University of Zurich

Impact of Structured Data Validation on Case Completeness and Key Quality Indicators in the SWISS Implant Registry (SIRIS Spine): A SINGLE-CENTER Audit

Study design Retrospective single-center registry validation audit. Objective To quantify the impact of semi-automated, chart-adjudicated data validation workflow on case completeness and key quality indicators in the Swiss Implant Registry (SIRIS Spine). Methods All Swiss proced...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

The Association Between Chronic High-Altitude Exposure and Increased Pulmonary Vascular Resistance in Healthy High-Altitude Residents: A Systematic Review and Meta-Analysis

00:00-00, 2026. BACKGROUND: At high altitude, hypoxia triggers pulmonary vasoconstriction and vascular remodeling, potentially elevating pulmonary vascular resistance (PVR). Whether chronic high-altitude exposure raises PVR to clinically meaningful levels remain unclear, particul...

Resolving circumarctic zero-curtain phenomena with AI-integrated earth observations

<title>Abstract</title> Across the circumarctic, permafrost landscapes store approximately 1700 billion metric tons of organic carbon - nearly twice atmospheric levels - yet reservoir stability depends on the zero-curtain, a subsurface thermal plateau that emerges when latent hea...

Ketamine’s impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial

Abstract Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence these dynamics via glutamatergic mechanisms. In a ran...

Does increased staging complexity influence expert agreement in dental age estimation?

Dental age estimation (DAE) is a well-established procedure in current practice, and it is frequently required in forensic and legal investigations. This study aimed to evaluate the intra- and inter-observer reliability of dental development staging among forensic practitioners u...

Brassinosteroid-regulated transcription factors confer epigenetic changes that repress plant immunity

Abstract When organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they often also incur trade-offs, such as reduced growth and development and must therefore be tightly controlled 1,2 . In this...

More than just green: the role of vegetation heterogeneity for species richness and multidiversity in urban green spaces

<title>Abstract</title> Urban green spaces (UGS) provide ecological, social, and climatic functions, yet their effectiveness depends not only on area but also on vertical spatial structure. We present a high-resolution urban green space typology (UGST) for four Swiss cities (Base...

Task-irrelevant stimuli robustly drive phasic pupil-linked arousal but only weakly affect memory formation

Abstract Brainstem arousal systems including the locus coeruleus noradrenaline system, respond transiently to behaviorally relevant events. This also drives dilations of the pupil, which are often observed during cognitive tasks. The strength of pupil responses during encoding of...

Unveiling centromeric retrotransposon dynamics through a high-quality rye genome assembly

Abstract Rye ( Secale cereale L.) is an important cereal crop known for its high yield potential and tolerance to biotic and abiotic stresses. However, its large, repeat-rich, and heterozygous genome has posed challenges for assembly compared to related species such as wheat and...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

A cross-cultural survey of Indigenous views on interspecies communication – Towards a consilience with scientific knowledge

Communication serves as a pivotal means for mutual understanding beyond species boundaries. Definitions of interspecific communication – particularly between humans and non-human organisms – vary not only across research disciplines, but also across cultures and societies driven...

Congenital cervical pathologies in the saber-toothed cat Smilodon fatalis and the cave bear Ursus spelaeus – Nearing extinction in Late Pleistocene times

Inbreeding is a known cause for an increased incidence of vertebral malformations. Inbreeding can be the result of geographical isolation of a diminishing wild population. A high incidence of transitional vertebrae has for example been reported in declining, inbred populations of...

Congenital cervical pathologies in the saber-toothed cat Smilodon fatalis and the cave bear Ursus spelaeus – Nearing extinction in Late Pleistocene times

Inbreeding is a known cause for an increased incidence of vertebral malformations. Inbreeding can be the result of geographical isolation of a diminishing wild population. A high incidence of transitional vertebrae has for example been reported in declining, inbred populations of...

Phylogenetic structure of conifers in regional floras in relation to climate and environmental heterogeneity worldwide

Despite having only about 670 species worldwide, conifers are one of the ecologically and economically most important plant groups. They have a rich fossil record and previous studies have shown that their current diversity is the result of past radiations, extinction, and disper...

Prospective annual evaluation of sports motor performance, BMI and social index in Swiss first graders over a period of 12 years

Abstract Understanding factors that influence children’s motor development is of major public health relevance, given its association with physical activity, health trajectories, and long-term well-being. This study evaluates neuromotor development alongside environmental factors...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Chestnut (Castanea sativa Mill.) leaf extract and pure castalagin reduce bacterial colonisation and the associated inflammation in gastric organoids and a mouse model of H. pylori infection

BACKGROUND: Helicobacter pylori is a bacterium that has been identified as a causative agent in the development of chronic gastritis, peptic ulcers, and gastric cancer. Current eradication therapies, based on antibiotic combination, are suffering from lack of patient compliance a...

Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1

Abstract METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimi...