University of Washington

Multi country training to strengthen leadership among administrative staff of research ethics committees and national regulatory bodies in the East African Community

Clinical research in the East African Community (EAC) has expanded significantly in response to epidemics, increasing the complexity and workload. Research ethics committee (REC) and National research regulatory (NRA) members involved in leadership and administrative work play a...

An Explicit Energy-Conserving Particle Method for the Vlasov–Fokker–Planck Equation

Abstract. We propose an explicit particle method for the Vlasov–Fokker–Planck equation that conserves energy at the fully discrete level. The method features two key components: a deterministic and conservative particle discretization for the nonlinear Fokker–Planck operator (als...

“Clean” Meat? Regulatory Entrepreneurship and Jurisdictional Contestation in a Nascent Industry

In nascent industries, uncertainty about which regulatory agency has jurisdiction is often a major challenge for pioneering ventures. Yet, much of the literature on new ventures’ nonmarket strategy takes for granted the existence of a designated regulator. How do ventures manage...

How Accurately Can We Describe Spin Crossover?

Abstract The complicated physicochemical properties of metal complexes that exhibit thermal spin crossover make it difficult for routine electronic structure calculations to yield an accurate transition temperature prediction, T1/2. The difficulty lies in the intricate connection...

Exploring the Potential of Parent Report for Autism/Developmental Screening at the 18-Month Visit

PURPOSE: To develop optimal algorithms of parent-administered items to improve the detection of autism and other developmental disorders at the 18-month visit. METHODS: at scheduled 18-month pediatric visits via an online system. Ninety-six children with positive screens and 314...

Three decades of urban densification reduced winter direct sunlight access across China’s old urban cores

Urban densification is widely promoted to improve land-use efficiency and curb sprawl, but it can reduce winter sunlight in old urban cores, an important dimension of urban livability. Although three-dimensional (3D) urban form is known to shape sunlight availability, most studie...

Sliding Disassembly of van der Waals Heterostructures

Abstract Many recent advances in our understanding of two-dimensional electron systems stem from van der Waals (vdW) heterostructures. The assembly process relies on the weak bonding across interfaces between layered vdW compounds, making it possible to construct exceptionally cl...

When, Where, and How Much: Toward Smarter Design and Delivery of CAR T-Cell Therapy

Abstract Chimeric antigen receptor (CAR) T-cell therapies have fundamentally reshaped clinical oncology by achieving durable remissions in refractory hematologic malignancies. However, their broader translation remains bottlenecked by severe, treatment-associated hyperinflammator...

Decoupling the Role of Nanoparticle Rigidity and Chemistry in Particle Transport through the Brain Parenchyma

Abstract Drug delivery to the brain involves challenging transportation across multiple biological barriers. Despite the great tunability of polymeric nanoparticles, the synthetic challenge of varying the physical property of a nanoparticle without varying its chemical formulatio...

Best Practices in Nanocrystal Synthesis and Characterization

Conspectus Colloidal nanocrystals exhibit quantum-mechanical phenomena inaccessible in bulk matter, and their properties can be tuned via chemically manipulating their composition, size, shape, and surface chemistry. Decades of development have produced a remarkable synthetic lib...

Mixtures of Neural Network Experts With Application to Phytoplankton Flow Cytometry Data

ABSTRACT Flow cytometry is a valuable technique that measures the optical properties of particles at a single‐cell resolution. When deployed in the ocean, flow cytometry allows oceanographers to study different types of photosynthetic microbes called phytoplankton. It is of great...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Attitudes toward and knowledge of the potential medicinal properties of cannabis among incoming medical students: a cross-sectional survey

Abstract Background Although medical cannabis (MC) is legal in most US states, < 10% of medical schools’ curricula include MC content, and prior research suggests medical students hold variable knowledge and attitudes. This study assessed incoming medical students' knowledge of M...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Emergent properties of urban landscapes shape urban eco-evolutionary dynamics

Abstract Context Urbanization transforms natural ecosystems into heterogeneous and fragmented landscapes, creating novel selective pressures that can drive eco-evolutionary dynamics. However, the specific role of urban spatial structure in shaping these dynamics remains poorly un...

Small area estimation in low- and middle-income countries with the sae4health R shiny application

Abstract Accurate subnational estimation of health indicators is critical for public health planning, particularly in low- and middle-income countries, where data and analytic tools are often limited. sae4health is an open-access Shiny application ( https://rsc.stat.washington.ed...

Potentially Lethal Concentrations of 6PPD-Quinone Occur in Endangered Species Act Listed Aquatic Habitats of Central California

Abstract Roadway runoff is the major source of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), a tire rubber-derived transformation product that causes acute mortality in some salmonid species. Despite its widespread occurrence, little data exist for watershed...

Comparative Efficacy of Embolic Agents for Single-Session Meningeal Artery Embolization and Surgical Evacuation: Evaluating Liquids, Particles, and Adjunct Coils

BACKGROUND AND OBJECTIVES: Single-session middle meningeal artery embolization (MMAE) combined with surgical evacuation is an emerging strategy for management of patients with chronic subdural hematoma (cSDH). However, comparative outcome data based on embolic material selection...

Tumor microbial biodiversity and microsatellite instability in colorectal cancer

Background Growing evidence links the gut microbiome to colorectal cancer (CRC) progression, with certain bacterial species enriched in specific molecular tumor subtypes. DNA mismatch repair deficiency in CRC, evidenced by the presence of microsatellite instability (MSI), has bee...

Evolution of Endoscopic Spine Surgery: Contemporary Advances and Future Directions

Abstract Purpose of review Endoscopic spine surgery has evolved from non-visualized percutaneous discectomy only, into a comprehensive minimally invasive surgical platform with expanding indications across cervical, thoracic, and lumbar pathology. This review examines endoscopic...