Yale University

Fire as a productive and preventive technology: traditional knowledge and risk governance in Kalunga agropastoral mosaics

Abstract Background Savanna landscapes have returned to the centre of socio-environmental debate as climate variability, agricultural expansion, and prohibition-oriented policies reshape how fire is understood and governed. Focusing on Brazil’s largest maroon (quilombola) territo...

Nickel(I) in an All-FerricNiFeS Cluster

Abstract Anaerobic carbon monoxide dehydrogenase (CODH) enzymes interconvert CO2 and CO under mild conditions and with near perfect selectivity. The CODH active site, termed the C-cluster, is a [NiFe3S4]-Feu cluster that can reside in several different oxidation states. Despite d...

An entangling gate for dual-rail erasure qubits

Quantum error correction (QEC) will likely be required to realize the full potential of quantum computing, but comes with daunting hardware overheads and demands low gate errors on the physical qubits1–4. These requirements can be eased by engineering qubits with a strong error h...

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata , is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...

Two cases of pregnancy during the fourth year of 68 mg etonogestrel implant use

PURPOSE: The United States Food and Drug Administration recently expanded approval of the 68 mg radiopaque etonogestrel (ENG) contraceptive implant (Nexplanon, Organon, Oss, The Netherlands) from three years to five years, based on clinical trial data showing no pregnancies in ye...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

Continuous Glucose Monitoring for Persons With and Without Diabetes

This JAMA Internal Medicine Patient Page describes use of continuous glucose monitors, as well as their benefits and drawbacks.

Uncertainty and Ethical Permissibility in Youth Gender Care

This Viewpoint discusses how misuse of evidence-based medicine displaces the pediatric ethical principles of proportionality and shared decision-making and risks precluding both access to care and generation of evidence needed to reduce uncertainty.

How Does Receipt of Dementia Screening Impact Depressive Symptoms Among Patients and Their Family Members?

BACKGROUND: The impact of dementia screening on the mental health of older adults and their family members remains insufficiently understood, particularly in light of the bidirectional dynamics within the older adult-family dyad. This study aims to examine how dementia screening...

Precision Custom-Guided Anteromedial Tibial Tubercle Transfer Surgery

Recurrent lateral patella instability is primarily a result of lateral patella entry to the femoral trochlea. Using 3-D imaging, one can accurately assess this lateral entry more accurately than with plain radiographs, making 3-D imaging important for optimal surgical planning, p...

A foundation model for sleep-based risk stratification and clinical outcomes

Abstract Clinical sleep studies capture multiple physiologic signals, yet interpretation is often reduced to single summary measures of limited prognostic value, such as the apnea–hypopnea index. We present a foundation model that learns rich representations of sleep physiology f...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

Building Climate-Resilient Mediterranean Olive Systems: Integrating Soil, Water, Carbon, Biodiversity, and Innovation for a Sustainable Future

Abstract Mediterranean olive systems face compound climatic, ecological, and socio-economic pressures. Drawing on the consensus of the International Conference on Sustainability in Olive Cultivation (ICSOC) 2025, we propose an integrated framework structured along three axes: fiv...

L2K-ARG

Abstract The present study introduces an open-access corpus of Korean second language argumentative writing (L2K-ARG) produced by university-level learners with different first-language backgrounds. The corpus contains 484 essays written in response to three standardized prompts...

Context-sensitivity and longitudinal stability of the effects of depressive symptoms on social and reward decision-making

Depressive symptoms could affect decision-making in multiple ways, yet it remains unclear whether these effects are context-sensitive or stable over time. In this longitudinal study, 236 online participants (n=129 at 1-month follow-up) completed a social exchange task (Ultimatum...