University of Zurich

Complete Reporting for Transparent Reproducibility Efforts (CORTRE)

The CORTRE project develops a consensus-based reporting guideline for reproduciblity efforts -- projects that systematically re-examine previously published findings to investigate an aspect of their reproducibility. The project was launched at the Responsible Research in Action...

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

Abstract Background Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. Methods We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lip...

Incidental findings from panoramic radiographs: A systematic review with meta-analysis

Abstract Purpose The use of radiographs is widely spread, both among general dentists and specialists, since it provides a view of the oral and perioral tissues using a relatively easy-to-acquire and low-dose image. The aim of this systematic review was to critically appraise and...

How 8 years of social and individual learning interact to shape ecological competence in orangutans

Cultural learning permeates human skill and knowledge acquisition. To understand its importance for nonhuman apes, we analyzed just under 7000 records of behavioral bouts of social and individual learning across wild orangutans’ 8-year dependency period to assess their combined e...

Load-bearing capacity and Weibull characteristics of inlay-retained fixed dental prosthesis: Effect of zirconia type, bonded substrate and aging

Abstract Objectives This study evaluated the load-bearing capacity and reliability of different zirconia materials used for inlay-retained fixed dental prostheses (IRFDPs) , considering the influence of substrate type (tooth substrate or resin composite) and thermo-mechanical agi...

Stream biodiversity and function benefit from forest fragments in agricultural landscapes

Abstract Riparian forests buffer stream ecosystems from intensive land use. However, with ongoing land-use changes, riparian forests often remain as isolated fragments. Despite this, the relevance of isolated forest fragments in deforested landscapes remains unclear. We evaluated...

Albendazole Treatment of Alveolar Echinococcosis in a Trial Based on a Cross Sectional Ultrasound Study in Kyrgyzstan

ABSTRACT Background Human alveolar echinococcosis (AE) is a potentially fatal parasitic disease. In the low‐resource country of Kyrgyzstan, it is essential to develop protocols to manage the large number of AE cases being diagnosed. Methods A randomised trial was undertaken to ex...

How I do it: microsurgical extraforaminal sequestrectomy through a midline intertransverse approach

Abstract Background Several surgical approaches exist for extraforaminal (far lateral) lumbar disc herniations, including paraspinal Wiltse-type, interlaminar, lateral intertransverse, and combined medial–lateral techniques. Method We present microsurgical extraforaminal sequestr...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Conditional gender gaps in welfare state support: The role of labor market and household inequality

Abstract Why are women more supportive of the welfare state than men? Existing literature on this attitudinal gender gap focuses mainly on how men and women, on average, experience varied risks in the labor market. Feminist scholarship argues that the welfare state has the potent...

N,N-Dimethyltryptamine and harmine formulation alters transient EEG topography sequences near the peak of the psychedelic state

BACKGROUND: Psychoactive serotonin 5-HT2A receptor agonists are potent modulators of awareness. Influential theories propose that psychedelics alter whole-brain dynamics by increasing neural signal diversity and dynamic flexibility. Beyond temporal variability, it is an open ques...

Underreporting in count data models: some new results and an application to labor mobility

Abstract Winkelmann and Zimmermann (1993), although available only as a working paper, has initiated a small but persistent literature on underreporting in count data models. Their Poisson-logistic (Pogit) model was initially developed to estimate the determinants of the number o...

PRISM with a Pinch of Salt: Simple, Efficient, and Strongly Unforgeable Signatures from Isogenies

Abstract The problem of computing an isogeny of large prime degree from a supersingular elliptic curve of unknown endomorphism ring is assumed to be hard both for classical as well as quantum computers. In this work, we first build a two-round identification protocol whose securi...

An interpretable deep learning framework for classifying neuronal morphologies using topology and graph neural networks

Abstract Neuronal shape determines how neurons process and integrate information, yet a consistent and objective classification of neuronal morphologies remains elusive. Current approaches rely heavily on subjective expert views or on predefined features, limiting reproducibility...

The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer

Breast cancer progression to visceral organs such as the lung and liver is associated with poor prognosis. Yet, these organs have diverse cellular microenvironments that may differentially influence cancer cell behavior. Here, we show that breast cancer metastases differ in their...

Comparative cost analysis of community-based tuberculosis screening: Computer-Aided Detection (CAD) alone versus CAD with point-of-care C-reactive protein testing in South Africa and Lesotho

Community-based active case finding (ACF) for tuberculosis (TB) is recommended in high-burden settings, yet evidence on implementation costs from prospective programmatic data remains limited. We estimated and compared the costs of two community-based ACF screening approaches: Co...

The far-right’s tug-of-war with multilateral democracy promotion

Far-right parties are perceived as central actors in the contestation of international organisations: as nativist anti-pluralists, they reject constraints on popular sovereignty, especially those emanating internationally. Multilateral democracy promotion stands emblematically fo...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Oncogene-driven genomic profiles are linked to poor overall survival in muscle-invasive bladder cancer (MIBC)

Abstract Purpose Muscle-invasive bladder cancer (MIBC) is a genomically complex disease with limited biomarkers for predicting patient outcomes. This study aimed to identify molecular correlates of overall survival in MIBC through comprehensive genomic profiling. Methods Tumor DN...

High-salt diet modulates endocrine regulation between cortisol and FGF23

Excessive dietary salt intake is a global health concern, affecting cardiovascular, renal, and bone health. While the renin-angiotensin-aldosterone system (RAAS) is a known regulator of dietary salt-induced hormonal responses, the impact of adrenal cortisol remains unclear. Here,...