University of Zurich

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross‐Sectional Study

OBJECTIVES: To delineate the craniofacial morphometric characteristics of Thai children with syndromic (SC) and non-syndromic craniosynostosis (NSC) and to assess dental maturation relative to Chronological Age (CA). METHODS: This comparative cross-sectional study evaluated 19 pa...

Effect of air-borne particle abrasion and tribochemical silica coating on surface characteristics, mechanical behavior, and bonding performance of 3D-printed resin-based materials

Abstract Objectives This study evaluated how air-abrasion material, application time, and aging affect the surface characteristics, mechanical behavior, and bonding performance of three-dimensionally (3D) printed resin. Methods Specimens were treated with aluminum oxide (Al₂O₃) o...

Vegetation-driven shifts in soil microbial communities and predicted carbon-cycling potential across soil depths in High-Arctic islands

Abstract Background Arctic ecosystems are experiencing unprecedented warming, driving vegetation expansion into previously barren areas. Although Arctic greening is expected to alter biogeochemical cycles, how vegetation cover shapes soil microbial communities and their functiona...

Industry partnerships

Overview of industry programs to support translational life science research in academia (& start-ups)

An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis

Oral squamous cell carcinoma (OSCC) remains the most common oral malignancy and has limited targeted therapeutic options. Specificity protein 1 (Sp1), a versatile zinc-finger transcription factor, has emerged as a pivotal regulator of cellular proliferation, apoptosis, epithelial...

Uncertainty-Aware Modeling in Integrated Epithelial Transport Networks

While computational mechanistic models can provide insight into the coupled transport of substrates through complex networks of membrane transporters and channels, commonly used deterministic models are often constrained by uncertainty in model structure and in parameters derived...

Hospital-Level Determinants of Mortality After Pancreas Surgery

OBJECTIVE: To identify modifiable hospital-level determinants of mortality after pancreas surgery and assess their cumulative protective effects through the development of a Hospital Resource Index (HRI) on a global scale. BACKGROUND: Ninety-day mortality rates after pancreas sur...

Biofeedback‐Based Therapy in Patients With Myofascial Orofacial Pain and Bruxism: An Umbrella Review

BACKGROUND: Biofeedback therapy is increasingly used to manage myofascial orofacial pain and bruxism, but the overall strength and consistency of the evidence remain unclear. OBJECTIVES: This umbrella review aimed to synthesize and critically evaluate evidence from systematic rev...

Advancing conflict research and response through satellite-derived data

Abstract With armed conflicts at a historic high and attacks on civilians rising 1 , understanding the evolving nature of conflict is a critical research priority. The current paradigm in conflict research relies heavily on text-based data, using fatalities as the primary—and oft...

Performance of point‐of‐care tests for diagnosing feline immunodeficiency virus infection in captive African lions ( Panthera leo )

Point-of-care (PoC) antibody (Ab) testing forms an integral component of feline immunodeficiency virus (FIV) diagnosis in both domestic and non-domestic felids, with test kits designed for use in domestic cats frequently extrapolated for use in their wild counterparts. The SNAP®...

Multimodal protective and susceptibility clusters in paediatric atopic dermatitis: A machine learning-based, data-driven observational study

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease that typically develops in early childhood. Differences in AD prevalence and allergy sensitisation patterns have been observed in African populations, including the AmaXhosa population in South Africa, sugge...

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

OBJECTIVE: To identify the specific gastrointestinal (GI) symptoms associated with clinically relevant fatigue in systemic sclerosis (SSc), beyond the established association between overall GI involvement and fatigue. METHODS: We conducted a cross-sectional study including conse...

Industry partnerships

Overview of industry programs to support translational life science research in academia (& start-ups)

The UZH protocol: Separating errors and constructing improved CP2K basis sets and pseudopotentials

Reliable density-functional simulations require numerical settings whose residual errors are smaller than the chemical and materials trends being interpreted. In CP2K/QUICKSTEP, this requirement is complicated by the joint use of atom-centered Gaussian basis sets and norm-conserv...

Genomic insights into the evolutionary dynamics of Phytophthora infestans lineages after the Irish Potato Famine

Abstract Background Genomic analysis of infected herbarium specimens provides the opportunity to investigate the evolutionary history of plant pathogens, leading to discoveries such as the identification of FAM-1/HERB-1 as the Phytophthora infestans lineage that caused the ninete...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

The epigenome of the postnatal male germline: A double-edged sword between flexibility and stability

Abstract Epigenetic regulation is central to cell development and functions in multicellular organisms. In the male gonads of mice, it contributes to the control of spermatogenesis, the process of spermatozoa production by differentiation of spermatogonial stem cells (SSCs) and s...

BCA ADEMP-PreReg

Completed ADEMP-PreReg (Siepe et al. 2024) pre-registration plan for a simulation study included in the revision of the paper on Bayesian conjugate analysis by Degen, Pawel, and Held.

Structural Elucidation and Revised Biosynthetic Pathway of the Membrane Vesicle–Associated Antifungal Compound AFC-BC11

Abstract Bacterial membrane vesicles (MVs) serve as delivery vehicles for hydrophobic and membrane-associated secondary metabolites, enhancing their solubility, stability, and bioactivity. Here, we show that the antifungal compound AFC-BC11, produced by Burkholderia cenocepacia K...