University of Zurich

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Prospective annual evaluation of sports motor performance, BMI and social index in Swiss first graders over a period of 12 years

Abstract Understanding factors that influence children’s motor development is of major public health relevance, given its association with physical activity, health trajectories, and long-term well-being. This study evaluates neuromotor development alongside environmental factors...

Mammography-Based Radiomics for Prediction of Nodal Status and Disease Burden in Breast Cancer: A Temporally Validated Study

Objectives: We evaluated the performance of mammography-based radiomics in prediction of clinical nodal status, clinical tumor stage, clinical disease stage, status of the PIK3CA mutation and concordance with the radiologist-assessed BI-RADS category. Mammography is often the fir...

The single cell transcriptional signature of sexual commitment in the human malaria parasite Plasmodium falciparum

<ns5:p> Background Malaria remains a global health challenge, with most fatal cases caused by <ns5:italic>Plasmodium falciparum</ns5:italic> in sub-Saharan Africa. A critical bottleneck in the <ns5:italic>Plasmodium</ns5:italic> life cycle is the transmission from human to mosqui...

Impermanent Loss Conditions: An Analysis of Decentralized Exchange Platforms

Decentralized exchanges are widely-used platforms for trading cryptoassets. The most fundamental and openly-accessible type of decentralized exchange is based on automated market makers (AMMs), where traders transact against asset reserves managed by smart contracts. These assets...

Chestnut (Castanea sativa Mill.) leaf extract and pure castalagin reduce bacterial colonisation and the associated inflammation in gastric organoids and a mouse model of H. pylori infection

BACKGROUND: Helicobacter pylori is a bacterium that has been identified as a causative agent in the development of chronic gastritis, peptic ulcers, and gastric cancer. Current eradication therapies, based on antibiotic combination, are suffering from lack of patient compliance a...

Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1

Abstract METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimi...

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti-infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseas...

Evaluating plasma renin activity as a monitoring parameter for mineralocorticoid treatment in dogs with primary hypoadrenocorticism

Abstract Background In human medicine, plasma renin activity (PRA) is used to assess mineralocorticoid treatment adequacy in hypoadrenocorticism, with elevated levels indicating under-replacement and suppressed levels over-replacement. In dogs with primary hypoadrenocorticism, PR...

DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly

Abstract The RNA exosome-associated helicase Mtr4/MTR4 (yeast/human) is recruited by adaptor proteins bearing Arch-Interacting Motifs (AIMs) to selectively degrade RNA substrates. Although the exosome targets diverse RNAs, only a few adaptors have been identified. Here, we extend...

The rise of carnivoran mammals in Europe through the lens of body mass

Carnivoran mammals (cats, dogs, bears, seals, etc.) and their kin radiated during the Palaeogene, among other carnivorous clades (hyaenodonts, mesonychians, and oxyaenodonts). This radiation has often been framed as a competition ultimately won by carnivorans, but the data suppor...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Conversational AI should fill the white space in mental health care, not replace humans

Abstract Conversational AI (CAI) is being rapidly deployed in mental healthcare, with much of the focus on chatbots delivering therapy directly to patients. However, this focus overlooks broader opportunities to improve mental healthcare as a system. Rather than replacing clinici...

Towards evaluating the effects of visualization and task types on urban planning decisions

Abstract. This study compares visualization types, i.e., 3D, 2D, Oblique 3D, and Combined 2D+3D, coupled in a pairwise fashion for different tasks and scenarios, and investigates their influence on decision-making across selected urban planning tasks. Specifically, we study site...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Acute respiratory distress syndrome in scrub typhus: a systematic review and meta-analysis

PURPOSE: Acute respiratory distress syndrome (ARDS) is an important complication of scrub typhus and is associated with substantial mortality. The primary objective of this systematic review and meta-analysis was to estimate the proportion of hospitalised patients with microbiolo...

Industry partnerships

Overview of industry programs to support translational life science research in academia (& start-ups)

Diabetes Mellitus and Long-Distance Running: A Systematic Review

BACKGROUND: Athletes with diabetes increasingly participate in endurance running, benefiting from physiological adaptations and technological advances like continuous glucose monitoring (CGM) for glycemic control. So far, no comprehensive review summarizing the current knowledge...

Evaluation of Dual-Near-Infrared-Wavelength Photobiomodulation Therapy for the Treatment of Canine Otitis Externa: A Prospective Multicenter Pilot Study

This is the first prospective multicenter study investigating photobiomodulation (PBM) in canine OE. Inclusion criteria required an Otitis Index Score 3 (OTIS-3; scale 0–3) ≥1 for erythema and discharge and a Budach cytological score ≥1+ (scale 0–4+) for Malassezia spp. and/or ba...

A continuous-time approach to short-term activity-cognition dynamics.

= 44.67, 92% non-White). Replicating the older adult findings, moments dominated by passive activities showed beneficial within-person cross-effects on subsequent processing speed, alongside negatively correlated random fluctuations. In contrast, between-person associations indic...