Wenzhou Medical University

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...

Imaging Manifestations and Clinical Analysis of 12 Cases of Anorectal Malignant Melanoma

AIM: To investigate the computed tomography (CT) and magnetic resonance imaging (MRI) features and clinical characteristics of primary anorectal malignant melanoma (ARMM).METHODS: This retrospective analysis was conducted on the clinical, imaging and pathological data of 12 patie...

Joint trajectories and associated characteristics of postpartum depressive and anxiety symptoms: a longitudinal study

Postpartum depressive and anxiety symptoms are common postpartum mental health issues, and these symptoms often co-occur. However, previous studies have primarily analyzed them separately, with limited evidence regarding their joint developmental trajectories and associated chara...

Association Between Preoperative Tea Drinking Habits and Postoperative Ileus in Colorectal Cancer Patients: A Propensity Score-Matched Study

Objective This study evaluated whether preoperative tea consumption reduces postoperative ileus risk after colorectal cancer surgery, given tea’s anti-inflammatory and antioxidant properties. Methods In this retrospective cohort of 681 patients, tea drinkers (≥1 cup/day, n = 191)...

CD147+ Cancer‐Associated Fibroblasts Promote PD‐L1 Expression in Hepatocellular Carcinoma via TIMP2/MMP2/IL‐6 Signaling

BACKGROUND: Targeting CD147 on hepatocellular carcinoma (HCC) cells has demonstrated therapeutic efficacy. Cancer-associated fibroblasts (CAFs) have been identified as critical components of the tumor microenvironment. The role of CD147 in CAFs is still unclear, and this study ai...

Agarose-Encapsulated Multifunctional Microspheres with High Drug Payload and Multimodal Imaging Capability for Arterial Embolization–Associated Hyperthermia Therapy

Hepatocellular carcinoma (HCC) represents a leading cause of cancer-related mortality worldwide, and transarterial chemoembolization (TACE) remains the standard first-line locoregional therapy for intermediate-stage HCC. Nevertheless, conventional TACE frequently yields suboptima...

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O ‐GlcNAcylation‐Induced m6A Demethylation of HRAS

ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is driven by nutrient stress through incompletely defined epigenetic mechanisms. This study demonstrates that lipid stress activates the hexosamine biosynthesis pathway (HBP), elevating O ‐linked β‐N‐acetylglucosami...

Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury

Oral nano-biohybrid therapeutics provide opportunities for gut–organ axis intervention, but gastrointestinal transit often compromises both probiotic viability and nanozyme activity. Here, we developed CeO 2 @LP@EL, an enteric-gated nano–probiotic living nanozyme constructed by d...

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

ABSTRACT Postmenopausal osteoporosis is caused by excessive osteoclast‐mediated bone resorption. This study identifies mitochondrial oxidative phosphorylation (OXPHOS) as a tractable metabolic target for antiresorptive therapy. A literature‐guided drug repurposing screen focused...

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

ABSTRACT Dry eye disease (DED), a chronic disorder affecting nearly half the global population, is perpetuated by oxidative stress, inflammation, and tear film instability. Constrained by short precorneal residence and monotherapy, DED therapies necessitate frequent dosing and po...

Prognostic biomarkers in non‐muscle‐invasive bladder cancer: biological basis and evidence

Objectives To review prognostic and treatment‐response biomarkers for non‐muscle‐invasive bladder cancer (NMIBC), with particular attention to biological function, specimen type, assay method, statistical evidence, and possible clinical use. Methods We conducted a focused narrati...

Performance of the axial length-to-corneal radius ratio in distinguishing pre-myopia from hyperopia under cycloplegia in school-aged children: an age-stratified retrospective cross-sectional study

The axial length/corneal radius (AL/CR) ratio is an established structural indicator of myopia, but its ability to discriminate within the non-myopic range—specifically pre-myopia from hyperopia under cycloplegia—remains poorly characterised. We aimed to evaluate the performance...

Remote‐Controlled Genetic Circuits: Light, Ultrasound, and Magnetic Fields for Programmable Gene Regulation

Remote-controlled genetic circuits use externally applied physical signals to regulate gene expression and cellular functions with spatial and temporal precision. Light, ultrasound, and magnetic fields provide complementary advantages in controllability, tissue accessibility, and...

Coniferaldehyde Reverses PGK1–3-Phosphoglycerate–L-Serine Metabolic Reprogramming in Hindlimb Ischemia

Background/Objectives: Ischemic skeletal muscle undergoes metabolic remodeling that may influence vascular repair. We investigated whether coniferaldehyde (CA) regulates a phosphoglycerate kinase 1 (PGK1)–3-phosphoglycerate (3PG)–L-serine axis in mouse hindlimb ischemia (HLI). Me...

VesselRegNet: Multi-Scale Feature Fusion Network for Multi-Modal Joint Retinal Vessel Segmentation and Registration

Multimodal retinal image registration remains challenging due to nonlinear intensity discrepancies and insufficient feature representation across modalities. To address these limitations, we propose VesselRegNet, a joint retinal vessel segmentation and registration framework base...

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

Mode‐Selective C═C and C─N Vibrational Coupling Modulates Nonradiative Decay in Regioisomeric Organic Phosphorescent Emission

ABSTRACT Structural isomerization has emerged as an effective strategy for improving the performance of organic room‐temperature phosphorescent materials, but reported explanations are mainly attributed to differences in molecular packing, spin‐orbit coupling, excited‐state elect...

A DNA Nanoplatform with Rolling Circle-DNAzyme Feedback Programming for Autonomous Exponential Amplification Enables Multiplexed Orthogonal miRNA Profiling toward Precise Diagnosis of Bladder Cancer

Abstract Simultaneous and sensitive detection of multiple microRNAs in complex biological and clinical serum samples is critical for early and accurate bladder cancer (BC) diagnosis. Here, by integrating I-R3-mediated self-cleavage-coupled feedback amplification into three indepe...

Invasive Pneumococcal Disease in Children: A Retrospective Three-Center Study in Zhejiang Province, China (2010–2024)

Invasive pneumococcal diseases (IPD) are among the leading causes of global child mortality. Pneumococcal conjugate vaccines provide direct protection against IPD caused by serotypes included in the vaccine. To investigate the clinical characteristics, serotypes, and antibiotic r...