University of Zurich

Next-generation forensic 3D surface documentation with projection-assisted digital spray multicamera photogrammetry and 3D gaussian splatting

Abstract Accurate injury documentation is essential in forensic medicine, however conventional two-dimensional imaging methods are limited in their ability to capture spatial morphology and enable retrospective three-dimensional (3D) reassessment. Although multicamera photogramme...

Transcriptomic signatures of hydroxyurea response in sickle cell disease

Abstract Background Hydroxyurea (HU) has been widely used as a first-line therapy for sickle cell disease (SCD), an autosomal recessive monogenic disorder characterized by abnormal haemoglobin and chronic haemolysis. However, its multiple mechanisms of action, particularly those...

Understanding implementation patterns of the FICUS family support intervention: a matrixed multiple case study across Swiss adult intensive care units

Abstract Background Variations in implementation success across sites are common when introducing complex health interventions; however, such variations are rarely examined systematically, particularly for family-focused interventions in intensive care units (ICUs). As part of a...

Reconstructing the molecular epidemiology of rabies in Switzerland from outbreak to elimination (1967–1997)

Abstract Rabies virus (RABV) is a lethal zoonotic pathogen that remains endemic in some parts of the world despite long-standing vaccination efforts. We present a comprehensive genomic and evolutionary analysis of the sylvatic rabies epidemic in Switzerland (1967–1997) and propos...

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression

Abstract Current immunotherapies often fail in immunologically “cold”, macrophage-rich tumor microenvironments (TMEs). Multi-targeting approaches that modulate innate-adaptive immune activation represent a promising frontier in cancer immunotherapy. Here, we developed phagocytic...

‘Controlled culling is essential for sustainable zoo populations’

Marcus Clauss and João Pedro Meireles argue that society accepts different forms of animal management in different contexts, yet often judges zoos by a different standard.

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Subsite-specific prediction of lymphatic spread in head-and-neck cancer using a mixture of hidden Markov models

Abstract Head-and-neck squamous cell carcinomas (HNSCC) metastasize to neck lymph nodes. Radiation treatments include the elective irradiation of lymph node levels (LNLs) at risk of harboring occult (clinically undetected) metastases. We present a statistical model for personaliz...

Blue-throated macaws ( Ara glaucogularis ) copy conspecifics in bidirectional control tasks

Abstract Copying via imitation (replicating others’ bodily actions) or emulation (replicating others’ action goals) underpins the cultural transmission of social norms and technical skills in humans. Many non-human animals, ranging from mammals to reptiles, have also been observe...

Self-regulatory strategy use in exam preparation: reflection and automaticity shape successful self-regulation

In a preregistered reanalysis of two longitudinal studies (N = 200, N = 294), we examined students’ self-regulation during exam preparation. Assessments included a baseline, twice-weekly measures over two weeks, a fourth-week questionnaire, and (in Study 2) a follow-up on exam gr...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

Autologous hematopoietic stem cell transplantation stabilizes retinal atrophy in multiple sclerosis

Abstract Autologous hematopoietic stem cell transplantation (aHSCT) is an effective treatment for aggressive multiple sclerosis refractory to disease-modifying therapies. Yet, its impact on neurodegeneration remains underexplored, and few predictive biomarkers for clinical outcom...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Assessing the agreement and reliability of Magene ® for heart rate monitoring

To evaluate the accuracy and reliability of the Magene ® heart rate (HR) monitor compared to the Polar ® H7 (validated device) during rest, maximal graded exercise test, and active recovery. A within-group study was conducted with 68 healthy adults (21 women). Participants comple...

Improving image quality by reducing breathing artifacts in CT of patients early after coronary artery bypass graft surgery

Abstract The purpose of this study was to evaluate whether a misalignment correction algorithm reduces artifacts from breathing in patients undergoing computed tomography angiography (CTA) early after coronary artery bypass graft (CABG) surgery. In this retrospective study, conse...

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Importance: Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective: To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in pat...

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...

Early definitive fracture fixation (EDFF) does not alter circulatory neutrophil activation status in physiologically restored polytrauma: a 72-h porcine observation study

Abstract Dysregulation of the cellular innate immune system, particularly involving leukocytes and mainly neutrophils, underlies post-traumatic inflammatory complications. Early definitive fracture fixation (EDFF) triggers immune activation and may exacerbate inflammatory complic...

Defying Distance? The Provision of Medical Services in the Digital Age

Digital platforms reduce geographic frictions, enabling better matching between service providers and users. I quantify reallocation gains in Swedish online health care, using nationwide time-conditional random assignment between patients and physicians. Matching high-risk patien...