University of Washington

Comprehensive Analysis of US Health Care Spending on Injuries

BACKGROUND: Traumatic injury affects every age group, payer, and care setting in the United States, yet how injury-related spending distributes across these dimensions has not been comprehensively quantified. OBJECTIVE: To estimate US health care spending on injuries in 2022 by m...

Firearm carrying practices and motivations: A mixed methods study among adults and youth

Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...

Pseudomonas aeruginosa-derived volatile organic compounds modulate AhR signaling to dysregulate airway mucus homeostasis

Pseudomonas aeruginosa frequently infects chronically diseased lungs and exacerbates airway mucus hypersecretion and failure in clearance. P. aeruginosa is metabolically versatile and secretes multiple volatile organic compounds (VOCs), which have been scrutinized as potential bi...

Association between urbanicity–cooking fuel type and self-reported respiratory symptoms as a proxy for acute respiratory infection symptoms among children under two years across ten East African countries

Abstract Introduction Evidence remains limited on how urbanicity modifies the relationship between household cooking fuel type and respiratory symptoms in young children in low- and middle-income countries (LMICs). This study examined the prevalence of cough and dyspnea across te...

Exploring the protective role of school peers in substance use prevention among American Indian adolescents

Social network scholars have long recognized the role that social connections play in the substance use behavior of adolescents as they rely less on their parents/caregivers and more on their school peers. In this article, we explore the role of social networks as they relate to...

Evaluating harvest risk with limited data: A case study on polar bears ( Ursus maritimus ) in East Greenland

Abstract Evaluating the impact of human‐caused removals on wildlife is challenging, especially when population data are limited, future monitoring is uncertain, and habitat conditions are changing. The East Greenland (EG) polar bear subpopulation contains 2275 animals (95% CI = 1...

Investigating Associations Between Signal Intensity of Silent MR Angiography and Hemodynamic Information From 4D Flow MRI in Brain Arteriovenous Malformation

BACKGROUND: Whether signal intensity (SI) on Silent MRA reflects hemodynamics in brain arteriovenous malformations (BAVMs) is unclear. OBJECTIVES: To evaluate the relationship between Silent MRA SI and 4D flow-derived hemodynamic parameters and examine whether Silent MRA-based me...

Arterial Spin‐Labeling MRI at the Cortical‐ CSF Interface: A Novel Biomarker in Alzheimer Disease

BACKGROUND/OBJECTIVE: Arterial spin-labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF-adjacent water transport physiology. We developed an automated pipeline to extract cortical-CSF interface (IF) perfusion for compar...

Weft-Backed Cooling Fabric for Personal Thermal and Moisture Management

Abstract During intense physical activity or exposure to solar radiation in hot and humid environments, heat continuously accumulates at the body surface and induces excessive sweating, thereby increasing the risks of dehydration, heat exhaustion, and even heat stroke, which seve...

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Structural variants (SV), genomic alterations spanning more than 50 base pairs, can significantly impact gene expression and protein function. However, their contribution to Alzheimer’s disease (AD) remains poorly understood. Leveraging a novel SV calling pipeline, we identified...

Wastewater-BasedEpidemiology of Sexually TransmittedPathogens Across Scales

Abstract Wastewater-based epidemiology for sexually transmitted pathogens Chlamydia trachomatis (chlamydia), Neisseria gonorrhoeae (gonorrhea), and Treponema pallidum (syphilis) is sparse compared to viral targets despite their public health significance. We used multiplex, digit...

Optimization Strategies for the Design and Application of Titanium Structures in Aerospace Produced by Electron Beam Powder Bed Fusion

Material optimization of structures is critical in aerospace applications where the overall performance and lifecycle cost is highly sensitive to the vehicle weight. The added complexity enabled by powder bed fusion additive manufacturing technologies provides engineers the abili...

Multi-sensor continuous-flow bioreactor for dynamic and scalable cell culture

Abstract Bioreactors are essential tools in tissue engineering and advanced cell culture because they provide dynamic environments that support cellular growth, organization and tissue maturation. However, most existing systems lack integrated real-time monitoring and feedback co...

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Second HarmonicNonlinear Warburg Admittance AnalysisEliminates Information Loss from Linearization in Traditional EIS:Theory and Experimental Validation

Abstract Low-frequency impedance or admittance experiments of reversible redox couples in well-supported quiescent electrolyte are normally analyzed using a linearized semi-infinite Warburg element with a single lumped parameter. Because each species of a redox couple has a disti...

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD), an autosomal domina...

The Zooplankton International Geospatial dataset: A global repository of spatiotemporal freshwater zooplankton community composition data from lakes and reservoirs to support ecological research

Abstract Zooplankton transfer substantial energy in aquatic food webs and are used as indicators of environmental change. Syntheses of zooplankton community dynamics globally require datasets that span a wide range of environmental gradients; however, these datasets are limited d...

Rural Background, Training Exposure, and Rural Practice Location Among US Physicians

This cross-sectional study assesses the interdependence of rural background and training as factors associated with rural practice among US physicians.

The Impact of Septorhinoplasty on Work Productivity and Activity Impairment: A Multi‐Institutional, Prospective Cohort

OBJECTIVE: To evaluate the effect of septorhinoplasty on work productivity and activity impairment. STUDY DESIGN: Prospective cohort. SETTING: Four tertiary institutions. METHODS: Adults undergoing septorhinoplasty were administered surveys preoperatively and 3 to 8 months postop...