University of Zurich

Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting

Background Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high‐sensitivity cardiac troponin (hs‐cTn). cMyC (cardiac myosin‐binding protein C), because of its fas...

From protogalaxy through thick and thin: Why did the Milky Way evolve in three kinematic phases?

Abstract APOGEE and Gaia data suggest the Milky Way’s kinematic structure evolved through three distinct phases: a disordered protogalaxy, which ‘spun up’ into a thick stellar disk, and then ‘cooled down’ to a final cold, thin stellar disk. We use a suite of FIRE-2 cosmological z...

Antenna subtraction at NNLO for heavy quark pair production at hadron colliders: the non-diagonal channels

A bstract We present the calculation involving the qq , qq ′ and qg partonic channels contributing to heavy-quark pair production at hadron colliders through next-to-next-to-leading order in QCD using the antenna subtraction formalism. The calculation is performed in full colour...

Reported practice patterns in the use of local antibiotics for fracture-related infection among SICOT respondents: an international survey

Abstract Background Local antibiotics are increasingly used in the management of fracture-related infection (FRI), but international practice patterns regarding their indications, antibiotic selection, and application methods remain heterogeneous and insufficiently standardised....

A Multinational Study of Orientation-Aware Deep Learning for Automated Detection of Retained Roots and Periodontal Bone Loss

Introduction and aims Accurate radiographic assessment of retained roots (RR) and periodontally compromised teeth (PCT) are critical for dental diagnosis. This study aimed to develop and evaluate deep learning models for the automated detection and classification of these patholo...

At what cost? Governing unity in Tibetan diaspora nationalism

This article examines Tibetan exile politics as a form of long-distance nationalism unfolding within a deterritorialized arena linking homelands, host states, and global solidarity networks. While diasporas are often portrayed as cohesive political actors, Tibetan exile politics...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

On Nonparanormal Likelihoods

Nonparanormal models describe the joint distribution of multivariate responses via latent Gaussian, and thus parametric, copulae while allowing flexible nonparametric marginals. Some aspects of such distributions, for example conditional independence, are formulated parametricall...

Creating an Ear and Hearing Health Culture for Professional Ear Users: Current Perspectives on Challenges, Management, and Recommendations

Professional ear users (PEUs), including musicians, instrument makers, or sound engineers, depend on highly trained auditory abilities for occupational performance. Given these demands, PEUs may benefit from tailored prevention, diagnostics, and treatment. Ear and hearing disorde...

Rod photoreceptors have a dual dependency on both aerobic glycolysis and OXPHOS and diverge metabolically from other retinal neurons

The retina metabolizes glucose into lactate, a hallmark of aerobic glycolysis known as the Warburg effect. Although evidence points to rod photoreceptors as the primary source of aerobic glycolysis, a comparison of the energy metabolism in different retinal neurons has yet to be...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Snake kolmiovirus encodes a single form of delta antigen and shows no evidence of translation from ORF2

Hepatitis D virus (HDV) is a satellite virus that utilizes hepatitis B virus (HBV) as a helper for infectious particle formation. HDV was originally identified as a novel antigen in liver biopsies of HBV patients, and later studies showed the ‘delta’ antigen (DAg) to be the sole...

Suppression of spectral gap and flat bands on a cuprate superconductor side-surface

Abstract Side surfaces of cuprate superconductors are expected to display a suppressed d -wave order parameter and zero-energy topological flat bands with a large density of states, making them susceptible to symmetry broken orders. Yet such surfaces have never been investigated...

From “Aha!” to “Haha!”: Humour processing and insight problem-solving in autism

Humour processing requires the integration of disparate information and shares cognitive mechanisms with insight problem-solving, in which previously unrecognized connections are suddenly discovered through an “Aha!” experience. Autistic individuals may differ from neurotypical i...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Autoinducer-2 functions as both a quorum-sensing and metabolic signal in Escherichia coli

ABSTRACT Bacteria integrate diverse environmental signals to coordinate behavior, yet the relationship between nutrient sensing and quorum sensing (QS) remains incompletely understood. Autoinducer-2 (AI-2) is unique among QS signals in that its production is tightly linked to cen...

To Greater Twist: A Kinetically Biased π‐Radical Cascade

π-Radical cascades of open-shell graphene fragments-exemplified by phenalenyl and related systems-are emerging as a versatile synthetic tool for constructing complex polycyclic aromatic frameworks. While previous investigations showed that the reaction outcome can be reduced to a...

Moral and perceptual conflict processing are implemented by distinct brain activation and functional connectivity patterns

While humans resemble other primates in terms of motor and perceptual abilities, our behavior is uniquely characterized by morality—the ability to choose our actions based on specific ethical values. The evolutionary origins and neurobiological basis of moral behavior are debated...

Neoliberal policies as catalysts of inequality after disasters: Mapping (Im)mobilities and the effects of floods in Porto Alegre, Brazil

The 2024 floods in Porto Alegre, Brazil, suggest how urban planning shaped by neoliberal reforms may intensify vulnerability during climate disasters. Using spatial analysis, policy review, and a survey of 417 residents across five neighborhoods, this study finds that the privati...

Combined lower- and upper-limb post-activation performance enhancement does not clearly improve 50 m front crawl performance in national-level swimmers

Abstract Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve sprint-swimming readiness, but the effects of combined lower- and upper-limb conditioning remain unclear. This study examined the acute effects of an individually timed combi...