University of Washington

Resonance-enhanced integrated acousto-optic beam steering

Optical beam steering is a key technology for free-space optical communication, sensing, and imaging. Mechanical beam steering systems suffer from limited scanning speed and bulky form factors, while existing solid-state solutions rely on pixelated synthetic aperture that require...

Bio‐Inspired Bidirectional Proton Regulatory Mechanisms by Anhydride‐Based Hydrogel Electrolytes for High‐Performance Aqueous Zinc‐Ion Batteries

ABSTRACT Aqueous zinc‐ion batteries (AZIBs) employing hydrogel electrolytes offer significant advantages in mitigating short‐circuit and electrolyte leakage risks. Nevertheless, the sluggish transport kinetics of Zn 2 + and severe interfacial instability of zinc anodes still seve...

BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer

Abstract Castration-resistant prostate cancer (CRPC) progression despite treatment with potent androgen receptor (AR) antagonists such as enzalutamide is a major clinical challenge. The mitotic kinase BUB1B is a central member of an oncogenic seven-gene network that drives CRPC....

Wafer-scale conformal metasurface optics

Curved and conformal optics provide additional geometric degrees of freedom that enable enhanced optical performance while satisfying non-optical constraints such as ergonomics, aerodynamics, and wearability. However, existing fabrication approaches for curved metasurfaces are li...

Trends in Medicare Work Relative Value Unit Payment Rates Across Physician Specialties: 2018-2024

BACKGROUND: Recent Medicare Physician Fee Schedule revisions have sought to narrow perceived compensation differences between medical and surgical specialties, but their effects on work relative value unit (wRVU) payment rates are unknown. We estimated contemporary specialty-leve...

De Novo Design and Structural Optimization of Mn(salen)‐Based Artificial Metalloenzymes for Asymmetric Sulfoxidation

ABSTRACT Artificial metalloenzymes (ArMs) exhibit exceptional selectivity, yet extending their reactivity beyond native cofactors remains a major challenge. While previous designs using native protein scaffolds to incorporate nonnative cofactors have been reported, de novo protei...

Trends in missing responses to suicide-related indicators among U.S. adolescents by race/ethnicity and sex, 2001-2021

OBJECTIVES: Missingness to suicide-related survey items may bias adolescent suicide surveillance and limit subgroup comparisons. Prevalence and trends of missingness to suicide-related indicators were examined among U.S. adolescents from 2001 to 2021. STUDY DESIGN: Trend analysis...

Employment-Related Risks in a Clinical Trial of Psychedelic Treatment for Chronic Pain

Chronic pain is a significant health problem affecting up to 20% of Americans (Yong et al. 2022), negatively affecting overall health and quality of life, causing disability, and burdening healthca...

Mitotic molecular braking prevents DNA damage in anaphase

During mitosis, duplicated sister chromatids are sorted into opposite poles of a dividing mother cell. In all eukaryotic cells, the speed at which sister chromatids are separated during anaphase, the final phase of mitosis, is limited by targeted regulatory mechanisms. However, t...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...

Health Care for Immigrant Children: Discussing Birth Country During Pediatric Appointments

Information about a child's country of birth (also called nativity) is highly relevant to pediatric care, as it informs the recommendations pediatricians will make regarding screening for serious conditions such as elevated blood lead levels, viral hepatitis, and tuberculosis. Ho...

Co-design of a digital health intervention to provide pharmacy-based, person-centered contraceptive decision support for youth in Kenya

Adolescent girls and young women (AGYW; age 15–24 years) face intersectional barriers to undesired pregnancy prevention, with profound health consequences. Community pharmacies remain a relatively untapped opportunity to improve the reach and quality of contraceptive care for you...

A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket

Frailty is increasingly recognized as a clinically relevant measure of biological aging, yet comparable assessment tools are lacking for scalable invertebrate models. Here, we introduce a Composite Frailty Index (CFI) for the house cricket ( Acheta domesticus ) integrating automa...

Targeting tryptophan hydroxylase 1 restricts growth and suppresses plasticity in neuroendocrine prostate cancer

Advanced prostate cancer has increasingly developed a lethal neuroendocrine form, small cell/neuroendocrine prostate cancer (NEPC), as a consequence of the widespread use of highly potent androgen receptor signaling inhibitors in castration-resistant disease. The molecular mechan...

Atmospheric Fate of Acyloxyl Radicals: Decomposition versus Isomerization

Abstract Acyloxyl radicals (RCO2) are a common type of alkoxyl radical formed in the gas-phase oxidation of organic compounds in the atmosphere. Previous theoretical studies have predicted that the decomposition of RCO2 to an alkyl radical R and CO2 is a very fast reaction, sugge...

Immunomodulation of the Innate Host Response by Mesenchymal-Derived Versican during Influenza A Virus Infection

Viral and bacterial lung infections place a significant burden on public health. Versican, an extracellular matrix (ECM) chondroitin sulfate proteoglycan, coordinates the innate immune response in multiple experimental models. Versican’s potential as an immunomodulatory molecule...

Prioritizing Global Health Education in Pulmonary and Critical Care Fellowships: An Applicant Survey

Abstract Background Global Health (GH) is expanding, offering an increasing number of opportunities for engagement to trainees in medical schools and residency programs. This expansion of opportunities has not yet reached those at the fellowship level, particularly in Critical Ca...

Perspectives on adverse events reporting in hybrid implementation science (IS) clinical trials of approved medications in Sub-Saharan Africa

Implementation science (IS) hybrid type 2 and 3 clinical trials and pure implementation research of approved medications test strategies to increase uptake of evidence-based interventions (EBIs) with well-established safety profiles. Guidance on adverse event (AE) monitoring and...

Robust valley-polarized excitonic Mott states and doublons enabled by stacking-controlled moiré geometry

Atomically-thin moiré superlattices offer a platform for interacting bosons, where strong onsite repulsion $${U}_{{{\rm{xx}}}}$$ suppresses double occupancy and supports excitonic Mott states at unit filling. However, moiré confinement also enhances phonon- and disorder-assisted...

GRAIN: Mapping the World's Irrigation Canals and Why It Matters for Water, Food, and Climate

Abstract The engineered channels that carry water from large dams and rivers to agricultural fields, known as irrigation canals, are the link between source (lakes and reservoirs) and sink (farmlands). These canals make cultivation of crops possible across millions of hectares of...