University of Zurich

Singlet Oxygen-Responsive MRI Contrast Agents

Abstract In vivo imaging detection of singlet oxygen (1O2) produced by photodynamic therapy remains a challenge. To address this unmet necessity, two Gd3+-based multicyclic magnetic resonance imaging (MRI) probes 1 and 2 were synthesized and characterized for their ability to rea...

Characterization of chemoresistant cell populations improves risk stratification and therapy prediction in pediatric acute myeloid leukemia

Most pediatric acute myeloid leukemia (pAML) patients achieve complete remission after chemotherapy, yet nearly 40% ultimately relapse and die from their disease. High risk cases are typically referred for stem cell transplantation (SCT) in first remission, but because SCT is ass...

A TERRA-NONO axis drives fibroblast reprogramming in cancer

The molecular mechanisms linking chromosome homeostasis to fibroblast reprogramming into cancer-associated fibroblasts (CAFs) remain poorly understood. Here, we identify a clinically relevant, telomere-associated nuclear pathway driving CAF activation across multiple human cancer...

Surgical Site Infections After External Ventricular Drain Placement: Incidence, Patient-Related, and Periprocedural Risk Factors.

BACKGROUND AND OBJECTIVES: External ventricular drain (EVD) placement is a routine neurosurgical procedure for cerebrospinal fluid (CSF) diversion. Despite standardized procedures, a considerable risk of infection remains. While CSF EVD-related infections (EVD-RI) are common and...

Awe as a Transformative Emotion: An Integrative Review, Metamorphosis Model, and Research Agenda

Awe has attracted substantial scholarly attention but its implications for management remains fragmented across different accounts of what awe is and why it matters. In this review, we first show that the literature has developed around three dominant perspectives—collective self...

A neuromodulable current-mode silicon neuron for robust and adaptive neuromorphic systems

Abstract Neuromorphic engineering makes use of mixed-signal analog and digital circuits to directly emulate the computational principles of biological brains. Such electronic systems offer a high degree of adaptability, robustness, and energy efficiency across a wide range of tas...

BCA ADEMP-PreReg

Completed ADEMP-PreReg (Siepe et al. 2024) pre-registration plan for a simulation study included in the revision of the paper on Bayesian conjugate analysis by Degen, Pawel, and Held. Version 1: Pre-registration protocol only. Version 2: Added final simulation results. prereg-sim...

The Impact of Explanation Characteristics on the Effects of Recommender Systems Explanations

There seems to be a consensus that adding explanations to AI systems, such as recommender systems, can have positive effects, such as increasing a user’s trust, the transparency of the system, or the efficiency of a decision-making process. It is to this date unclear, though, how...

Industry partnerships

Overview of industry programs to support translational life science research in academia (& start-ups)

The Latest Epicycle? Queloz’s Conceptual Ethics

Abstract This critical notice assesses Matthieu Queloz’s The Ethics of Conceptualization , highlighting its compelling pragmatist account of concepts as tools shaped by human needs. It argues, however, that Queloz’s reasons for concept use do not constitute a fundamentally new ki...

Rare LRRFIP1 variants contribute to pathophysiology of severe early-onset scoliosis and common scoliotic phenotypes

Despite enormous advances in clinical genomics, idiopathic scoliosis remains an enigmatic condition with poorly understood genetic and pathophysiological underpinnings impeding molecular diagnosis and the development of targeted treatments. We performed linkage analysis, exome, g...

The stripe state at 1/8 Ba doping hosts optimal superconductivity in La-214 cuprates under low in-plane stress

Abstract The cuprate system La 2− x Ba x CuO 4 (LBCO) exhibits a pronounced sensitivity to in-plane uniaxial stress, particularly near the 1/8 doping anomaly, where stripe order strongly suppresses bulk superconductivity. While previous studies have focused on compositions close...

Collectively (re)mapping creator (dis)enchantment

Knowledge is best negotiated and produced through collective dialogue. Reading the thoughtful responses to our work, the importance of diverse perspectives emerged as an opportunity to reflect and build. Philosopher Ludwik Fleck defined a thought collective as “a community of per...

Persisting perceptual abnormalities in psychedelic users are associated with conditioned hallucinations and impaired sensory processing

Abstract Serotonergic psychedelics (SP) are increasingly used in clinical research and naturalistic settings, but their psychotic-like side effects, including persisting perceptual abnormalities (PPAs), are poorly understood. Psychosis-associated hallucinations are associated wit...

Electroretinographic assessment of retinal function in preterm infants using the RETeval™ device: a proposal for reference data

Abstract Purpose To establish age-adjusted flicker ERG reference values in premature infants through serial recordings, aiming to characterize retinal functional maturation and support diagnostic interpretation in retinopathy of prematurity screening. Methods This prospective lon...

Surface Observables, 2-Knot Invariants, and Nonabelian Electric Fluxes

Abstract This work introduces a surface observable for nonabelian four-dimensional BF theory with a cosmological term. The surface observable yields new 2-knot invariants that may extend beyond known examples such as the Alexander invariant. By BV pushforward, the surface observa...

SpaCEy links spatial tissue patterns to clinical outcomes using explainable graph neural networks

Abstract Tissues are complex ecosystems organised in space, and alterations in this organisation underpin multiple diseases. Spatial omics enables molecular profiling of tissue organisation, but linking these patterns to clinical outcomes remains challenging. We present SpaCEy (...

Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial

Fluid resuscitation in early septic shock has a narrow therapeutic index. Signals of fluid intolerance are frequently present during early resuscitation, yet current resuscitation strategies do not incorporate them to guide when to limit fluid administration. We evaluated whether...

Stimulatrix: An open-source automated platform for high-throughput functional characterization of engineered contractile tissues

Engineered cardiac and skeletal muscle tissues suspended between flexible posts support disease modeling and pharmacology, yet their stimulation, longitudinal imaging and quantitative analysis often remain fragmented and labor-intensive. Here we present Stimulatrix, an open-sourc...

Complete Reporting for Transparent Reproducibility Efforts (CORTRE)

The CORTRE project develops a consensus-based reporting guideline for reproduciblity efforts -- projects that systematically re-examine previously published findings to investigate an aspect of their reproducibility. The project was launched at the Responsible Research in Action...