University of Washington

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

Vibrational Spectraof Anionic Polycyclic AromaticHydrocarbons in the CH Stretching Region: Anthracene, Pyrene, Perylene,and Fluoranthene

Abstract The CH stretching region of the infrared spectra of polycyclic aromatic hydrocarbon radical anions (2700–3100 cm–1) is characterized by complicated band patterns that defy straightforward assignments from harmonic calculations. We compare experimental infrared photodisso...

Filtering spinal cord stimulation artifacts while preserving muscle activity during exoskeleton assisted walking after spinal cord injury

Analyzing surface electromyography in the presence of transcutaneous spinal cord stimulation requires the filtering of electrical stimulation artifacts. Limitations of previous filtering approaches include the use of a uniform filter and excessive removal of muscle activity of in...

Buffon discrepancy and the Steinhaus longimeter

Abstract Let be a convex set. We study the problem of distributing a one‐dimensional set with total length so that for any line in the number of intersections is proportional to the length as much as possible; we use the term Buffon discrepancy for the largest error. A constructi...

The blood system in Ukraine: Experience in martial law conditions

BACKGROUND/CASE STUDIES: Efficient blood and blood components supply is key to the stable operation of a health care system, especially to a civilian population and military under martial law. The blood system is an important component of a state's defense capability and national...

Revisiting the Fragmentation of Ketoconazole by Positive Electrospray Ionization Tandem Mass Spectrometry and Density Functional Theory Calculations

ABSTRACT Rationale Ketoconazole (KCZ) is a clinically essential antifungal and potent CYP3A4 inhibitor. Its gas‐phase fragmentation under positive electrospray ionization tandem mass spectrometry (ESI‐MS/MS) remains poorly characterized, undermining metabolite profiling and struc...

Shared and distinct gain-of-function consequences from pathologic cytoplasmic versus nuclear TDP-43

Abstract While predominantly nuclear localized in healthy cells, TDP-43 can transit between the nucleus and cytoplasm. In frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), TDP-43 accumulates in hyperphosphorylated cytoplasmic aggregates. Howeve...

Biomimetic Mustard Seed-Inspired Brush-Free Alternative for Effective Endoscope Channel Cleaning and Decontamination

Inadequate cleaning of flexible endoscope channels remains a major cause of healthcare-associated infections despite established reprocessing protocols. We developed biomimetic carbon balls inspired by mustard seed surface features as a brush-free adjunct for endoscope channel cl...

Pseudomonas aeruginosa-derived volatile organic compounds modulate AhR signaling to dysregulate airway mucus homeostasis

Pseudomonas aeruginosa frequently infects chronically diseased lungs and exacerbates airway mucus hypersecretion and failure in clearance. P. aeruginosa is metabolically versatile and secretes multiple volatile organic compounds (VOCs), which have been scrutinized as potential bi...

Firearm carrying practices and motivations: A mixed methods study among adults and youth

Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...

Comprehensive Analysis of US Health Care Spending on Injuries

BACKGROUND: Traumatic injury affects every age group, payer, and care setting in the United States, yet how injury-related spending distributes across these dimensions has not been comprehensively quantified. OBJECTIVE: To estimate US health care spending on injuries in 2022 by m...

Association between urbanicity–cooking fuel type and self-reported respiratory symptoms as a proxy for acute respiratory infection symptoms among children under two years across ten East African countries

Abstract Introduction Evidence remains limited on how urbanicity modifies the relationship between household cooking fuel type and respiratory symptoms in young children in low- and middle-income countries (LMICs). This study examined the prevalence of cough and dyspnea across te...

Exploring the protective role of school peers in substance use prevention among American Indian adolescents

Social network scholars have long recognized the role that social connections play in the substance use behavior of adolescents as they rely less on their parents/caregivers and more on their school peers. In this article, we explore the role of social networks as they relate to...

Weft-Backed Cooling Fabric for Personal Thermal and Moisture Management

Abstract During intense physical activity or exposure to solar radiation in hot and humid environments, heat continuously accumulates at the body surface and induces excessive sweating, thereby increasing the risks of dehydration, heat exhaustion, and even heat stroke, which seve...

Wastewater-BasedEpidemiology of Sexually TransmittedPathogens Across Scales

Abstract Wastewater-based epidemiology for sexually transmitted pathogens Chlamydia trachomatis (chlamydia), Neisseria gonorrhoeae (gonorrhea), and Treponema pallidum (syphilis) is sparse compared to viral targets despite their public health significance. We used multiplex, digit...

Investigating Associations Between Signal Intensity of Silent MR Angiography and Hemodynamic Information From 4D Flow MRI in Brain Arteriovenous Malformation

BACKGROUND: Whether signal intensity (SI) on Silent MRA reflects hemodynamics in brain arteriovenous malformations (BAVMs) is unclear. OBJECTIVES: To evaluate the relationship between Silent MRA SI and 4D flow-derived hemodynamic parameters and examine whether Silent MRA-based me...

Arterial Spin‐Labeling MRI at the Cortical‐ CSF Interface: A Novel Biomarker in Alzheimer Disease

BACKGROUND/OBJECTIVE: Arterial spin-labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF-adjacent water transport physiology. We developed an automated pipeline to extract cortical-CSF interface (IF) perfusion for compar...

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Structural variants (SV), genomic alterations spanning more than 50 base pairs, can significantly impact gene expression and protein function. However, their contribution to Alzheimer’s disease (AD) remains poorly understood. Leveraging a novel SV calling pipeline, we identified...

Optimization Strategies for the Design and Application of Titanium Structures in Aerospace Produced by Electron Beam Powder Bed Fusion

Material optimization of structures is critical in aerospace applications where the overall performance and lifecycle cost is highly sensitive to the vehicle weight. The added complexity enabled by powder bed fusion additive manufacturing technologies provides engineers the abili...

Evaluating harvest risk with limited data: A case study on polar bears ( Ursus maritimus ) in East Greenland

Abstract Evaluating the impact of human‐caused removals on wildlife is challenging, especially when population data are limited, future monitoring is uncertain, and habitat conditions are changing. The East Greenland (EG) polar bear subpopulation contains 2275 animals (95% CI = 1...