University of Washington

Multi-sensor continuous-flow bioreactor for dynamic and scalable cell culture

Abstract Bioreactors are essential tools in tissue engineering and advanced cell culture because they provide dynamic environments that support cellular growth, organization and tissue maturation. However, most existing systems lack integrated real-time monitoring and feedback co...

Rural Background, Training Exposure, and Rural Practice Location Among US Physicians

This cross-sectional study assesses the interdependence of rural background and training as factors associated with rural practice among US physicians.

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...

The Zooplankton International Geospatial dataset: A global repository of spatiotemporal freshwater zooplankton community composition data from lakes and reservoirs to support ecological research

Abstract Zooplankton transfer substantial energy in aquatic food webs and are used as indicators of environmental change. Syntheses of zooplankton community dynamics globally require datasets that span a wide range of environmental gradients; however, these datasets are limited d...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD), an autosomal domina...

Second HarmonicNonlinear Warburg Admittance AnalysisEliminates Information Loss from Linearization in Traditional EIS:Theory and Experimental Validation

Abstract Low-frequency impedance or admittance experiments of reversible redox couples in well-supported quiescent electrolyte are normally analyzed using a linearized semi-infinite Warburg element with a single lumped parameter. Because each species of a redox couple has a disti...

The Digital Mental Health Study assessed feasibility of large-scale digital sensing for depression and anxiety

Abstract Data passively obtained from smartphones and wearables can provide nearly continuous objective information that enables quantification of states and traits across broad physiological, behavioral, and emotional domains impacted in mental health conditions, including depre...

Survey Authentication Challenges During a Geriatrics Knowledge Assessment Pilot

ABSTRACT Background In this methodological Brief Report, we describe a multi‐institutional survey authentication challenge encountered during pilot deployment of the Age‐Friendly Knowledge Assessment Tool (AF‐KAT), a geriatrics knowledge assessment for graduating medical students...

Engaging Black and Latinx Communities in Building Capacity for Behavioral Health

Introduction: COVID-19 affected nearly every aspect of people’s lives worldwide. In the United States, the consequences of closures and quarantine increased stress, worry, isolation, and mental health and substance use problems, leading to behavioral health (BH) problems. These c...

A comprehensive assessment of tandem repeat genotyping methods for Nanopore long-read genomes

Tandem repeats play critical roles in human disease and phenotypic diversity but are among the most challenging classes of genomic variation to measure accurately. Long-read sequencing has the potential to accurately characterize long and complex tandem repeats. While an increasi...

Tijuana river pollution crisis: health symptoms and environmental perceptions from the Healthy Water Healthy Air Study

Untreated sewage, industrial waste, and urban runoff carried by the Tijuana River from Mexico into the U.S. has created a longstanding transboundary environmental crisis. This pollution significantly intensified in July 2024, with border community members reporting noxious odors...

The Impact of Septorhinoplasty on Work Productivity and Activity Impairment: A Multi‐Institutional, Prospective Cohort

OBJECTIVE: To evaluate the effect of septorhinoplasty on work productivity and activity impairment. STUDY DESIGN: Prospective cohort. SETTING: Four tertiary institutions. METHODS: Adults undergoing septorhinoplasty were administered surveys preoperatively and 3 to 8 months postop...

A foundation model for sleep-based risk stratification and clinical outcomes

Abstract Clinical sleep studies capture multiple physiologic signals, yet interpretation is often reduced to single summary measures of limited prognostic value, such as the apnea–hypopnea index. We present a foundation model that learns rich representations of sleep physiology f...

Variables Associated with Prescription Opioid Misuse in Individuals with Chronic Noncancer Pain

OBJECTIVES: Current research highlights the importance of assessing the risk of opioid misuse in people with chronic noncancer pain (CNCP) before initiating treatment with these medications. Existing instruments to assess this risk demonstrate limited predictive capacity and lack...

Exploring Middle and High School Personnel’s Definition and Knowledge of Evidence-Based Practices for Autistic Students

Background Mandates that educators use evidence-based practices (EBP) with autistic students have not led to their widespread or consistent implementation, despite their growing availability. EBP knowledge is integral to effective implementation, and prior studies have shown that...

Effect of mentorship on perceived stress, perceived social support at work, and job satisfaction among tradeswomen in the United States: a randomized controlled trial

Objective: Tradeswomen face psychosocial hazards, including harassment and discrimination, associated with adverse health. Mentorship has been recommended but not evaluated as a potential solution. Methods: In this randomized controlled trial, women apprentices across the US and...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...

Performative Music Education Pathways: Bomba as a Framework for Music Teaching and Learning

For decades, music education has sought models that move beyond the confines of formal instruction. Performative Music Education (PME) offers a framework for meaningful learning experiences, grounded in philosophical perspectives from diverse fields. PME fosters musical skills, k...

Low‐Temperature Imidization of Polyimides (PI) for Scalable Manufacturing of Flexible Wearable Electronics

Polyimide (PI) is widely used in flexible electronics because of its excellent mechanical and thermal stability; however, its high imidization temperature (>200 °C) is incompatible with low‐cost polymer substrates such as polyethylene terephthalate (PET), limiting scalable rol...