Endometriosis in a Murine Model

Endometriosis is a chronic, systemic gynecological disorder that affects 190 million women worldwide. Current treatments consist of hormonal suppression and surgical excision; however, both have considerable side effects and a high risk of recurrence. Here, we report a systemic t...

What Survivors Remembered: Cognitive and Experiential Themes in Trauma Narratives From the Deadliest Mass Shooting in Modern American History

This study examined cognitive and experiential patterns in the trauma narratives of 42 survivors (74% women; M age = 42.1) of the Route 91 Harvest Festival shooting, the deadliest mass shooting in modern American history. We conducted a codebook thematic analysis of written narra...

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

Abstract The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC...

Pediatric Hospital Medicine Board-Certified and Non–Board-Certified Hospitalists Are Welcome Here

The Consortium of Pediatric Hospital Medicine, representing elected leaders in the field of Pediatric Hospital Medicine (PHM), proudly welcomes and fully supports every pediatric hospitalist, sub-board certified and non–sub-board certified alike, as integral contributors to our c...

The role of chloride ions in serotonin transport

Abstract The human serotonin (5-HT + ) transporter SERT facilitates 5-HT + transport into cells by coupling it to Na + symport and K + antiport. Although extracellular Cl − is also essential for transport, Cl − co-transport has been disputed, raising questions about the role of C...

A cumulative cold dosimetry model for cryoablation: from geometry to dose-time planning

Abstract Purpose To propose a cumulative cold dose (CCD) model integrating spatial, temporal, and biological dosimetry for cryoablation protocol optimization. Methods Systematic searches identified studies reporting freeze duration effects, cell-type-specific lethal thresholds, l...

Structured Debriefing After Adult ICU Intubation: A Narrative Review and Implementation Framework

BACKGROUND: Endotracheal intubation in the intensive care unit (ICU) carries substantial risk, with adverse events such as hypoxia and hemodynamic instability occurring in up to 40% of critically ill patients. These events affect not only patient safety but also team learning and...

Clinical Boundaries of Trauma

AIM: Post-traumatic stress disorder (PTSD) rarely occurs in isolation; over 80% of individuals present with comorbid conditions such as depression, anxiety, or substance use disorders. The polythetic DSM-5 structure creates substantial diagnostic heterogeneity, producing thousand...

Self-rankings as a predictor of scientific impact beyond peer review

Abstract Peer review in academic research aims to ensure factual correctness and identify work of high scientific potential, but rapid submission growth has made this increasingly difficult. Here we investigate an additional measure for identifying high-impact research: authors’...

Platelet-derived S100A9 contributes to endotheliopathy in alcohol-associated hepatitis

Alcohol-associated liver disease (ALD) is a growing global health concern, with alcohol-associated hepatitis (AH) leading to the highest morbidity and mortality. Available therapies are limited and often inadequate. Platelets contribute in a variety of ways to liver disease patho...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

Multisoliton Solutions and Blow Up for the $$L^2$$-Critical Hartree Equation

Abstract We construct multisoliton solutions for the $$L^2$$ L 2 -critical Hartree equation with trajectories asymptotically obeying a many-body law for an inverse square potential. More precisely, we consider the m -body hyperbolic and parabolic non-trapped dynamics. The pseudo-...

Cardiometabolic Benefits and Risks for Transgender Youth with the Initiation of Gender-Affirming Hormone Therapy: a case series

Background. Interventions for transgender youth include puberty suppression and gender affirming hormone therapy (GAHT). Studies have begun to show changes in cardiometabolic outcomes in adolescent transgender males (TGM) and females (TGF). We hypothesized that in TGM and TGF you...

Management coverage and spatial gaps for carnivore habitat across Mexico

Abstract Area‐based conservation is central to global wildlife protection. In Mexico, a mosaic of land management types beyond traditional protected areas (PAs), including voluntary conservation areas (VCAs), wildlife management units (UMAs), and Indigenous Territories (ITs), may...

HIPPIE: a generative model for electrophysiological analysis across species, technologies, and modalities

Abstract Neuronal classification from extracellular electrophysiological recordings is challenging due to intrinsic waveform variability, noise, and technical differences across experiments, technologies, and species. We introduce HIPPIE (High-dimensional Interpretation of Physio...

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Abstract Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to...

Structural causal influence captures the forces of social inequality in models of infectious disease

Abstract Mathematical models are central to understanding disease transmission for host–pathogen systems across the biosphere. However, most existing frameworks do not explicitly treat host population heterogeneity as a formal driver of variation in transmission dynamics. This ga...

Thoracic ligamentum flavum ossification causing progressive myelopathy: a case report

Background: Ossified ligamentum flavum (OLF) in the thoracic segments is a rare but significant cause of progressive myelopathy characterized by spinal canal stenosis. While OLF is commonly reported in East Asian populations, it remains under-recognized in other regions, includin...

Time-dependent divergence in infection risks among patients with multiple sclerosis treated with fumarates versus anti-CD20 monoclonal antibodies

Background: People with multiple sclerosis (pwMS) treated with anti-CD20 monoclonal antibodies have an elevated infection risk, yet long-term comparative data with oral fumarates are limited. Objective: To compare infection incidence, healthcare resource utilization, and relapse...

Optimizing culture-free approaches to recover high-quality Mycobacterium tuberculosis genomic variation

Background. Mycobacterium tuberculosis ( Mtb ) genomic epidemiology often relies on culturing patient sputum, a time- and labour-intensive process. Hybrid capture approaches have been successfully used to enrich Mtb DNA from complex clinical samples, yet the accuracy of variant i...