Yale University

Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development

Abstract Childhood adversity is a potent predictor of mental health problems across the lifespan, and a rich cross-species literature implicates stress-sensitive corticolimbic circuits in adversity-related psychopathology. Structure-function coupling (SFC) is a promising multimod...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

Modern endoscopic strategies for the diagnosis and management of cholangiocarcinoma

Cholangiocarcinoma (CCA) presents considerable diagnostic and therapeutic challenges for the endoscopist. This review offers a focused and practical evaluation of contemporary endoscopic approaches for the diagnosis and management of CCA, with an emphasis on real-world applicabil...

The Case for a Gap between Verdict and Sentencing at Court-Martial

Abstract The military is the only American jurisdiction that nearly always proceeds immediately from a verdict of guilt to the imposition of punishment. This compressed timeline produces a self-reinforcing dynamic: Because counsel lack the time to develop detailed factual records...

Quantifying the Burden of Cerebellar and Ophthalmologic Disease in Lambdoid Craniosynostosis

OBJECTIVE: Lambdoid craniosynostosis may restrict posterior brain development, particularly involving the cerebellum and occipital lobe, with potential implications for vision and balance. However, due to its rarity, evidence linking lambdoid craniosynostosis to adverse ophthalmo...

Rare variant effect estimation and polygenic risk prediction

Abstract Due to their low frequency, estimating the effect of rare variants is challenging. Here, we propose RareEffect, a method that first estimates gene- or region-based heritability and then each variant effect size using an empirical Bayes approach. Our method uses a varianc...

Trait Plasticity in Herbivore Populations Maintains Geographic Patterns of Herbivory on a Dominant Plant Species Under Warming

ABSTRACT Across species' geographic ranges, local populations may enlist behavioral, physiological, and morphological plasticity together to cope with stress from changing thermal conditions. But if local populations cannot sufficiently adjust their phenotype, then they may fail...

DOSE: An open-source, iOS watch-based tool for experience sampling

Smartwatches facilitate low-burden rapid-access micro-interactions, making them ideal for Experience Sampling Methods (ESMs). Despite the Apple Watch being the most popular smartwatch in the U.S., it has yet to be utilized in ESM studies due to a lack of accessible frameworks tha...

Beyond Immediate Responses: A Systems Map of Community Factors Underlying Persistent Gun Violence in New Haven

Abstract Gun violence is a pervasive and multifaceted public health problem. This study describes a novel application of group model building—a process that centers stakeholder voices to describe a complex problem—to investigate drivers of gun violence and design community-led in...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Toward federated large language models in medicine: a parameter-efficient framework for privacy-preserving, multi-institutional adaptation

Large language models (LLMs) are increasingly adapted for medical applications, but most are trained using data from a single institution because privacy and governance constraints prevent multi-institutional data sharing. As a result, these models often generalize poorly across...

RobustCell: a model attack-defense framework for robust transcriptomic data analysis

Abstract Computational methods should be accurate and robust for tasks in biology and medicine, especially when facing different types of attacks, defined as perturbations of benign data that can cause a significant drop in method performance. Therefore, there is a need for robus...

Estimating genetic correlation jointly using individual-level and summary-level GWAS data

Abstract With the increasing accessibility of individual-level data from genome wide association studies, it is now common for researchers to have individual-level data of some traits in one specific population. For some traits, we can only access public released summary-level da...

From Policy to Practice: A Statewide Model to Expand School-Community Mental Health Partnerships

Abstract Schools are a primary access point for youth mental health services, yet most lack the sustained funding, infrastructure, and partnerships needed to build comprehensive and equitable systems of care. State policy offers a mechanism to address these limitations, but there...

Data-driven prediction of fifteen-year all-cause mortality among 2.3 million individuals in the VA

ABSTRACT We present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most comm...

Electroreduction of Activated Esters Catalyzed bya Manganese Complex

Abstract Electrochemical hydrogenation (electrohydrogenation) using electrons and protons as H2 surrogates offers a sustainable alternative to conventional reduction methods. Herein, we report the manganese-catalyzed electroreduction of activated esters employing a derivative of...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Review of the Acute Interstitial Nephritis (AIN) Risk calculator

The AIN risk calculator was developed to improve non-invasive diagnostic accuracy for acute interstitial nephritis, an asymptomatic and often poorly recognized but potentially reversible cause of acute kidney injury. The equation was developed in a cohort of adult patients who un...

Fatigue after ischaemic stroke: A five-year longitudinal study of prevalence and latent trajectory subgroups

Objective To investigate the prevalence and longitudinal course of post-stroke fatigue and identify subgroups with distinct fatigue trajectories up to 5 years post-stroke. Design A prospective, longitudinal, multi-centre cohort study. Setting Hospital stroke units in the Central-...

DOPAL links dopamine dysregulation to neurodegeneration: a translational systematic review and meta-analysis

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the most reactive dopamine (DA)-derived aldehyde and has been implicated in selective dopaminergic neurodegeneration in α-synucleinopathies, including Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we present the first...