University of Washington

Hyperglycemia Drives an Activated, Lipid-Laden Nonclassical Monocyte Phenotype in Diabetes

The presence of lipid-loaded macrophages in the artery wall and kidney characterizes diabetic atherosclerotic cardiovascular disease and diabetic kidney disease, respectively. Monocytes, the bone marrow–derived precursors of macrophages, accumulate lipids in response to hyperchol...

Hearing Screening Among Underserved US Adults: A Scoping Review of Modalities and Determinants

ABSTRACT Objective To evaluate existing literature on hearing screening outcomes and follow‐through among the adult population in the US. Data Sources PubMed, Ovid Medline, Scopus, and CINAHL databases. Review Methods A comprehensive literature search was conducted across PubMed,...

Impact of Biologic Therapy on Emergency Department Utilization in Pediatric Hidradenitis Suppurativa Patients

Hidradenitis suppurativa (HS) is a chronic inflammatory condition that often begins in adolescence and is associated with substantial morbidity and increased healthcare utilization, including emergency department (ED) visits. Using the TriNetX Global Network, a retrospective coho...

Epigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs

The extraordinary lifespan variation in domestic dogs provides a natural experiment for testing how intrinsic rates of biological aging shape lifespan. Using 1640 methylomes from 894 dogs, we developed an epigenetic clock that predicted mortality and demonstrated that epigenetic...

Increases in Regional Brain Volume and Thickness Following ECT and Relationships With Changes in Depressive Symptoms and Peripheral Inflammation

OBJECTIVES: Treatment-resistant depression (TRD) is highly prevalent and debilitating. Electroconvulsive therapy (ECT) is an efficacious intervention for TRD. This study sought to clarify ECT's mechanisms by examining relationships between ECT-induced changes in regional brain vo...

Comprehensive Experimental and Computational Spectroscopic Study of Electronic Coupling in Solvated Mixed Valence Multimetal Complexes Using Photons from the IR through X-rays

Abstract We present a comprehensive experimental and computational spectroscopic study of the trinuclear cyanide-bridged mixed-valence complex trans-[RuIIL4{(μ-NC)FeIII(CN)5}2]4– (FeRuFe), where L = pyridine or 4-methoxypyridine dissolved in methanol and water. Four complementary...

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse over nearly two weeks of development. From one embryo, we reconstruct a time-calibr...

Prehistoric global migration of vanishing gut microbes with humans

The gut microbiome is crucial for health and is affected strongly by lifestyle1. Many microorganisms commonly found in non-industrialized populations are disappearing or have become extinct in industrialized populations2–6. Studying which microorganisms have been long-term reside...

Use of split intein and myotropic AAV vectors enables effective preclinical gene therapy for dysferlinopathy

Limb-girdle muscular dystrophy type R2 (LGMDR2) is a genetic disorder characterized by progressive skeletal muscle weakness and degeneration. It is caused by mutations in the DYSF gene, which prevent dysferlin expression. Dysferlin protein is essential for muscle cell membrane re...

Hall Thruster Plume Characterization with Spatially Resolved Ion Energy Distribution Measurements

Standard methods for characterizing thruster efficiency using plume diagnostics are insufficient for electric propulsion systems with unknown or highly divergent plume structures. The standard practice of measuring a centerline ion energy distribution function is compared to spat...

Sharpening bordering: What counts, where it operates, and what endures

We respond to Laine's account of supply chains as bordering infrastructures by asking three linked questions: What counts as bordering, where does it operate, and what forms endure? We argue that bordering: (1) depends on identifiable mechanisms that differentially organize mobil...

Intra-individual variability of urinary non-persistent chemical concentrations during pregnancy in the ECHO Cohort

Studies of prenatal exposure to non-persistent chemicals often assume biomarker measurements from a single urine sample can represent exposure pregnancy. The validity of this assumption depends on biomarker concentration variability across gestation, which is not well-characteriz...

Design and development of AbortionCareTXT, a text message programme for individuals undergoing medication abortion

Abstract Background In Canada, medication abortion accounts for approximately 30% of the 100 000 annual abortions. Despite the advantages of privacy and autonomy, many individuals report feeling unprepared and uninformed about the medication abortion process. Mobile health (mHeal...

Ambient particulate matter exposure and children's blood pressure in rural California, 2019-2022

Elevated blood pressure (BP) in children is a risk factor for adult hypertension and is increasing globally. Ambient particulate matter (PM) is associated with increased BP in children in urban areas, but data from rural regions are sparse. The Children's AIRE study enrolled chil...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Improved Crystallization-Front Dynamics Reduce Buried-Interface Defects in Perovskite Solar Cells

Abstract Inverted perovskite solar cells have achieved substantial efficiency gains owing to advances in surface passivation; as a result, progress is now limited by buried defects at the perovskite/hole transport layer (HTL) interface. During top-down perovskite crystallization,...

Retrofitting language models to operate over bytes

Abstract Recent advances in artificial intelligence (AI) have largely been driven by large language models, deep neural networks that operate over discrete units called tokens. To represent text, most large language models use words or word fragments as the tokens, known as subwo...

Awareness and Use of Delta-8-THC Cannabis Products in the United States: Findings from National Surveys in 2021 and 2022

Introduction: While recreational marijuana remains illegal under federal law in the United States, “hemp-derived” products that contain less than ≤ 0.3% Delta-9-tetrahydrocannabinol (THC) were legalized in 2018. New classes of intoxicating products have proliferated, such as Delt...

Impact of Primary Prophylactic Colony-Stimulating Factor Delivery Method on Febrile Neutropenia: Secondary Analysis of a Pragmatic Cluster Randomized Clinical Trial

Purpose Primary prophylactic colony-stimulating factor (PP-CSF) is recommended for patients receiving chemotherapy with high risk of febrile neutropenia (FN). The impact of PP-CSF delivery method on FN is unknown. We performed a secondary analysis of SWOG S1415CD (Trial Assessing...

Alzheimer’s disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of...